Browsing by Author "Pastor, William Abraham"

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    • The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing 

      Huang, Yun; Pastor, William Abraham; Shen, Yinghua; Tahiliani, Mamta V.; Liu, David Ruchien; Rao, Anjana; Liu, Jun (Public Library of Science, 2010)
      Background: We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and Purkinje neurons. The methylation status of ...

    • Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 

      Tahiliani, Mamta V.; Koh, Kian Peng; Shen, Yinghua; Pastor, William Abraham; Bandukwala, Hozefa S; Brudno, Yevgeny; Agarwal, Suneet; Iyer, Lakshminarayan M.; Liu, David Ruchien; Aravind, L; Rao, Anjana (American Association for the Advancement of Science, 2009)
      DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs ...