Now showing items 1-11 of 11

    • AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair 

      Cha, Jong-Ho; Wee, Hee-Jun; Seo, Ji Hae; Ahn, Bum Ju; Park, Ji-Hyeon; Yang, Jun-Mo; Lee, Sae-Won; Kim, Eun Hee; Lee, Ok-Hee; Heo, Ji Hoe; Lee, Hyo-Jong; Gelman, Irwin H.; Arai, Ken; Lo, Eng H.; Kim, Kyu-Won (Public Library of Science, 2014)
      The repair process after CNS injury shows a well-organized cascade of three distinct stages: inflammation, new tissue formation, and remodeling. In the new tissue formation stage, various cells migrate and form the fibrotic ...
    • CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation 

      Hayakawa, Kazuhide; Pham, Loc-Duyen; Seo, Ji-Hae; Miyamoto, Nobukazu; Maki, Takakuni; Sakadzic, Sava; Boas, David A.; van Leyen, Klaus J.; Waeber, Christian; Kim, Kyu-Won; Arai, Ken; Lo, Eng H. (SAGE Publications, 2016)
      There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ...
    • Combination Therapy with Normobaric Oxygen (NBO) Plus Thrombolysis in Experimental Ischemic Stroke 

      Fujiwara, Norio; Murata, Yoshihiro; Arai, Ken; Egi, Yasuhiro; Lu, Jie; Wu, Ona; Singhal, Aneesh B.; Lo, Eng H. (BioMed Central, 2009)
      Background: The widespread use of tissue plasminogen activator (tPA), the only FDA-approved acute stroke treatment, remains limited by its narrow therapeutic time window and related risks of brain hemorrhage. Normobaric ...
    • Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells 

      Koh, Seong-Ho; Liang, Anna C.; Takahashi, Yoko; Maki, Takakuni; Shindo, Akihiro; Osumi, Noriko; Zhao, Jing; Lin, Hong; Holder, Julie C.; Chuang, Tsu Tshen; McNeish, John D.; Arai, Ken; Lo, Eng H. (Public Library of Science, 2015)
      Adult mammalian brain can be plastic after injury and disease. Therefore, boosting endogenous repair mechanisms would be a useful therapeutic approach for neurological disorders. Isoxazole-9 (Isx-9) has been reported to ...
    • Experimental Models for Analysis of Oligodendrocyte Pathophysiology in Stroke 

      Arai, Ken; Lo, Eng H. (BioMed Central, 2009)
      White matter damage is a clinically important part of stroke. However, compared to the mechanisms of neuronal injury in gray matter, white matter pathophysiology remains relatively understudied and poorly understood. This ...
    • First translational ‘Think Tank’ on cerebrovascular disease, cognitive impairment and dementia 

      Barone, Frank C.; Gustafson, Deborah; Crystal, Howard A.; Moreno, Herman; Adamski, Mateusz G.; Arai, Ken; Baird, Alison E.; Balucani, Clotilde; Brickman, Adam M.; Cechetto, David; Gorelick, Philip; Biessels, Geert Jan; Kiliaan, Amanda; Launer, Lenore; Schneider, Julie; Sorond, Farzaneh A.; Whitmer, Rachel; Wright, Clinton; Zhang, Zheng Gang (BioMed Central, 2016)
      Abstract and introduction to the workshop As the human population continues to age, an increasing number of people will exhibit significant deficits in cognitive function and dementia. It is now recognized that cerebrovascular, ...
    • Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice 

      Foerch, Christian; Rosidi, Nathanael L.; Schlunk, Frieder; Lauer, Arne; Cianchetti, Flor A.; Mandeville, Emiri T; Arai, Ken; Yigitkanli, Kazim; Fan, Xiang; Wang, Xiaoying; van Leyen, Klaus J.; Steinmetz, Helmuth; Schaffer, Chris B.; Lo, Eng H. (Public Library of Science, 2013)
      Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral ...
    • Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases 

      Maki, Takakuni; Liang, Anna C.; Miyamoto, Nobukazu; Lo, Eng H.; Arai, Ken (Frontiers Media S.A., 2013)
      White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at ...
    • Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling 

      Seo, Ji Hae; Maki, Takakuni; Maeda, Mitsuyo; Miyamoto, Nobukazu; Liang, Anna C.; Hayakawa, Kazuhide; Pham, Loc-Duyen D.; Suwa, Fumihiko; Taguchi, Akihiko; Matsuyama, Tomohiro; Ihara, Masafumi; Kim, Kyu-Won; Lo, Eng H.; Arai, Ken (Public Library of Science, 2014)
      Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) ...
    • Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid 

      Maki, Takakuni; Okamoto, Yoko; Carare, Roxana O; Hase, Yoshiki; Hattori, Yorito; Hawkes, Cheryl A; Saito, Satoshi; Yamamoto, Yumi; Terasaki, Yasukazu; Ishibashi-Ueda, Hatsue; Taguchi, Akihiko; Takahashi, Ryosuke; Miyakawa, Taihei; Kalaria, Raj N; Lo, Eng H; Arai, Ken; Ihara, Masafumi (Blackwell Publishing Ltd, 2014)
      Objective: Brain amyloidosis is a key feature of Alzheimer's disease (AD). It also incorporates cerebrovascular amyloid β (Aβ) in the form of cerebral amyloid angiopathy (CAA) involving neurovascular dysfunction. We have ...
    • Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology 

      Cho, Hansang; Seo, Ji Hae; Wong, Keith H. K.; Terasaki, Yasukazu; Park, Joseph; Bong, Kiwan; Arai, Ken; Lo, Eng H.; Irimia, Daniel (Nature Publishing Group, 2015)
      Blood–brain barrier (BBB) pathology leads to neurovascular disorders and is an important target for therapies. However, the study of BBB pathology is difficult in the absence of models that are simple and relevant. In vivo ...