Browsing by Author "Macklis, Jeffrey"
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Anatomic and Molecular Development of Corticostriatal Projection Neurons in Mice
Sohur, Usharbudh Shivraj; Padmanabhan, Hari; Kotchetkov, Ivan S.; Menezes, Joao R.L.; Macklis, Jeffrey Daniel (Oxford University Press, 2013-03-18)Corticostriatal projection neurons (CStrPN) project from the neocortex to ipsilateral and contralateral striata to control and coordinate motor programs and movement. They are clinically important as the predominant cortical ... -
Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI
Tomassy, G. S.; De Leonibus, E.; Jabaudon, D.; Lodato, Simona; Alfano, C.; Mele, A.; Macklis, Jeffrey Daniel; Studer, M. (Proceedings of the National Academy of Sciences, 2010)Transcription factors with gradients of expression in neocortical progenitors give rise to distinct motor and sensory cortical areas by controlling the area-specific differentiation of distinct neuronal subtypes. However, ... -
Bhlhb5 Regulates the Postmitotic Acquisition of Area Identities in Layers II-V of the Developing Neocortex
Joshi, Pushkar S.; Molyneaux, Bradley John; Feng, Liang; Xie, Xiaoliang Sunney; Macklis, Jeffrey Daniel; Gan, Lin (Elsevier, 2008)While progenitor-restricted factors broadly specify area identities in developing neocortex, the downstream regulatory elements involved in acquisition of those identities in post-mitotic neurons are largely unknown. Here, ... -
Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity
Fame, Ryan Marie; MacDonald, Jessica Linn; Dunwoodie, S. L.; Oki, Emi Takahashi; Macklis, Jeffrey Daniel (Society for Neuroscience, 2016)The neocortex contains hundreds to thousands of distinct subtypes of precisely connected neurons, allowing it to perform remarkably complex tasks of high-level cognition. Callosal projection neurons (CPN) connect the ... -
Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in \(hSOD1^{G93A}\) Transgenic ALS Mice
Özdinler, P. Hande; Benn, Susanna; Yamamoto, Ted H.; Güzel, Mine; Brown Jr., Robert H.; Macklis, Jeffrey Daniel (Society for Neuroscience, 2011)Amyotrophic lateral sclerosis (ALS) is characterized by predominant vulnerability and central degeneration of both corticospinal/corticobulbar motor neurons (CSMN; “upper motor neurons”) in cerebral cortex, and spinal/bulbar ... -
Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function
Jara, Javier H.; Genç, Barış; Cox, Gregory; Bohn, Martha C.; Roos, Raymond P.; Macklis, Jeffrey Daniel; Ulupınar, Emel; Hande Ozdinler, P. (Oxford University Press, 2015)Corticospinal motor neurons (CSMN) receive, integrate, and relay cerebral cortex's input toward spinal targets to initiate and modulate voluntary movement. CSMN degeneration is central for numerous motor neuron disorders ... -
Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity
Galazo, Maria Jose; Emsley, Jason G.; Macklis, Jeffrey Daniel (Elsevier BV, 2016)Corticothalamic projection neurons (CThPN) are a diverse set of neurons, critical for function of the neocortex. CThPN development and diversity need to be precisely regulated, but little is known about molecular controls ... -
Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex
Greig, Luciano C.; Woodworth, Mollie Ann; Greppi, Chloe Charlotte; Macklis, Jeffrey Daniel (Elsevier BV, 2016)While several transcriptional controls over the size and relative position of cortical areas have been identified, less is known about regulators that direct acquisition of area-specific characteristics. Here, we report ... -
Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers
Woodworth, Mollie Ann; Greig, Luciano C.; Liu, Kevin Xinye; Ippolito, Gregory C.; Tucker, Haley O.; Macklis, Jeffrey Daniel (Elsevier BV, 2016)The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor ... -
Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum
Arlotta, Paola; Molyneaux, Bradley John; Jabaudon, Denis; Yoshida, Yutaka; Macklis, Jeffrey Daniel (Society for Neuroscience, 2008)Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington's disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is ... -
Deciphering Amyotrophic Lateral Sclerosis: What Phenotype, Neuropathology and Genetics Are Telling Us about Pathogenesis
Ravits, John; Appel, Stanley; Baloh, Robert H.; Barohn, Richard; Brooks, Benjamin Rix; Elman, Lauen; Floeter, Mary Kay; Macklis, Jeffrey Daniel; Henderson, Christopher; Lomen-Hoerth, Catherine; Mccluskey, Leo; Mitsumoto, Hiroshi; Prezedborski, Serge; Rothstein, Jeffrey; Trojanowski, John; Van Den Berg, Leonard; Ringel, Steven (Informa, 2013)Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive weakness and neuropathologically by loss of motor neurons. Phenotypically, there is marked heterogeneity. Typical ALS has mixed upper motor ... -
Development, specification, and diversity of callosal projection neurons
Fame, Ryann M.; MacDonald, Jessica Linn; Macklis, Jeffrey Daniel (Elsevier, 2011)Callosal projection neurons (CPN) are a diverse population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative ... -
Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice
Sohur, Usharbudh Shivraj; Arlotta, Paola; Macklis, Jeffrey Daniel (Frontiers Research Foundation, 2012)Whether induction of low-level neurogenesis in normally non-neurogenic regions of the adult brain mimics aspects of developmental neurogenesis is currently unknown. Previously, we and others identified that biophysically ... -
Directed differentiation of mouse embryonic stem cells into neocortical output neurons
Sadegh, Cameron (2013-10-18)During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons ... -
Established Monolayer Differentiation of Mouse Embryonic Stem Cells Generates Heterogeneous Neocortical-Like Neurons Stalled at a Stage Equivalent to Midcorticogenesis
Sadegh, Cameron; Macklis, Jeffrey Daniel (Wiley-Blackwell, 2014)By assessing multiple positive and negative markers of forebrain progenitors and neurons, the authors show that now-standard, partially directed neocortical differentiation of mouse embryonic stem cells generates neurons ... -
Human Adult Olfactory Bulb Neurogenesis? Novelty Is the Best Policy
Macklis, Jeffrey Daniel (Elsevier, 2012)There is ongoing controversy as to whether the understanding of adult mammalian neurogenesis gained from rodent studies is applicable to humans. In this issue of Neuron, Bergmann et al. (2012) propose that adult human ... -
Identification of Radial Glia-like Cells in the Adult Mouse Olfactory Bulb
Emsley, Jason G.; Menezes, João R.L.; Madeiro Da Costa, Rodrigo F.; Martinez, Ana Maria Blanco; Macklis, Jeffrey Daniel (Elsevier, 2012)Immature neurons migrate tangentially within the rostral migratory stream (RMS) to the adult olfactory bulb (OB), then radially to their final positions as granule and periglomerular neurons; the controls over this transition ... -
LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11
Muralidharan, Bhavana; Khatri, Zeba; Maheshwari, Upasana; Gupta, Ritika; Roy, Basabdatta; Pradhan, Saurabh J.; Karmodiya, Krishanpal; Padmanabhan, Hari; Shetty, Ashwin S.; Balaji, Chinthapalli; Kolthur-Seetharam, Ullas; Macklis, Jeffrey D.; Galande, Sanjeev; Tole, Shubha (Society for Neuroscience, 2017)In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with unique molecular identities. The regulatory changes that occur ... -
Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development
Azim, Eiman; Shnider, Sara J.; Cederquist, Gustav Y.; Sohur, Usharbudh Shivraj; Macklis, Jeffrey Daniel (Oxford University Press (OUP), 2009)Molecular controls over the development of the exceptional neuronal subtype diversity of the cerebral cortex are now beginning to be identified. The initial subtype fate decision early in the life of a neuron, and the ... -
Lmo4 Establishes Rostral Motor Cortex Projection Neuron Subtype Diversity
Cederquist, G. Y.; Azim, E.; Shnider, S. J.; Padmanabhan, Hari; Macklis, Jeffrey Daniel (Society for Neuroscience, 2013)The mammalian neocortex is parcellated into anatomically and functionally distinct areas. The establishment of area-specific neuronal diversity and circuit connectivity enables distinct neocortical regions to control diverse ...