Browsing by Author "Gerszten, Robert"

Now showing items 1-19 of 19

    • Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab 

      Sawaya, H.; Sebag, I. A.; Plana, J. C.; Januzzi, James Louis; Ky, B.; Tan, T. C.; Cohen, V.; Banchs, J.; Carver, J. R.; Wiegers, S. E.; Martin, R. P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, E; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and ...

    • Dimethylglycine Deficiency and the Development of Diabetes 

      Magnusson, Martin; Wang, Thomas J.; Clish, Clary; Engström, Gunnar; Nilsson, Peter; Gerszten, Robert E.; Melander, Olle (American Diabetes Association, 2015)
      Experimental studies have suggested possible protective effects of dimethylglycine (DMG) on glucose metabolism. DMG is degraded to glycine through a DMG-dehydrogenase (DMGDH)-catalyzed reaction, and this is the only known ...

    • Distinct Metabolomic Signatures Are Associated with Longevity in Humans 

      Cheng, Susan; Larson, Martin G.; McCabe, Elizabeth L.; Murabito, Joanne M.; Rhee, Eugene P.; Ho, Jennifer E.; Jacques, Paul F.; Ghorbani, Anahita; Magnusson, Martin; Souza, Amanda L.; Deik, Amy A.; Pierce, Kerry A.; Bullock, Kevin; O’Donnell, Christopher J.; Melander, Olle; Clish, Clary B.; Vasan, Ramachandran S.; Gerszten, Robert E.; Wang, Thomas J. (2015)
      Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to ...

    • Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients 

      Sawaya, Heloisa; Sebag, Igal A.; Plana, Juan Carlos; Januzzi, James Louis; Ky, Bonnie; Cohen, Victor; Gosavi, Sucheta; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction ...

    • Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab 

      Ky, Bonnie; Putt, Mary; Sawaya, Heloisa; French, Benjamin; Januzzi, James Louis; Sebag, Igal A.; Plana, Juan Carlos; Cohen, Victor; Banchs, Jose; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2014)
      Objectives: The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. Background: Current methods to identify ...

    • Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development 

      Mayers, Jared R.; Wu, Chen; Clish, Clary B.; Kraft, Peter; Torrence, Margaret E.; Fiske, Brian P.; Yuan, Chen; Bao, Ying; Townsend, Mary K.; Tworoger, Shelley S.; Davidson, Shawn M.; Papagiannakopoulos, Thales; Yang, Annan; Dayton, Talya L.; Ogino, Shuji; Stampfer, Meir J.; Giovannucci, Edward L.; Qian, Zhi Rong; Rubinson, Douglas A.; Ma, Jing; Sesso, Howard D.; Gaziano, John Michael; Cochrane, Barbara B.; Liu, Simin; Wactawski–Wende, Jean; Manson, JoAnn E.; Pollak, Michael N.; Kimmelman, Alec C.; Souza, Amanda; Pierce, Kerry; Wang, Thomas J.; Gerszten, Robert E.; Fuchs, Charles S.; Heiden, Matthew G. Vander; Wolpin, Brian M. (2014)
      Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months1. PDAC has been linked with obesity and glucose intolerance2-4, but whether changes in circulating ...

    • An exome array study of the plasma metabolome 

      Rhee, Eugene P.; Yang, Qiong; Yu, Bing; Liu, Xuan; Cheng, Susan; Deik, Amy; Pierce, Kerry A.; Bullock, Kevin; Ho, Jennifer E.; Levy, Daniel; Florez, Jose C.; Kathiresan, Sek; Larson, Martin G.; Vasan, Ramachandran S.; Clish, Clary B.; Wang, Thomas J.; Boerwinkle, Eric; O'Donnell, Christopher J.; Gerszten, Robert E. (Nature Publishing Group, 2016)
      The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip ...

    • The genetic architecture of NAFLD among inbred strains of mice 

      Hui, Simon T; Parks, Brian W; Org, Elin; Norheim, Frode; Che, Nam; Pan, Calvin; Castellani, Lawrence W; Charugundla, Sarada; Dirks, Darwin L; Psychogios, Nikolaos; Neuhaus, Isaac; Gerszten, Robert E; Kirchgessner, Todd; Gargalovic, Peter S; Lusis, Aldons J (eLife Sciences Publications, Ltd, 2015)
      To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse ...

    • Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis 

      Wagschal, Alexandre; Najafi-Shoushtari, S Hani; Wang, Lifeng; Goedeke, Leigh; Sinha, Sumita; deLemos, Andrew S; Black, Josh C; Ramírez, Cristina M; Li, Yingxia; Tewhey, Ryan; Hatoum, Ida; Shah, Naisha; Lu, Yong; Kristo, Fjoralba; Psychogios, Nikolaos; Vrbanac, Vladimir; Lu, Yi-Chien; Hla, Timothy T; de Cabo, Rafael; Tsang, John S; Schadt, Eric; Sabeti, Pardis Christine; Kathiresan, Sekar; Cohen, David E; Whetstine, Johnathan; Chung, Raymond Taeyong; Fernández-Hernando, Carlos; Kaplan, Lee Michael; Bernards, Andre; Gerszten, Robert Edgardo; Naar, Anders Michael (Springer Nature, 2015)
      Genome-wide association studies (GWASs) have linked genes to various pathological traits. However, the potential contribution of regulatory noncoding RNAs, such as microRNAs (miRNAs), to a genetic predisposition to ...

    • Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy 

      Loffredo, Francesco; Steinhauser, Matthew L.; Jay, Steven M.; Gannon, Joseph; Pancoast, James R.; Yalamanchi, Pratyusha; Sinha, Manisha; Dall’Osso, Claudia; Khong, Danika Mei Po; Shadrach, J; Miller, Christine; Singer, Britta S.; Stewart, Alex; Psychogios, Nikolaos; Gerszten, Robert Edgardo; Hartigan, Adam J.; Kim, Mi-Jeong; Serwold, Thomas Francis; Wagers, Amy Jo; Lee, Richard Theodore (Elsevier BV, 2013)
      The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested ...

    • IKK\(\beta\) Regulates Essential Functions of the Vascular Endothelium Through Kinase-Dependent and -Independent Pathways 

      Ashida, Noboru; SenBanerjee, Sucharita B.; Kodama, Shohta; Foo, Shi Yin; Coggins, Matthew Peter; Spencer, Joel A.; Zamiri, Parisa; Shen, Dongxiao; Li, Ling; Sciuto, Tracey; Dvorak, Ann Marie; Gerszten, Robert Edgardo; Lin, Charles P.; Karin, Michael; Rosenzweig, Anthony (Nature Publishing Group, 2011)
      Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)- \(\kappa\)B ...

    • Interpreting Metabolomic Profiles using Unbiased Pathway Models 

      Hunter, Luke; Pare, Guillaume; Vasan, Ramachandran S.; Lewis, Gregory D; Wang, Thomas Jue-Fuu; Chasman, Daniel Ian; Gerszten, Robert Edgardo; Deo, Rahul Chandrakant; Roth, Frederick Phillip (Public Library of Science, 2010)
      Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...

    • Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab 

      Putt, M.; Hahn, V. S.; Januzzi, James Louis; Sawaya, H.; Sebag, I. A.; Plana, J. C.; Picard, Michael Howard; Carver, J. R.; Halpern, E; Kuter, Irene; Passeri, Jonathan James; Cohen, V.; Banchs, J.; Martin, R. P.; Gerszten, Robert Edgardo; Scherrer-Crosbie, Marielle; Ky, B. (American Association for Clinical Chemistry (AACC), 2015)
      BACKGROUND: Biomarkers may play an important role in identifying patients at risk for cancer therapy cardiotoxicity. Our objectives were to define the patterns of change in biomarkers with cancer therapy and their associations ...

    • Metabolite Profiles During Oral Glucose Challenge 

      Ho, Jennifer E.; Larson, Martin G.; Vasan, Ramachandran S.; Ghorbani, Anahita; Cheng, Susan; Rhee, Eugene P.; Florez, Jose C.; Clish, Clary B.; Gerszten, Robert E.; Wang, Thomas J. (American Diabetes Association, 2013)
      To identify distinct biological pathways of glucose metabolism, we conducted a systematic evaluation of biochemical changes after an oral glucose tolerance test (OGTT) in a community-based population. Metabolic profiling ...

    • Metabolite Profiles Predict Acute Kidney Injury and Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement 

      Elmariah, Sammy; Farrell, Laurie A.; Daher, Maureen; Shi, Xu; Keyes, Michelle J.; Cain, Carolyn H.; Pomerantsev, Eugene; Vlahakes, Gus J.; Inglessis, Ignacio; Passeri, Jonathan J.; Palacios, Igor F.; Fox, Caroline S.; Rhee, Eugene P.; Gerszten, Robert E. (John Wiley and Sons Inc., 2016)
      Background: Acute kidney injury (AKI) occurs commonly after transcatheter aortic valve replacement (TAVR) and is associated with markedly increased postoperative mortality. We previously identified plasma metabolites ...

    • Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes 

      Ho, Jennifer E.; Larson, Martin G.; Ghorbani, Anahita; Cheng, Susan; Chen, Ming-Huei; Keyes, Michelle; Rhee, Eugene P.; Clish, Clary B.; Vasan, Ramachandran S.; Gerszten, Robert E.; Wang, Thomas J. (Public Library of Science, 2016)
      Background: Although obesity and cardiometabolic traits commonly overlap, underlying pathways remain incompletely defined. The association of metabolite profiles across multiple cardiometabolic traits may lend insights ...

    • A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids 

      Cavallaro, Nicole Landa; Garry, Jamie; Shi, Xu; Gerszten, Robert E.; Anderson, Ellen J.; Walford, Geoffrey A. (Co-Action Publishing, 2016)
      Background: Elevated fasting levels of branched chain amino acids (BCAAs: valine, isoleucine, leucine) in venous blood are associated with a variety of metabolic impairments, including increased risk of type 2 diabetes ...

    • Programming human pluripotent stem cells into white and brown adipocytes 

      Ahfeldt, Tim; Schinzel, Robert T.; Lee, Youn-Kyoung; Hendrickson, David Gillis; Kaplan, Adam; Lum, David H.; Camahort, Raymond; Xia, Fang; Shay, Jennifer B.; Rhee, Eugene Park; Clish, Clary B.; Deo, Rahul C.; Shen, Tony; Lau, Frank; Cowley, Alicia; Mowrer, Greg; Al-Siddiqi, Heba; Nahrendorf, Matthias; Musunuru, Kiran; Gerszten, Robert Edgardo; Rinn, John L; Cowan, Chad A. (Nature Publishing Group, 2012)
      The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human ...

    • β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors 

      Roberts, Lee D.; Boström, Pontus; O’Sullivan, John F.; Schinzel, Robert T.; Lewis, Gregory D; Dejam, Andre; Lee, Youn-Kyoung; Palma, Melinda J.; Calhoun, Sondra; Georgiadi, Anastasia; Chen, Ming-Huei; Ramachandran, Vasan S.; Larson, Martin G.; Bouchard, Claude; Rankinen, Tuomo; Souza, Amanda L.; Clish, Clary B.; Wang, Thomas J.; Estall, Jennifer L.; Soukas, Alexander Anastasios; Cowan, Chad A.; Spiegelman, Bruce Michael; Gerszten, Robert Edgardo (Elsevier BV, 2014)
      The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise. Muscle PGC-1α ...