Now showing items 1-5 of 5

    • Acute Histologic Chorioamnionitis at Term: Nearly Always Noninfectious 

      Roberts, Drucilla Jane; Celi, Ann Catherine; Riley, Laura E.; Onderdonk, Andrew Bruce; Boyd, Theonia Kamman; Johnson, Lise Carolyn; Lieberman, Ellice S. (Public Library of Science, 2012)
      Background: The link between histologic acute chorioamnionitis and infection is well established in preterm deliveries, but less well-studied in term pregnancies, where infection is much less common. Methodology/Principal ...
    • High Prevalence of Hypertension and Placental Insufficiency, but No In Utero HIV Transmission, among Women on HAART with Stillbirths in Botswana 

      Souda, Sajini; Parekh, Natasha; Binda, Kelebogile; Kayembe, Mukendi; Svab, Petr; Babitseng, Orphinah; Jimbo, William; Creek, Tracy; Essex, Max; Shapiro, Roger L.; Lockman, Shahin; Powis, Kathleen Marie; Makhema, Joseph Moeketsi; Roberts, Drucilla Jane (Public Library of Science, 2012)
      Background: Increased stillbirth rates occur among HIV-infected women, but no studies have evaluated the pathological basis for this increase, or whether highly active antiretroviral therapy (HAART) influences the etiology ...
    • Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice 

      Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D. (Public Library of Science, 2016)
      Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral ...
    • Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/\(\beta\)-Catenin and PTEN 

      Tanwar, Pradeep; Zhang, LiHua; Kaneko-Tarui, Tomoko; Curley, Michael D.; Taketo, Makoto M.; Rani, Poonam; Roberts, Drucilla Jane; Teixeira, Jose M. (Public Library of Science, 2011)
      Despite the fact that epithelial ovarian cancers are the leading cause of death from gynecological cancer, very little is known about the pathophysiology of the disease. Mutations in the WNT and PI3K pathways are frequently ...
    • Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania 

      Wylie, Blair J.; Matechi, Emmanuel; Kishashu, Yahya; Fawzi, Wafaie; Premji, Zul; Coull, Brent A.; Hauser, Russ; Ezzati, Majid; Roberts, Drucilla J. (National Institute of Environmental Health Sciences, 2016)
      Background: Smoke from the burning of biomass fuels has been linked with adverse pregnancy outcomes such as low birth weight, stillbirth, and prematurity. Objective: To identify potential underlying mechanisms of adverse ...