Browsing by Author "Aderman, Christopher"
Now showing items 1-3 of 3
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DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways
SanGiovanni, John Paul; Chen, Jing; Sapieha, Przemyslaw; Aderman, Christopher; Stahl, Andreas; Clemons, Traci E.; Chew, Emily Y.; Smith, Lois Elaine Hodgson (Public Library of Science (PLoS), 2013)BACKGROUND: Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal ... -
A Mechanosensitive Transcriptional Mechanism That Controls Angiogenesis
Mammoto, Akiko; Connor, Kip; Mammoto, Tadanori; Yung, Chong W.; Huh, Dongeun; Aderman, Christopher Michael; Mostoslavsky, Gustavo; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Nature Publishing Group, 2009)Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other ... -
Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy Clinical Perspective
Chen, Jing; Stahl, Andreas; Krah, Nathan M.; Seaward, Molly R.; Dennison, Roberta; Sapieha, Przemyslaw; Hua, Jing; Hatton, Colman J.; Juan, Aimee M.; Aderman, Christopher; Willett, Keirnan L.; Guerin, Karen I.; Mammoto, Akiko; Campbell, Matthew; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)BACKGROUND: Ischemic proliferative retinopathy, characterized by pathological retinal neovascularization, is a major cause of blindness in working-age adults and children. Defining the molecular pathways distinguishing ...