Now showing items 1-9 of 9

    • Elevated Levels of Interferon-γ Production by Memory T Cells Do Not Promote Transplant Tolerance Resistance in Aged Recipients 

      Kim, James I.; Stott, Ryan T.; Soohoo, Julie; Lee, Kang Mi; Zhao, Gaoping; Yeh, Heidi; Deng, Shaoping; Markmann, James F. (Public Library of Science, 2013)
      Immunosenescence predisposes the elderly to infectious and autoimmune diseases and impairs the response to vaccination. We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike ...
    • Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells 

      Lee, Jonghyeob; Sugiyama, Takuya; Liu, Yinghua; Wang, Jing; Gu, Xueying; Lei, Ji; Markmann, James F; Miyazaki, Satsuki; Miyazaki, Jun-ichi; Szot, Gregory L; Bottino, Rita; Kim, Seung K (eLife Sciences Publications, Ltd, 2013)
      Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus, functional β-cell replacement from renewable sources is the focus of intensive worldwide effort. However, in vitro production of ...
    • Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion 

      Bruinsma, Bote G.; Avruch, James H.; Weeder, Pepijn D.; Sridharan, Gautham V.; Uygun, Basak E.; Karimian, Negin G.; Porte, Robert J.; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (MyJove Corporation, 2015)
      There is currently a severe shortage of liver grafts available for transplantation. Novel organ preservation techniques are needed to expand the pool of donor livers. Machine perfusion of donor liver grafts is an alternative ...
    • IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response 

      Petrelli, Alessandra; Carvello, Michele; Du, Ming; Chengwen, Liu; Mfarrej, Bechara G.; Hwu, Patrick; Secchi, Antonio; Leonard, Warren J.; Young, Deborah; Zajac, Allan J.; Vergani, Andrea; Lee, Kang Mi; Tezza, Sara; Kleffel, Sonja Beate; Sayegh, Mohamed Hassan; Markmann, James F.; Fiorina, Paolo (American Diabetes Association, 2011)
      Objective: Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still ...
    • Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses 

      Carvello, Michele; Petrelli, Alessandra; Vergani, Andrea; Lee, Kang Mi; Tezza, Sara; Chin, Melissa; Orsenigo, Elena; Staudacher, Carlo; Secchi, Antonio; Dunussi-Joannopoulos, Kyri; Sayegh, Mohamed Hassan; Markmann, James F.; Fiorina, Paolo (American Diabetes Association, 2012)
      B cells participate in the priming of the allo- and autoimmune responses, and their depletion can thus be advantageous for islet transplantation. Herein, we provide an extensive study of the effect of B-cell depletion in ...
    • Mechanisms of Xenogeneic Baboon Platelet Aggregation and Phagocytosis by Porcine Liver Sinusoidal Endothelial Cells 

      Peng, Qiang; Yeh, Heidi; Wei, Lingling; Enjyoj, Keiichi; Machaidze, Zurab; Csizmad, Eva; Schuetz, Christian; Lee, Kang Mi; Deng, Shaoping; Robson, Simon Christopher; Markmann, James; Buhler, Leo (Public Library of Science, 2012)
      Background: Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. ...
    • Metabolic profiling during ex vivo machine perfusion of the human liver 

      Bruinsma, Bote G.; Sridharan, Gautham V.; Weeder, Pepijn D.; Avruch, James H.; Saeidi, Nima; Özer, Sinan; Geerts, Sharon; Porte, Robert J.; Heger, Michal; van Gulik, Thomas M.; Martins, Paulo N.; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (Nature Publishing Group, 2016)
      As donor organ shortages persist, functional machine perfusion is under investigation to improve preservation of the donor liver. The transplantation of donation after circulatory death (DCD) livers is limited by poor ...
    • Trends in the Management and Outcomes of Kidney Transplantation for Autosomal Dominant Polycystic Kidney Disease 

      Patel, Madhukar S.; Kandula, Praveen; Wojciechowski, David; Markmann, James F.; Vagefi, Parsia A. (Hindawi Publishing Corporation, 2014)
      Background. Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure. The objective of this study was to evaluate a longitudinal experience of kidney ...
    • Warm Ischemic Injury Is Reflected in the Release of Injury Markers during Cold Preservation of the Human Liver 

      Bruinsma, Bote G.; Wu, Wilson; Ozer, Sinan; Farmer, Adam; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (Public Library of Science, 2015)
      Background: Liver transplantation plays a pivotal role in the treatment of patients with end-stage liver disease. Despite excellent outcomes, the field is strained by a severe shortage of viable liver grafts. To meet high ...