Now showing items 1-4 of 4

    • BORIS Promotes Chromatin Regulatory Interactions in Treatment-Resistant Cancer Cells 

      Dries, Ruben; Seruggia, Davide; Gao, Yang; Sharma, Bandana; Huang, Hao; Moreau, Lisa; McLane, Michael; Marco, Eugenio; Chen, Ting; Yuan, Guo-Cheng; Young, Richard A.; Debruyne, David; Day, Daniel; Gray, Nathanael; Wong, Kwok-Kin; Orkin, Stuart; George, Rani; Sengupta, Satyaki (Springer Science and Business Media LLC, 2019-08)
      The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into structural domains, plays a central role in gene control by facilitating or constraining interactions between genes and their regulatory ...
    • Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis 

      Chastanet, A.; Vitkup, D.; Yuan, Guocheng; Norman, Thomas Maxwell; Liu, Jun; Losick, Richard M. (Proceedings of the National Academy of Sciences, 2010)
      A model system for investigating how developmental regulatory networks determine cell fate is spore formation in Bacillus subtilis. The master regulator for sporulation is Spo0A, which is activated by phosphorylation via ...
    • Chromatin States Accurately Classify Cell Differentiation Stages 

      Larson, Jessica Lynn; Yuan, Guocheng (Public Library of Science, 2012)
      Gene expression is controlled by the concerted interactions between transcription factors and chromatin regulators. While recent studies have identified global chromatin state changes across cell-types, it remains unclear ...
    • STAT5 Outcompetes STAT3 To Regulate the Expression of the Oncogenic Transcriptional Modulator BCL6 

      Walker, Sarah Rebecca; Nelson, E; Yeh, Jennifer E; Pinello, Luca; Yuan, Guocheng; Frank, David Alan (American Society for Microbiology, 2013)
      Inappropriate activation of the transcription factors STAT3 and STAT5 has been shown to drive cancer pathogenesis through dysregulation of genes involved in cell survival, growth, and differentiation. Although STAT3 and ...