Now showing items 1-20 of 117

    • Acinar Cystadenoma of the Pancreas 

      Khor, Tze S.; Badizadegan, Kamran; Ferrone, Cristina Rosa; Fernandez-Del Castillo, Carlos F.; Desai, Gaurav S.; Saenz, Adam; Le, Long Phi; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      Pancreatic acinar cystadenomas (ACAs) are rare cystic lesions showing acinar differentiation with benign outcome. Although debated, ACAs are favored to be neoplastic and potentially the benign counterpart of acinar ...
    • Adenomatous and Foveolar Gastric Dysplasia: Distinct Patterns of Mucin Expression and Background Intestinal Metaplasia 

      Park, Do Youn; Srivastava, Amitabh; Kim, Gwang Ha; Mino-Kenudson, Mari; Deshpande, Vikram; Zukerberg, Lawrence R.; Song, Geum Am; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous (or intestinal) and foveolar (or gastric) types. Although limited genetic differences have been demonstrated between these subtypes, ...
    • Alpha-CTLA-4 mAb-associated Panenteritis: A Histologic and Immunohistochemical Analysis 

      Oble, Darryl A.; Mino-Kenudson, Mari; Goldsmith, Jeffrey David; Hodi, Frank Stephen; Seliem, Rania M.; Dranoff, Glenn; Mihm, Martin Charles; Hasserjian, Robert Paul; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. ...
    • Are ulcers a marker for invasive carcinoma in barrett's esophagus? data from a diagnostic variability study with clinical follow-up 

      Montgomery, Elizabeth; Bronner, Mary P.; Greenson, Joel K.; Haber, Marian M.; Hart, John; Lamps, Laura W.; Lauwers, Gregory Y.; Lazenby, Audrey J.; Lewin, David N.; Robert, Marie-Claude; Washington, Kay; Goldblum, John R. (Springer Nature, 2002)
      OBJECTIVE: We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers. METHODS: A group of pathologist participants were asked to contribute ...
    • Autoimmune pancreatitis-related cholecystitis: a morphologically and immunologically distinctive form of lymphoplasmacytic sclerosing cholecystitis 

      Wang, Wei-Lia; Farris, Alton B; Lauwers, Gregory Y.; Deshpande, Vikram (Wiley-Blackwell, 2009)
      Aims: Gallbladder involvement in autoimmune pancreatitis (AIP) is reported to be histologically similar to that seen in primary sclerosing cholangitis (PSC) and biliary obstruction secondary to pancreatic ductal adenocarcinoma ...
    • Autoimmune pancreatitis-related diabetes: quantitative analysis of endocrine islet cells and inflammatory infiltrate 

      Farris, Alton B.; Lauwers, Gregory Y.; Deshpande, Vikram (Springer Nature, 2010)
      In autoimmune pancreatitis (AIP), mechanism(s) of paradoxical glycemic control improvement (GCI) often occurring after pancreatic resection and steroid therapy are not fully elucidated. Using image quantitation, AIP cases ...
    • Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria 

      Zen, Yoh; Adsay, N Volkan; Bardadin, Krystof; Colombari, Romano; Ferrell, Linda; Haga, Hironori; Hong, Seung-Mo; Hytiroglou, Prodromos; Klöppel, Günter; Lauwers, Gregory Y.; van Leeuwen, Dirk J; Notohara, Kenji; Oshima, Kiyoko; Quaglia, Alberto; Sasaki, Motoko; Sessa, Fausto; Suriawinata, Arief; Tsui, Wilson; Atomi, Yutaka; Nakanuma, Yasuni (Springer Nature, 2007)
      Cholangiocarcinoma of the intrahepatic and extrahepatic bile ducts develops through a multistep histopathologic sequence. Premalignant or non-invasive neoplastic lesions of bile ducts have been historically called biliary ...
    • Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded 

      Khor, Tze S.; Fujita, Hiroshi; Nagata, Koji; Shimizu, Michio; Lauwers, Gregory Y. (Springer Nature, 2012)
      The interpretation of colonic biopsies related to inflammatory conditions can be challenging because the colorectal mucosa has a limited repertoire of morphologic responses to various injurious agents. Only few processes ...
    • Buried Barrett's Epithelium Following Photodynamic Therapy Shows Reduced Crypt Proliferation and Absence of DNA Content Abnormalities 

      Hornick, Jason L.; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Liu, Weitian; Goyal, Raj K.; Odze, Robert D. (Springer Nature, 2008)
      OBJECTIVES: Photodynamic therapy (PDT) is increasingly used for the treatment of patients with Barrett's esophagus (BE) with dysplasia or early carcinoma. Post-PDT, some patients show residual BE either exposed to the ...
    • CDX2 Expression in the Intestinal-Type Gastric Epithelial Neoplasia: Frequency and Significance. 

      Park, Do Youn; Srivastava, Amitabh; Kim, Gwang Ha; Mino-Kenudson, Mari; Deshpande, Vikram; Zukerberg, Lawrence R.; Song, Geum Am; Lauwers, Gregory Y. (Nature Publishing Group, 2010)
      CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells. In gastric adenocarcinoma, CDX2 expression is known to be associated with limited ...
    • Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation 

      Senger, Stefania; Sapone, Anna; Fiorentino, Maria Rosaria; Mazzarella, Giuseppe; Lauwers, Gregory Y.; Fasano, Alessio (Public Library of Science, 2015)
      Background: In celiac disease (CD), intestinal epithelium damage occurs secondary to an immune insult and is characterized by blunting of the villi and crypt hyperplasia. Similarities between Hedgehog (Hh)/BMP4 downregulation, ...
    • Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study 

      Lisovsky, Mikhail; Dresser, Karen; Baker, Stephen E.; Fisher, Andrew; Woda, Bruce; Banner, Barbara; Lauwers, Gregory Y. (Springer Nature, 2009)
      The diagnosis of gastric epithelial dysplasia, a precursor lesion of gastric adenocarcinoma, is hindered by interobserver variability and by its resemblance to regenerative changes. Loss of cell polarity, a histological ...
    • Chronic Sclerosing Sialadenitis (Küttner Tumor) Is an IgG4-associated Disease 

      Geyer, Julia Turbiner; Ferry, Judith Ann; Harris, Nancy Lee; Stone, John H; Zukerberg, Lawrence R.; Lauwers, Gregory Y.; Pilch, Ben Z.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2010)
      BACKGROUND: Chronic sclerosing sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior Asian study proposed that chronic sclerosing sialadenitis is a ...
    • Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features 

      Soucy, Genevieve; Wang, Helen; Farraye, Francis A; Schmidt, Jason F; Farris, Alton B; Lauwers, Gregory Y.; Cerda, Sandra R; Dendrinos, Kleanthis G; Odze, Robert D. (Springer Nature, 2011)
      Little is known regarding the clinical and, in particular, pathological manifestations of patients with isolated colonic Crohn's disease. The purpose of this study was to evaluate the clinical and pathological features of ...
    • The Clinical Significance of Incidental Chronic Colitis: A Study of 17 Cases 

      Deshpande, Vikram; Hsu, MayLee; Kumarasinghe, M. Priyanthi; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Introduction: A histologic diagnosis of chronic colitis raises a relatively limited differential diagnosis that includes inflammatory bowel disease, long-standing infections, and chronic ischemia. In routine clinical ...
    • Clinicopathologic and Molecular Profiles of Microsatellite Unstable Barrett Esophagus-associated Adenocarcinoma 

      Farris, Alton B.; Demicco, Elizabeth G.; Le, Long Phi; Finberg, Karin E.; Miller, Julie; Mandal, Rajni; Fukuoka, Junya; Cohen, Cynthia; Gaissert, Henning Arthur; Zukerberg, Lawrence R.; Lauwers, Gregory Y.; Iafrate, Anthony John; Mino-Kenudson, Mari (Ovid Technologies (Wolters Kluwer Health), 2011)
      Microsatellite instability (MSI) has been reported in various tumors, with colon cancer as the prototype. However, little is known about MSI in Barrett esophagus (BE)-associated adenocarcinoma. Thus, the aim of this study ...
    • Co-Registered Spectrally Encoded Confocal Microscopy and Optical Frequency Domain Imaging System 

      Kang, D.K.; Suter, Melissa; Boudoux, Caroline; Yachimski, P.S.; Puricelli, W.P.; Nishioka, Norman Shizuaki; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Bouma, Brett; Tearney, Guillermo James (Wiley-Blackwell, 2010)
      Spectrally encoded confocal microscopy and optical frequency domain imaging are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for ...
    • Columnar-lined esophagus in Chinese patients with proximal gastric carcinomas 

      Sun, Qi; Huang, Qin; Feng, An Ning; Fan, Xiang Shan; Wu, Hong Yan; Mashimo, Hiroshi; Zhou, Qiang; Chen, Jin; Lauwers, Gregory Y. (Wiley-Blackwell, 2012)
      Objective: To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. Methods: Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 ...
    • Comparison of a Lymph Node Ratio–Based Staging System With the 7th AJCC System for Gastric Cancer 

      Wang, Jiping; Dang, Ping; Raut, Chandrajit P; Pandalai, Prakash K.; Maduekwe, Ugwuji N.; Rattner, David William; Lauwers, Gregory Y.; Yoon, Sam (Ovid Technologies (Wolters Kluwer Health), 2012)
      OBJECTIVES: The American Joint Committee on Cancer (AJCC) staging system for gastric cancer bases N status on absolute number of metastatic nodes, regardless of the number of examined nodes. We examined a modified staging ...
    • Comparison of gastro-oesophageal junction carcinomas in Chinese versus American patients 

      Huang, Qin; Fan, Xiangshan; Agoston, Agoston; Feng, Anning; Yu, Huiping; Lauwers, Gregory Y.; Zhang, Lihua; Odze, Robert D. (Wiley-Blackwell, 2011)
      Aims:  To compare the clinical and pathological features of gastro-oesophageal junction (GEJ) carcinomas in Chinese and American patients. Methods and results:  Eighty consecutive patients with a GEJ carcinoma (43 from ...