Browsing by Author "Connole, Michelle"
Now showing items 1-6 of 6
-
B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase
Cariappa, Annaiah; Takematsu, Hiromu; Liu, Haoyuan; Diaz, Sandra; Haider, Khaleda; Kalloo, Geetika; Varki, Nissi; Varki, Ajit; Boboila, Cristian; Connole, Michelle Ann; Shi, Hai Ning; Pillai, Shiv Subramaniam (Rockefeller University Press, 2009)We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that ... -
Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling
Billingsley, James M.; Rajakumar, Premeela A.; Connole, Michelle A.; Salisch, Nadine C.; Adnan, Sama; Kuzmichev, Yury V.; Hong, Henoch S.; Reeves, R. Keith; Kang, Hyung-joo; Li, Wenjun; Li, Qingsheng; Haase, Ashley T.; Johnson, R. Paul (Public Library of Science, 2015)The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As ... -
Hypercytotoxicity and Rapid Loss of NKp44+ Innate Lymphoid Cells during Acute SIV Infection
Li, Haiying; Richert-Spuhler, Laura E.; Evans, Tristan I.; Gillis, Jacqueline; Connole, Michelle; Estes, Jacob D.; Keele, Brandon F.; Klatt, Nichole R.; Reeves, R. Keith (Public Library of Science, 2014)HIV/SIV infections break down the integrity of the gastrointestinal mucosa and lead to chronic immune activation and associated disease progression. Innate lymphoid cells (ILCs), distinguishable by high expression of NKp44 ... -
Maturation of Protective Immunity Induced by SIVΔnef Correlates with Differential Expression of Transcription Factors in SIV-specific CD8+ T Cells
Billingsley, James Michael; Rajakumar, Premeela A.; Salisch, NC; Kuzmichev, YV; Hong, Henoch Sangjoon; Connole, Michelle Ann; Reeves, Roger Keith; Kang, H; Li, W; Johnson, RP (BioMed Central, 2012) -
Paucity of CD4+ Natural Killer T (NKT) Lymphocytes in Sooty Mangabeys is Associated with Lack of NKT Cell Depletion After SIV Infection
Rout, Namita; Else, James G.; Yue, Simon; Connole, Michelle Ann; Exley, Mark Adrian; Kaur, Amitinder (Public Library of Science, 2010)Lack of chronic immune activation in the presence of persistent viremia is a key feature that distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection in natural hosts from pathogenic SIV and HIV infection. ... -
SIVΔnef Vaccination Mobilizes Systemic and Mucosal Natural Killer Cells in Mamu A*01+ Macaques
Reeves, Roger Keith; Evans, Tristan Isaac; Gillis, Jacqueline Marie; Connole, Michelle Ann; Wong, F; Yu, Yi; Johnson, R. Paul (BioMed Central, 2012)