Browsing by Author "Chu, Qian"
Now showing items 1-2 of 2
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I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
Chu, Qian (2014-02-25)Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ... -
Inhibition of Oncogenic Wnt Signaling through Direct Targeting of β-Catenin
Grossmann, Tom N.; Yeh, Johannes Johannes; Bowman, Brian R.; Chu, Qian; Moellering, Raymond E.; Verdine, Gregory L. (Proceedings of the National Academy of Sciences, 2012)Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, ...