Now showing items 1-7 of 7

    • AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation 

      Herter, Jan M.; Grabie, Nir; Cullere, Xavier; Azcutia, Veronica; Rosetti, Florencia; Bennett, Paul; Herter-Sprie, Grit S.; Elyaman, Wassim; Luscinskas, Francis W.; Lichtman, Andrew H.; Mayadas, Tanya N. (Nature Publishing Group, 2015)
      The mechanisms driving T cell homing to lymph nodes and migration to tissue are well described but little is known about factors that affect T cell egress from tissues. Here, we generate mice with a T cell-specific deletion ...
    • Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions 

      Zahr, Alisar; Alcaide, Pilar; Yang, Jinling; Jones, Alexander; Gregory, Meredith; dela Paz, Nathaniel G.; Patel-Hett, Sunita; Nevers, Tania; Koirala, Adarsha; Luscinskas, Francis W.; Saint-Geniez, Magali; Ksander, Bruce; D'Amore, Patricia A.; Argüeso, Pablo (Nature Publishing Group, 2016)
      Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on ...
    • Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo 

      Azcutia, Verónica; Abu-Taha, May; Romacho, Tania; Vázquez-Bella, Marta; Matesanz, Nuria; Luscinskas, Francis William; Rodríguez-Mañas, Leocadio; Sanz, María Jesús; Sánchez-Ferrer, Carlos F.; Peiró, Concepción (Public Library of Science, 2010)
      Background: Hyperglycemia is acknowledged as an independent risk factor for developing diabetes-associated atherosclerosis. At present, most therapeutic approaches are targeted at a tight glycemic control in diabetic ...
    • Integrin-Mediated Neutrophil Adhesion and Retinal Leukostasis in Diabetes 

      Barouch, FC; Miyamoto, Kazuaki; Allport, Jennifer; Fujita, Kenji; Bursell, Sven-Erik; Aiello, Lloyd Paul; Luscinskas, Francis William; Adamis, Anthony Peter (Association for Research in Vision and Ophthalmology, 2000)
      Purpose. A critical early event in the pathogenesis of diabetic retinopathy is leukocyte adhesion to the diabetic retinal vasculature. The process is mediated, in part, by intercellular adhesion molecule-1 (ICAM-1) and ...
    • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata 

      Swirski, Filip K.; Libby, Peter; Aikawa, Elena; Alcaide, Pilar; Luscinskas, Francis William; Weissleder, Ralph; Pittet, Mikael J. (American Society for Clinical Investigation, 2007)
      Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative ...
    • Migration of Myeloid Cells during Inflammation Is Differentially Regulated by the Cell Surface Receptors Slamf1 and Slamf8 

      Wang, Guoxing; van Driel, Boaz J.; Liao, Gongxian; O’Keeffe, Michael S.; Halibozek, Peter J.; Flipse, Jacky; Yigit, Burcu; Azcutia, Veronica; Luscinskas, Francis W.; Wang, Ninghai; Terhorst, Cox (Public Library of Science, 2015)
      Previous studies have demonstrated that the cell surface receptor Slamf1 (CD150) is requisite for optimal NADPH-oxidase (Nox2) dependent reactive oxygen species (ROS) production by phagocytes in response to Gram- bacteria. ...
    • Statins Suppress Apolipoprotein CIII-Induced Vascular Endothelial Cell Activation and Monocyte Adhesion 

      Zheng, Chunyu; Azcutia, Veronica; Aikawa, Elena; Figueiredo, Jose-Luiz; Croce, Kevin James; Sonoki, Hiroyuki; Sacks, Frank Martin; Luscinskas, Francis William; Aikawa, Masanori (Oxford University Press, 2012)
      Aims: Activation of vascular endothelial cells (ECs) contributes importantly to inflammation and atherogenesis. We previously reported that apolipoprotein CIII (apoCIII), found abundantly on circulating triglyceride-rich ...