Now showing items 1-4 of 4

    • Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment 

      Klattenhoff, Carla A.; Scheuermann, Johanna C.; Surface, Lauren E.; Bradley, Robert K.; Fields, Paul A.; Steinhauser, Matthew L.; Ding, Huiming; Butty, Vincent L.; Torrey, Lillian; Haas, Simon; Abo, Ryan; Tabebordbar, Mohammadsharif; Lee, Richard Theodore; Burge, Christopher B.; Boyer, Laurie A. (Elsevier BV, 2013)
      Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. ...
    • An Engineered Bivalent Neuregulin Protects Against Doxorubicin-Induced Cardiotoxicity With Reduced Proneoplastic Potential 

      Jay, S. M.; Murthy, A. C.; Hawkins, Jessica Faye; Wortzel, Joshua Ross; Steinhauser, Matthew L.; Alvarez, L. M.; Gannon, J.; MacRae, Calum Archibald; Griffith, L. G.; Lee, Richard Theodore (Ovid Technologies (Wolters Kluwer Health), 2013)
      Background—Doxorubicin (DOXO) is an effective anthracycline chemotherapeutic, but its use is limited by cumulative dose-dependent cardiotoxicity. Neuregulin-1β is an ErbB receptor family ligand that is effective against ...
    • Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy 

      Loffredo, Francesco; Steinhauser, Matthew L.; Jay, Steven M.; Gannon, Joseph; Pancoast, James R.; Yalamanchi, Pratyusha; Sinha, Manisha; Dall’Osso, Claudia; Khong, Danika Mei Po; Shadrach, J; Miller, Christine; Singer, Britta S.; Stewart, Alex; Psychogios, Nikolaos; Gerszten, Robert Edgardo; Hartigan, Adam J.; Kim, Mi-Jeong; Serwold, Thomas Francis; Wagers, Amy Jo; Lee, Richard Theodore (Elsevier BV, 2013)
      The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested ...
    • Regeneration of the heart 

      Steinhauser, Matthew L.; Lee, Richard Theodore (WILEY-VCH Verlag, 2011)
      The death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the dominant causes of death worldwide. Other than transplantation, there are no therapies that directly ...