Now showing items 1-2 of 2

    • Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers 

      Raeder, Maria B.; Birkeland, Even; Trovik, Jone; Krakstad, Camilla; Shehata, Shyemaa; Schumacher, Steven; Zack, Travis Ian; Krohn, Antje; Werner, Henrica MJ.; Moody, Susan E; Wik, Elisabeth; Stefansson, Ingunn M.; Holst, Frederik; Oyan, Anne M.; Tamayo, Pablo; Mesirov, Jill; Kalland, Karl H.; Akslen, Lars A.; Simon, Ronald; Beroukhim, Rameen; Salvesen, Helga B. (Public Library of Science, 2013)
      Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most ...
    • PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling 

      Moody, Susan E.; Schinzel, Anna C.; Singh, Shambhavi; Izzo, Francesca; Strickland, Matthew R.; Luo, Leo; Thomas, Sapana R.; Boehm, Jesse S.; Kim, So Young; Wang, Zhigang C.; Hahn, William C. (2014)
      Targeting HER2 with antibodies or small molecule inhibitors in HER2-positive breast cancer leads to improved survival, but resistance is a common clinical problem. To uncover novel mechanisms of resistance to anti-HER2 ...