Browsing by Author "Cornelissen, Laura"
Now showing items 1-5 of 5
-
Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants
Cornelissen, Laura Louise; Kim, Seong-Eun; Purdon, Patrick Lee; Brown, Emery Neal; Berde, Charles Benjamin (eLife Sciences Organisation, Ltd., 2015)Electroencephalogram (EEG) approaches may provide important information about developmental changes in brain-state dynamics during general anesthesia. We used multi-electrode EEG, analyzed with multitaper spectral methods ... -
Electroencephalography during general anaesthesia differs between term-born and premature-born children
Poorun, Ravi; Hartley, Caroline; Goksan, Sezgi; Worley, Alan; Boyd, Stewart; Cornelissen, Laura Louise; Berde, Charles Benjamin; Rogers, Richard George; Ali, Tariq; Slater, Rebeccah (Elsevier BV, 2016)OBJECTIVES: Premature birth is associated with a wide range of complications in later life, including structural and functional neurological abnormalities and altered pain sensitivity. We investigated whether during ... -
Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study
Cornelissen, Laura; Donado, Carolina; Kim, Joseph; Chiel, Laura; Zurakowski, David; Logan, Deirdre E; Meier, Petra; Sethna, Navil F; Blankenburg, Markus; Zernikow, Boris; Sundel, Robert P; Berde, Charles B (BioMed Central, 2014)Background: Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies ... -
A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia
Lobo, Kimberly; Donado, Carolina; Cornelissen, Laura Louise; Kim, Joseph; Ortiz, Rebeca; Peake, Roy; Kellogg, Mark David; Alexander, Mark Edward; Zurakowski, David; Kurgansky, Katherine E.; Peyton, James Matthew; Bilge, Aykut; Boretsky, Karen Rach; McCann, Mary Ellen; Berde, Charles Benjamin; Cravero, Joseph Peter (Ovid Technologies (Wolters Kluwer Health), 2015)BACKGROUND: Neosaxitoxin (NeoSTX) is a site-1 sodium channel blocker that produces prolonged local anesthesia in animals and humans. Under a Food and Drug Administration-approved phase 1 Investigational New Drug trial, ... -
Transient alterations of cutaneous sensory nerve function by non-invasive cryolipolysis
Garibyan, Lilit; Cornelissen, Laura; Sipprell, William; Pruessner, Joachim; Elmariah, Sarina; Luo, Tuan; Lerner, Ethan A.; Jung, Yookyung; Evans, Conor; Zurakowski, David; Berde, Charles B.; Rox Anderson, R. (2015)Cryolipolysis is a non-invasive, skin cooling treatment for local fat reduction that causes prolonged hypoesthesia over the treated area. We tested the hypothesis that cryolipolysis can attenuate nociception of a range of ...