Browsing by Author "Tsokos, George"

Now showing items 1-20 of 20

    • Childhood Resistance to Influenza Mortality: Analysis in a Mouse Model 

      Suber, Freeman (2016-08-29)
      During the 1918 influenza pandemic, children experienced significantly lower mortality compared to adults, with the onset of puberty marking a transition to greater disease susceptibility. To explore the mechanisms that ...

    • Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum 

      Spadafora, Carmenza; Awandare, Gordon A.; Kopydlowski, Karen M.; Czege, Jozsef; Moch, J. Kathleen; Finberg, Robert W.; Tsokos, George C.; Stoute, José A. (Public Library of Science, 2010)
      Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are ...

    • Cytokines in Systemic Lupus Erythematosus 

      Poole, Brian D.; Niewold, Timothy B.; Tsokos, George C.; Via, Charles S. (Hindawi Publishing Corporation, 2010)

    • Cytokines in Systemic Lupus Erythematosus 2011 

      Poole, Brian D.; Niewold, Timothy B.; Tsokos, George C. (Hindawi Publishing Corporation, 2012)

    • Decay Accelerating Factor (CD55) Protects Neuronal Cells from Chemical Hypoxia-induced Injury 

      Li, Yansong; Dalle Lucca, Shawn L; Simovic, Milomir; Dalle Lucca, Jurandir J; Tsokos, George C.; Wang, Ying (BioMed Central, 2010)
      Background: Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent ...

    • ICER is requisite for Th17 differentiation 

      Yoshida, Nobuya; Comte, Denis; Mizui, Masayuki; Otomo, Kotaro; Rosetti, Florencia; Mayadas, Tanya N.; Crispín, José C.; Bradley, Sean J.; Koga, Tomohiro; Kono, Michihito; Karampetsou, Maria P.; Kyttaris, Vasileios C.; Tenbrock, Klaus; Tsokos, George C. (Nature Publishing Group, 2016)
      Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the ...

    • Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C 

      del Rio, Roxana; McAllister, Ryan D.; Meeker, Nathan D.; Wall, Emma H.; Bond, Jeffrey P.; Kyttaris, Vasileios; Tsokos, George C.; Tung, Kenneth S. K.; Teuscher, Cory (Public Library of Science, 2012)
      Experimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by immunization with autologous testicular homogenate and appropriate ...

    • IL-17 in Systemic Lupus Erythematosus 

      Crispín, José C.; Tsokos, George C. (Hindawi Publishing Corporation, 2010)
      IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, ...

    • The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity 

      Lieberman, Linda Adelle; Tsokos, George C. (Hindawi Publishing Corporation, 2010)
      IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. ...

    • Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus 

      Wang, Jianxun; Mizui, Masayuki; Zeng, Li-Fan; Bronson, Roderick Terry; Finnell, Michele; Terhorst, Cox; Kyttaris, Vasileios; Tsokos, George C.; Zhang, Zhong-Yin; Kontaridis, Maria Irene (American Society for Clinical Investigation, 2016)
      Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder ...

    • Lupus-Prone Mice Fail to Raise Antigen-Specific T Cell Responses to Intracellular Infection 

      Lieberman, Linda A.; Tsokos, George C. (Public Library of Science, 2014)
      Systemic lupus erythematosus (SLE) is characterized by multiple cellular abnormalities culminating in the production of autoantibodies and immune complexes, resulting in tissue inflammation and organ damage. Besides active ...

    • Platelet-Associated CD40/CD154 Mediates Remote Tissue Damage after Mesenteric Ischemia/Reperfusion Injury 

      Lapchak, Peter H.; Ioannou, Antonis; Kannan, Lakshmi; Rani, Poonam; Dalle Lucca, Jurandir J.; Tsokos, George C. (Public Library of Science, 2012)
      Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors in the process of tissue damage after ischemia ...

    • Protein phosphatase 2A is requisite for the function of regulatory T cells 

      Apostolidis, Sokratis A.; Rodríguez-Rodríguez, Noé; Suárez-Fueyo, Abel; Dioufa, Nikolina; Ozcan, Esra; Crispín, José C.; Tsokos, Maria G.; Tsokos, George C. (2015)
      Immune homeostasis depends on the proper function of regulatory T (Treg) cells. Compromised Treg cell suppressive activity leads to autoimmune disease, graft rejection and promotes anti-tumor immunity. Here we report the ...

    • The Role of Platelet Factor 4 in Local and Remote Tissue Damage in a Mouse Model of Mesenteric Ischemia/Reperfusion Injury 

      Lapchak, Peter H.; Ioannou, Antonis; Rani, Poonam; Lieberman, Linda Adelle; Yoshiya, Kazuhisa; Kannan, Lakshmi; Lucca, Jurandir J. Dalle; Kowalska, M. Anna; Tsokos, George C. (Public Library of Science, 2012)
      The robust inflammatory response that occurs during ischemia reperfusion (IR) injury recruits factors from both the innate and adaptive immune systems. However the contribution of platelets and their products such as ...

    • Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells 

      Moulton, Vaishali R.; Gillooly, Andrew R.; Perl, Marcel A.; Markopoulou, Anastasia; Tsokos, George C. (Public Library of Science, 2015)
      T lymphocytes from many patients with systemic lupus erythematosus (SLE) express decreased levels of the T cell receptor (TCR)-associated CD3 zeta (ζ) signaling chain, a feature directly linked to their abnormal phenotype ...

    • Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling 

      Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C. (Public Library of Science, 2013)
      Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk ...

    • Spleen Tyrosine Kinase Inhibition in the Treatment of Autoimmune, Allergic and Autoinflammatory Diseases 

      Pamuk, Omer Nuri; Tsokos, George C. (BioMed Central, 2010)
      Spleen tyrosine kinase (Syk) is involved in the development of the adaptive immune system and has been recognized as being important in the function of additional cell types, including platelets, phagocytes, fibroblasts, ...

    • T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus 

      Bradley, Sean J.; Suarez-Fueyo, Abel; Moss, David R.; Kyttaris, Vasileios C.; Tsokos, George C. (Public Library of Science, 2015)
      Background: T cells regulate the adaptive immune response and have altered function in autoimmunity. Systemic Lupus Erythematosus (SLE) has great diversity of presentation and treatment response. Peripheral blood component ...

    • Targeting Syk in Autoimmune Rheumatic Diseases 

      Deng, Guo-Min; Kyttaris, Vasileios C.; Tsokos, George C. (Frontiers Media S.A., 2016)
      Spleen tyrosine kinase (Syk) is a member of the Src family of non-receptor tyrosine kinases, which associates directly with surface receptors, including B-cell receptor and Fcγ receptor, and is involved in a variety of ...

    • Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice 

      Kyttaris, Vasileios C.; Kampagianni, Ourania; Tsokos, George C. (Hindawi Publishing Corporation, 2013)
      Interleukin 23 receptor expressing IL-17 producing T cells have been shown to be important in the development of murine lupus. The usefulness of IL-23 inhibition in ameliorating lupus nephritis is unknown. We hypothesized ...