Now showing items 1-6 of 6

    • Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome 

      Wang, Z. C.; Birkbak, N; Culhane, Aedin; Drapkin, R; Fatima, Aquila; Tian, R; Schwede, M.; Alsop, K.; Daniels, K. E.; Piao, H.; Liu, Joy; Etemadmoghadam, D.; Miron, A; Salvesen, H. B.; Mitchell, G.; DeFazio, A.; Quackenbush, John; Berkowitz, Ross Stuart; Iglehart, James Dirk; Bowtell, D. D. L.; Matulonis, Ursula Anne (American Association for Cancer Research (AACR), 2012)
      Purpose—High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination repair (HRR) are associated with genomic instability in ...
    • Recursive SVM Feature Selection and Sample Classification for Mass-Spectrometry and Microarray Data 

      Zhang, Xuegong; Lu, Xin; Shi, Qian; Xu, Xiu-qin; Leung, Hon-chiu E; Harris, Lyndsay N; Iglehart, James Dirk; Miron, Alexander; Liu, Jun; Wong, Wing H. (BioMed Central, 2006)
      Background: Like microarray-based investigations, high-throughput proteomics techniques require machine learning algorithms to identify biomarkers that are informative for biological classification problems. Feature selection ...
    • RelA-Induced Interferon Response Negatively Regulates Proliferation 

      Kochupurakkal, Bose S; Wang, Zhigang C.; Hua, Tony; Culhane, Aedin; Rodig, Scott J.; Rajkovic-Molek, Koraljka; Lazaro, Jean-Bernard; Richardson, Andrea; Biswas, Debajit Kumar; Iglehart, James Dirk (Public Library of Science (PLoS), 2015)
      Both oncogenic and tumor-suppressor activities are attributed to the Nuclear Factor kappa B (NF-kB) pathway. Moreover, NF-kB may positively or negatively regulate proliferation. The molecular determinants of these opposing ...
    • Risk Prediction Models with Incomplete Data with Application to Prediction of Estrogen Receptor-Positive Breast Cancer: Prospective Data from the Nurses' Health Study 

      Rosner, Bernard Alfred; Colditz, Graham A.; Iglehart, James Dirk; Hankinson, Susan Elizabeth (BioMed Central, 2008)
      Introduction: A number of breast cancer risk prediction models have been developed to provide insight into a woman's individual breast cancer risk. Although circulating levels of estradiol in postmenopausal women predict ...
    • Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? 

      Westover, Kenneth Dale; Westover, Michael Brandon; Winer, Eric Paul; Richardson, Andrea Lynn; Iglehart, James Dirk; Punglia, Rinaa S. (SAGE-Hindawi Access to Research, 2011)
      A negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on ...
    • Therapeutic Implications of GIPC1 Silencing in Cancer 

      Chittenden, Thomas W.; Pak, Jane; Rubio, Renee; Holton, Kristina; Prendergast, Niall; Glinskii, Vladimir; Schwede, Mathew; Howe, Eleanor A.; Aryee, Martin; Sultana, Razvan; Lanahan, Anthony A.; Holmes, Chris; Cheng, Hailing; Cai, Yi; Culhane, Aedin; Bentink, Stefan; Mar, Jessica Cara; Taylor, Jennifer; Hahn, William C.; Zhao, Jean J.; Iglehart, James Dirk; Quackenbush, John (Public Library of Science, 2010)
      GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human ...