Now showing items 1-6 of 6

    • Aromatase Inhibitors As Adjuvant Therapy for Postmenopausal Women: A Therapeutic Advance But Many Unresolved Questions 

      Ligibel, Jennifer A.; Winer, Eric Paul (BioMed Central, 2005)
      Adjuvant hormonal therapy for postmenopausal women with early stage breast cancer has become far more complex over the past several years. This commentary reviews the current status of the five major trials evaluating the ...
    • Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases 

      Ni, Jing; Ramkissoon, Shakti H.; Xie, Shaozhen; Goel, Shom; Stover, Daniel G.; Guo, Hanbing; Luu, Victor; Marco, Eugenio; Ramkissoon, Lori A.; Kang, Yun Jee; Hayashi, Marika; Nguyen, Quang-De; Ligon, Azra H.; Du, Rose; Claus, Elizabeth B.; Alexander, Brian M.; Yuan, Guo-Cheng; Wang, Zhigang C.; Iglehart, J. Dirk; Krop, Ian E.; Roberts, Thomas M.; Winer, Eric P.; Lin, Nancy U.; Ligon, Keith L.; Zhao, Jean J. (2016)
      Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases ...
    • International Guidelines for Management of Metastatic Breast Cancer: Can Metastatic Breast Cancer Be Cured? 

      Pagani, Olivia; Senkus, Elżbieta; Wood, William; Colleoni, Marco; Cufer, Tanja; Kyriakides, Stella; Costa, Alberto; Winer, Eric Paul; Cardoso, Fatima (Oxford University Press, 2010)
      A distinctive subset of metastatic breast cancer (MBC) is oligometastatic disease, which is characterized by single or few detectable metastatic lesions. The existing treatment guidelines for patients with localized MBC ...
    • Response and resistance to BET bromodomain inhibitors in triple negative breast cancer 

      Shu, Shaokun; Lin, Charles Y.; He, Housheng Hansen; Witwicki, Robert M.; Tabassum, Doris P.; Roberts, Justin M.; Janiszewska, Michalina; Huh, Sung Jin; Liang, Yi; Ryan, Jeremy; Doherty, Ernest; Mohammed, Hisham; Guo, Hao; Stover, Daniel G.; Ekram, Muhammad B.; Brown, Jonathan; D'Santos, Clive; Krop, Ian E.; Dillon, Deborah; McKeown, Michael; Ott, Christopher; Qi, Jun; Ni, Min; Rao, Prakash K.; Duarte, Melissa; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Anders, Lars; Young, Richard A.; Winer, Eric; Letai, Antony; Barry, William T.; Carroll, Jason S.; Long, Henry; Brown, Myles; Liu, X. Shirley; Meyer, Clifford A.; Bradner, James E.; Polyak, Kornelia (2015)
      Triple negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy1-3. BET bromodomain inhibitors, which have shown efficacy in several models of cancer4-6, ...
    • Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? 

      Westover, Kenneth Dale; Westover, Michael Brandon; Winer, Eric Paul; Richardson, Andrea Lynn; Iglehart, James Dirk; Punglia, Rinaa S. (SAGE-Hindawi Access to Research, 2011)
      A negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on ...
    • Survival Implications Associated with Variation in Mastectomy Rates for Early-Staged Breast Cancer 

      Brooks, John M.; Chrischilles, Elizabeth A.; Landrum, Mary Beth Elizabeth; Wright, Kara B.; Fang, Gang; Winer, Eric Paul; Keating, Nancy Lynn (Hindawi Publishing, 2012)
      Despite a 20-year-old guideline from the National Institutes of Health (NIH) Consensus Development Conference recommending breast conserving surgery with radiation (BCSR) over mastectomy for woman with early-stage breast ...