Browsing by Author "Regan, Meredith"

Now showing items 1-5 of 5

    • The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer 

      Pomerantz, Mark; Ahmadiyeh, Nasim; Jia, Li; Herman, Paula; Verzi, Michael; Doddapaneni, Harshavardhan; Beckwith, Christine A.; Chan, Jennifer A.; Hills, Adam; Davis, Matt; Yao, Keluo; Kehoe, Sarah M.; Lenz, Heinz-Josef; Haiman, Christopher A.; Yan, Chunli; Henderson, Brian E.; Frenkel, Baruch; Barretina, Jordi; Bass, Adam; Tabernero, Josep; Baselga, Jose; Regan, Meredith; Manak, J. Robert; Shivdasani, Ramesh; Coetzee, Gerhard A.; Freedman, Matthew (Springer Science and Business Media LLC, 2009-06-28)
      An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with ...

    • Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis 

      Chanock, Stephen J.; Schafer, Eric J.; Tabernero, Josep; Baselga, José; Oh, William K.; Pomerantz, Mark M; Shrestha, Yashaswi; Flavin, Richard John; Regan, Meredith Margaret; Penney, Kathryn Lee; Mucci, Lorelei Ann; Stampfer, Meir; Hunter, David J.; Chan, Jennifer Ang; Richardson, Andrea Lynn; Loda, Massimo; Kantoff, Philip Wayne; Hahn, William C.; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target ...

    • Cell Kinetic Studies Fail to Identify Sequentially Proliferating Progenitors as the Major Source of Epithelial Renewal in the Adult Murine Prostate 

      Pignon, Jean-Christophe; Grisanzio, Chiara; Carvo, Ingrid; Werner, Lillian; Regan, Meredith; Wilson, E. Lynette; Signoretti, Sabina (Public Library of Science, 2015)
      There is evidence that stem cells and their progeny play a role in the development of the prostate. Although stem cells are also considered to give rise to differentiated progeny in the adult prostate epithelium ex vivo, ...

    • Digital Quantification of Gene Expression in Sequential Breast Cancer Biopsies Reveals Activation of an Immune Response 

      Jeselsohn, Rinath M.; Werner, Lillian; Regan, Meredith M.; Fatima, Aquila; Gilmore, Lauren; Collins, Laura C.; Beck, Andrew H.; Bailey, Shannon T.; He, Housheng Hansen; Buchwalter, Gilles; Brown, Myles; Iglehart, J. Dirk; Richardson, Andrea; Come, Steven E. (Public Library of Science, 2013)
      Advancements in molecular biology have unveiled multiple breast cancer promoting pathways and potential therapeutic targets. Large randomized clinical trials remain the ultimate means of validating therapeutic efficacy, ...

    • Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX 

      Coates, Alan S; Millar, Ewan KA; O'Toole, Sandra A; Molloy, Timothy J; Viale, Giuseppe; Goldhirsch, Aron; Regan, Meredith M; Gelber, Richard D; Sun, Zhuoxin; Castiglione-Gertsch, Monica; Gusterson, Barry; Musgrove, Elizabeth A; Sutherland, Robert L (BioMed Central, 2012)
      Introduction: The prognostic significance of p53 protein expression in early breast cancer remains uncertain, with some but not all studies finding an association with poorer outcomes. Estrogen receptor (ER) expression is ...