Now showing items 1-15 of 15

    • Ablation of AMP-Activated Protein Kinase \(\alpha\)2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice 

      Fujii, Nobuharu; Ho, Richard C.; Manabe, Yasuko; Jessen, Niels; Toyoda, Taro; Holland, William; Summers, Scott A.; Hirshman, Michael F.; Goodyear, Laurie Joy (American Diabetes Association, 2008)
      Objective: We determined whether muscle AMP-activated protein kinase (AMPK) has a role in the development of insulin resistance. Research Design and Methods: Muscle-specific transgenic mice expressing an inactive form of ...
    • Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance 

      Liew, Chong Wee; Boucher, Jeremie; Cheong, Jit Kong; Vernochet, Cecile; Koh, Ho-Jin; Mallol, Cristina; Townsend, Kristy; Langin, Dominique; Kawamori, Dan; Hu, Jiang; Tseng, Yu-Hua; Hellerstein, Marc K; Farmer, Stephen R; Goodyear, Laurie; Doria, Alessandro; Blüher, Matthias; Hsu, Stephen I-Hong; Kulkarni, Rohit N (2012)
      SUMMARY Obesity develops due to altered energy homeostasis favoring fat storage. Here we describe a novel transcription co-regulator for adiposity and energy metabolism, TRIP-Br2 (also called SERTAD2). TRIP-Br2 null mice ...
    • Characterization of an Acute Muscle Contraction Model Using Cultured C2C12 Myotubes 

      Manabe, Yasuko; Miyatake, Shouta; Takagi, Mayumi; Nakamura, Mio; Okeda, Ai; Nakano, Taemi; Hirshman, Michael F.; Goodyear, Laurie Joy; Fujii, Nobuharu L. (Public Library of Science, 2012)
      A cultured C2C12 myotube contraction system was examined for application as a model for acute contraction-induced phenotypes of skeletal muscle. C2C12 myotubes seeded into 4-well rectangular plates were placed in a contraction ...
    • Clonal analyses and gene profiling identify genetic biomarkers of human brown and white preadipocyte thermogenic potential 

      Xue, Ruidan; Lynes, Matthew D.; Dreyfuss, Jonathan M.; Shamsi, Farnaz; Schulz, Tim J.; Zhang, Hongbin; Huang, Tian Lian; Townsend, Kristy L.; Li, Yiming; Takahashi, Hirokazu; Weiner, Lauren S.; White, Andrew P.; Lynes, Maureen S.; Rubin, Lee L.; Goodyear, Laurie J.; Cypess, Aaron M.; Tseng, Yu-Hua (2015)
      Targeting brown adipose tissue (BAT) content or activity has therapeutic potential for treating obesity and the metabolic syndrome by increasing energy expenditure. Both inter- and intra-individual differences contribute ...
    • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 

      Lynes, Matthew David; Leiria, Luiz; Lundh, Morten; Bartelt, Alexander; Shamsi, Farnaz; Huang, Tianwen; Takahashi, Hirokazu; Hirshman, Michael F; Schlein, Christian; Lee, Alexandra; Baer, Lisa A; May, Francis J; Gao, Fei; Narain, Niven R; Chen, Emily Y; Kiebish, Michael A; Cypess, Aaron; Blüher, Matthias; Goodyear, Laurie Joy; Hotamisligil, Gokhan S.; Stanford, Kristin I; Tseng, Yu-Hua (Springer Nature, 2017)
      Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and ...
    • Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo 

      Lauritzen, Hans P.M.M.; Brandauer, Josef; Schjerling, Peter; Koh, Ho-Jin; Treebak, Jonas T.; Hirshman, Michael F.; Galbo, Henrik; Goodyear, Laurie J. (American Diabetes Association, 2013)
      Recent studies suggest that interleukin 6 (IL-6) is released from contracting skeletal muscles; however, the cellular origin, secretion kinetics, and signaling mechanisms regulating IL-6 secretion are unknown. To address ...
    • Contraction stimulates muscle glucose uptake independent of atypical PKC 

      Yu, Haiyan; Fujii, Nobuharu L; Toyoda, Taro; An, Ding; Farese, Robert V; Leitges, Michael; Hirshman, Michael F; Mul, Joram D; Goodyear, Laurie J (John Wiley & Sons, Ltd, 2015)
      Exercise increases skeletal muscle glucose uptake, but the underlying mechanisms are only partially understood. The atypical protein kinase C (PKC) isoforms λ and ζ (PKC-λ/ζ) have been shown to be necessary for insulin-, ...
    • Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4 

      Pehmøller, Christian; Brandt, Nina; Birk, Jesper B.; Høeg, Louise D.; Sjøberg, Kim A.; Goodyear, Laurie J.; Kiens, Bente; Richter, Erik A.; Wojtaszewski, Jørgen F.P. (American Diabetes Association, 2012)
      Excess lipid availability causes insulin resistance. We examined the effect of acute exercise on lipid-induced insulin resistance and TBC1 domain family member 1/4 (TBCD1/4)-related signaling in skeletal muscle. In eight ...
    • Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance 

      Schulz, Tim J.; Graja, Antonia; Huang, Tian Lian; Xue, Ruidan; An, Ding; Poehle-Kronawitter, Sophie; Lynes, Matthew D.; Tolkachov, Alexander; O’Sullivan, Lindsay E.; Hirshman, Michael F.; Schupp, Michael; Goodyear, Laurie J.; Mishina, Yuji; Tseng, Yu-Hua (Springer Berlin Heidelberg, 2016)
      Aims/hypothesis Adipose tissue dysfunction is a prime risk factor for the development of metabolic disease. Bone morphogenetic proteins (BMPs) have previously been implicated in adipocyte formation. Here, we investigate ...
    • Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation☆ 

      Obici, Silvana; Magrisso, I. Jack; Ghazarian, Armen S.; Shirazian, Alireza; Miller, Jonas R.; Loyd, Christine M.; Begg, Denovan P.; Krawczewski Carhuatanta, Kimberly A.; Haas, Michael K.; Davis, Jon F.; Woods, Stephen C.; Sandoval, Darleen A.; Seeley, Randy J.; Goodyear, Laurie J.; Pothos, Emmanuel N.; Mul, Joram D. (Elsevier, 2015)
      Objective: Melanocortin-4 receptors (MC4Rs) are highly expressed by dopamine-secreting neurons of the mesolimbic tract, but their functional role has not been fully resolved. Voluntary wheel running (VWR) induces adaptations ...
    • Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle 

      Sinha, M; Jang, Y. C.; Oh, Juhyun; Khong, Danika Mei Po; Wu, Elizabeth Y; Manohar, Rohan; Miller, Christine; Regalado, Samuel G.; Loffredo, F; Pancoast, James R.; Hirshman, Michael F; Lebowitz, Jessica; Shadrach, Jennifer; Cerletti, Massimiliano; Kim, Mi Jeong; Serwold, Thomas Francis; Goodyear, Laurie Joy; Rosner, Bernard Alfred; Lee, Richard Theodore; Wagers, Amy Jo (American Association for the Advancement of Science (AAAS), 2014)
      Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral “rejuvenating” factors that can restore regenerative ...
    • TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle 

      An, Ding Jeff; Toyoda, Taro; Taylor, Eric B.; Yu, Haiyan; Fujii, Nobuharu; Hirshman, Michael F.; Goodyear, Laurie Joy (American Diabetes Association, 2010)
      OBJECTIVE: TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the ...
    • Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism 

      Lee, Kevin Y.; Singh, Manvendra K.; Ussar, Siegfried; Wetzel, Petra; Hirshman, Michael F.; Goodyear, Laurie J.; Kispert, Andreas; Kahn, C. Ronald (Nature Pub. Group, 2015)
      Skeletal muscle is composed of both slow-twitch oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function and eventually whole-body physiology. Here we show that the ...
    • Tribbles 3 Mediates Endoplasmic Reticulum Stress-Induced Insulin Resistance in Skeletal Muscle 

      Koh, Ho-Jin; Toyoda, Taro; Didesch, Michelle M.; Lee, Min-Young; Sleeman, Mark W.; Kulkarni, Rohit N.; Musi, Nicolas; Hirshman, Michael F.; Goodyear, Laurie J. (2013)
      Endoplasmic Reticulum (ER) stress has been linked to insulin resistance in multiple tissues but the role of ER stress in skeletal muscle has not been explored. ER stress has also been reported to increase tribbles 3 (TRB3) ...
    • Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice 

      Mul, Joram D.; Zheng, Jia; Goodyear, Laurie J. (Society for Neuroscience, 2016)
      The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent model is the 5 d repeated forced swim stress (5d-RFSS) ...