Now showing items 1-2 of 2

    • Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter 

      Wang, Jing; Sun, Chongxiu; Gerdes, Norbert; Liu, Conglin; Liao, Mengyang; Liu, Jianping; Shi, Michael A; He, Aina; Zhou, Yi; Sukhova, Galina K.; Chen, Huimei; Cheng, Xian; Kuzuya, Masafumi; Murohara, Toyoaki; Zhang, Jie; Cheng, Xiang; Jiang, Mengmeng; Shull, Gary E; Rogers, Shaunessy; Yang, Chao-Ling; Ke, Qiang; Jelen, Sabina; Bindels, René; Ellison, David H; Jarolim, Petr; Libby, Peter; Shi, Guo-Ping (Nature Publishing Group, 2015)
      Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms1, 2. Interruption of IL18 action reduces atherosclerosis in mice3, 4. Here, we show that absence of the IL18 receptor (IL18r) does not ...
    • RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis 

      Lauriol, J; Keith, K.; Jaffre, Fabrice; Couvillon, A.; Saci, A.; Goonasekera, S. A.; McCarthy, Jason; Kessinger, Chase; Wang, J; Ke, Q; Kang, Peter Myung-Hoon; Molkentin, J. D.; Carpenter, C.; Kontaridis, Maria Irene (American Association for the Advancement of Science (AAAS), 2014)
      The Ras-related guanosine triphosphatase RhoA mediates pathological cardiac hypertrophy, but also promotes cell survival and is cardioprotective after ischemia/reperfusion injury. To understand how RhoA mediates these ...