Now showing items 1-6 of 6

    • Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana 

      Shapiro, R.L.; Hughes, M.D.; Ogwu, Anthony; Kitch, Doug William; Lockman, Shahin; Moffat, C.; Makhema, Joseph Moeketsi; Moyo, S; Thior, Ibou; McIntosh, Kenneth; van Widenfelt, E.; Leidner, Jean A.; Powis, Kathleen Marie; Asmelash, A.; Tumbare, E.; Zwerski, S.; Sharma, Upasna; Handelsman, E.; Mburu, K.; Jayeoba, O.; Moko, E.; Souda, Shashidhar Vaman; Lubega, E.; Akhtar, M.; Wester, C William; Tuomola, R.; Snowden, W.; Martinez-Tristani, M.; Mazhani, L.; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2010)
      BACKGROUND: The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are ...
    • Baseline Resistance to Nucleoside Reverse Transcriptase Inhibitors Fails to Predict Virologic Response to Combination Therapy in Children (PACTG 338) 

      Fiscus, Susan A; Kovacs, Andrea; Petch, Leslie A; Hu, Chengcheng; Wiznia, Andrew A; Mofenson, Lynne M; Yogev, Ram; McIntosh, Kenneth; Pelton, Stephen I; Napravnik, Sonia; Stanley, Kenneth Earl; Nachman, Sharon A (BioMed Central, 2007)
      Background: The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children. We evaluated drug resistance mutations at 39 codon sites ...
    • Cotrimoxazole Prophylaxis and Risk of Severe Anemia or Severe Neutropenia in HAART-Exposed, HIV-Uninfected Infants 

      Dryden-Peterson, Scott; Jayeoba, Oluwemimo; Hughes, Michael D.; Jibril, Haruna; McIntosh, Kenneth; Modise, Taolo A.; Asmelash, Aida; Powis, Kathleen M.; Essex, Max; Shapiro, Roger L.; Lockman, Shahin (Public Library of Science, 2013)
      Background: Prophylactic cotrimoxazole is recommended for infants born to HIV-infected mothers. However, cotrimoxazole may increase the risk of severe anemia or neutropenia. Methods: We compared the proportion of HIV-exposed ...
    • Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1–Infected Women in Thailand: Secondary Analysis of a Randomized Trial 

      Briand, Nelly; Lallemant, Marc Jean; Jourdain, Gonzague Joseph Albert; Techapalokul, Somnuek; Tunthanathip, Preecha; Suphanich, Surachet; Chanpoo, Truengta; Traisathit, Patrinee; McIntosh, Kenneth; Coeur, Sophie Le (Public Library of Science, 2007)
      Objectives: To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1−infected ...
    • Modeling of In-Utero and Intra-Partum Transmissions to Evaluate the Efficacy of Interventions for the Prevention of Perinatal HIV 

      Sripan, Patumrat; Le Coeur, Sophie; Amzal, Billy; Ingsrisawang, Lily; Traisathit, Patrinee; Ngo-Giang-Huong, Nicole; McIntosh, Kenneth; Cressey, Tim R.; Sangsawang, Suraphan; Rawangban, Boonsong; Kanjanavikai, Prateep; Tréluyer, Jean-Marc; Jourdain, Gonzague; Lallemant, Marc; Urien, Saïk (Public Library of Science, 2015)
      Background: Antiretroviral treatments decrease HIV mother-to-child transmission through pre/post exposure prophylaxis and reduction of maternal viral load. We modeled in-utero and intra-partum HIV transmissions to investigate ...
    • Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized, Non-Inferiority Trial in Thailand 

      Jourdain, Gonzague; Le Cœur, Sophie; Ngo-Giang-Huong, Nicole; Traisathit, Patrinee; Cressey, Tim R.; Fregonese, Federica; Leurent, Baptiste; Collins, Intira J.; Techapornroong, Malee; Banchongkit, Sukit; Buranabanjasatean, Sudanee; Halue, Guttiga; Nilmanat, Ampaipith; Luekamlung, Nuananong; Klinbuayaem, Virat; Chutanunta, Apichat; Kantipong, Pacharee; Bowonwatanuwong, Chureeratana; Lertkoonalak, Rittha; Leenasirimakul, Prattana; Tansuphasawasdikul, Somboon; Sang-a-gad, Pensiriwan; Pathipvanich, Panita; Thongbuaban, Srisuda; Wittayapraparat, Pakorn; Eiamsirikit, Naree; Buranawanitchakorn, Yuwadee; Yutthakasemsunt, Naruepon; Winiyakul, Narong; Decker, Luc; Barbier, Sylvaine; Koetsawang, Suporn; Sirirungsi, Wasna; McIntosh, Kenneth; Thanprasertsuk, Sombat; Lallemant, Marc (Public Library of Science, 2013)
      Background: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was ...