Now showing items 1-8 of 8

    • Cyclic Strain Induces Dual-Mode Endothelial-Mesenchymal Transformation of the Cardiac Valve 

      Balachandran, Kartik; Alford, Patrick W.; Wylie-Sears, Jill; Goss, Josue; Grosberg, Anna; Bischoff, Joyce E.; Aikawa, Elena; Levine, Robert A.; Parker, Kevin Kit (Proceedings of the National Academy of Sciences, 2011)
      Endothelial-mesenchymal transformation (EMT) is a critical event for the embryonic morphogenesis of cardiac valves. Inducers of EMT during valvulogenesis include VEGF, TGF-β1, and wnt/β-catenin (where wnt refers to the ...
    • Genetic association analyses highlight biological pathways underlying mitral valve prolapse 

      Dina, Christian; Bouatia-Naji, Nabila; Tucker, Nathan; Delling, Francesca N.; Toomer, Katelynn; Durst, Ronen; Perrocheau, Maelle; Fernandez-Friera, Leticia; Solis, Jorge; Le Tourneau, Thierry; Chen, Ming-Huei; Probst, Vincent; Bosse, Yohan; Pibarot, Philippe; Zelenika, Diana; Lathrop, Mark; Hercberg, Serge; Roussel, Ronan; Benjamin, Emelia J.; Bonnet, Fabrice; Su Hao, LO; Dolmatova, Elena; Simonet, Floriane; Lecointe, Simon; Kyndt, Florence; Redon, Richard; Le Marec, Hervé; Froguel, Philippe; Ellinor, Patrick T.; Vasan, Ramachandran S.; Bruneval, Patrick; Norris, Russell A.; Milan, David J.; Slaugenhaupt, Susan A.; Levine, Robert A.; Schott, Jean-Jacques; Hagege, Albert A.; Jeunemaitre, Xavier (2016)
      Non-syndromic mitral valve prolapse (MVP) is a common degenerative cardiac valvulopathy of unknown aetiology that predisposes to mitral regurgitation, heart failure and sudden death1. Previous family and pathophysiological ...
    • IDH1 and IDH2 Mutation Studies in 1473 Patients with Chronic-, Fibrotic- or Blast-Phase Essential Thrombocythemia, Polycythemia Vera or Myelofibrosis 

      Tefferi, A; Lasho, T L; Abdel-Wahab, O; Guglielmelli, P; Caramazza, D; Pieri, L; Finke, C M; Kilpivaara, O; Mai, M; Gilliland, Dwight; Pardanani, A; Vannucchi, A M; Patel, J.; Wadleigh, Martha; McClure, R. F.; Levine, Robert A. (Nature Publishing Group, 2010)
      In a multi-institutional collaborative project, 1473 patients with myeloproliferative neoplasms (MPN) were screened for isocitrate dehydrogenase 1 (IDH1)/IDH2 mutations: 594 essential thrombocythemia (ET), 421 polycythemia ...
    • Leaflet Area as a Determinant of Tricuspid Regurgitation Severity in Patients With Pulmonary Hypertension 

      Afilalo, J.; Grapsa, J.; Nihoyannopoulos, P.; Beaudoin, J.; Gibbs, J. S. R.; Channick, Richard Neil; Langleben, D.; Rudski, L. G.; Hua, L.; Handschumacher, M. D.; Picard, Michael Howard; Levine, Robert A. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background: Tricuspid regurgitation (TR) is a risk factor for mortality in pulmonary hypertension (PH). TR severity varies among patients with comparable degrees of PH and right ventricular (RV) remodeling. The contribution ...
    • Learning Curve for Quantification of Right Ventricular Size and Systolic Function in Pulmonary Arterial Hypertension: Comparison of Cardiac Magnetic Resonance and Three-Dimensional Echocardiography 

      Afilalo, Jonathan; Grapsa, Julia; Durighel, Giuliana; ORegan, Declan; Dawson, David Michael; Levine, Robert A.; Nihoyannopoulos, Petros (BioMed Central, 2012)
    • Mechanism of Decrease in Mitral Regurgitation After Cardiac Resynchronization Therapy: Optimization of the Force-Balance Relationship 

      Solis, J.; McCarty, D.; Levine, Robert A.; Handschumacher, M. D.; Fernandez-Friera, L.; Chen-Tournoux, A.; Mont, L.; Vidal, Barbara Crystal; Singh, Jagmeet P.; Brugada, J.; Picard, Michael Howard; Sitges, M.; Hung, Judy Weiming (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background: Cardiac resynchronization therapy (CRT) has been shown to reduce functional mitral regurgitation (MR). It has been proposed that the mechanism of MR reduction relates to geometric change or, alternatively, ...
    • Mutations in DCHS1 Cause Mitral Valve Prolapse 

      Durst, Ronen; Sauls, Kimberly; Peal, David S; deVlaming, Annemarieke; Toomer, Katelynn; Leyne, Maire; Salani, Monica; Talkowski, Michael E.; Brand, Harrison; Perrocheau, Maëlle; Simpson, Charles; Jett, Christopher; Stone, Matthew R.; Charles, Florie; Chiang, Colby; Lynch, Stacey N.; Bouatia-Naji, Nabila; Delling, Francesca N.; Freed, Lisa A.; Tribouilloy, Christophe; Le Tourneau, Thierry; LeMarec, Hervé; Fernandez-Friera, Leticia; Solis, Jorge; Trujillano, Daniel; Ossowski, Stephan; Estivill, Xavier; Dina, Christian; Bruneval, Patrick; Chester, Adrian; Schott, Jean-Jacques; Irvine, Kenneth D.; Mao, Yaopan; Wessels, Andy; Motiwala, Tahirali; Puceat, Michel; Tsukasaki, Yoshikazu; Menick, Donald R.; Kasiganesan, Harinath; Nie, Xingju; Broome, Ann-Marie; Williams, Katherine; Johnson, Amanda; Markwald, Roger R.; Jeunemaitre, Xavier; Hagege, Albert; Levine, Robert A.; Milan, David J.; Norris, Russell A.; Slaugenhaupt, Susan A. (2015)
      SUMMARY Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40 individuals1–3. It can manifest as mitral regurgitation and is the leading indication for mitral valve surgery4,5. Despite ...
    • MVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions 

      Duval, Damien; Labbé, Pauline; Bureau, Léa; Le Tourneau, Thierry; Norris, Russell A.; Markwald, Roger R.; Levine, Robert; Schott, Jean-Jacques; Mérot, Jean (2015)
      Although the genetic basis of mitral valve prolapse (MVP) has now been clearly established, the molecular and cellular mechanisms involved in the pathological processes associated to a specific mutation often remain to be ...