Browsing by Author "Mizoguchi, Emiko"
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Animal models of ulcerative colitis and their application in drug research
Low, Daren; Nguyen, Deanna D; Mizoguchi, Emiko (Dove Medical Press, 2013)The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, ... -
Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9
Low, Daren; Subramaniam, Renuka; Lin, Li; Aomatsu, Tomoki; Mizoguchi, Atsushi; Ng, Aylwin; DeGruttola, Arianna K.; Lee, Chun Geun; Elias, Jack A.; Andoh, Akira; Mino-Kenudson, Mari; Mizoguchi, Emiko (Impact Journals LLC, 2015)Many host-factors are inducibly expressed during the development of inflammatory bowel disease (IBD), each having their unique properties, such as immune activation, bacterial clearance, and tissue repair/remodeling. ... -
Chitinase 3-Like 1 Promotes Macrophage Recruitment and Angiogenesis in Colorectal Cancer
Kawada, Mayumi; Seno, Hiroshi; Kanda, Keitaro; Nakanishi, Yuki; Akitake, Reiko; Komekado, Hideyuki; Kawada, Kenji; Sakai, Yoshiharu; Chiba, Tsutomu; Mizoguchi, Emiko (Nature Publishing Group, 2012)Chitinase 3-like 1 (CHI3L1), one of mammalian members of the chitinase family, is expressed in several types of human cancer, and elevated serum level of CHI3L1 is suggested to be a biomarker of poor prognosis in advanced ... -
High Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Mice
Low, Daren; DeGruttola, Arianna K.; Poltrak, Alexander; Mizoguchi, Atsushi; Mino-Kenudson, Mari; Mizoguchi, Emiko (Public Library of Science, 2015)Colorectal cancer (CRC) development is mediated by uncontrolled survival and proliferation of tumor progenitor cells. Using animal models to identify and study host-derived factors that underlie this process can aid ... -
Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells
Nishida, Atsushi; Nagahama, Kiyotaka; Imaeda, Hirotsugu; Ogawa, Atsuhiro; Lau, Cindy W.; Kobayashi, Taku; Hisamatsu, Tadakazu; Preffer, Frederic I.; Mizoguchi, Emiko; Ikeuchi, Hiroki; Hibi, Toshifumi; Fukuda, Minoru; Andoh, Akira; Blumberg, Richard S.; Mizoguchi, Atsushi (The Rockefeller University Press, 2012)Immune responses are modified by a diverse and abundant repertoire of carbohydrate structures on the cell surface, which is known as the glycome. In this study, we propose that a unique glycome that can be identified through ...