Now showing items 1-12 of 12

    • Blood Donation and Colorectal Cancer Incidence and Mortality in Men 

      Zhang, Xuehong; Ma, Jing; Wu, Kana; Chan, Andrew Tan; Fuchs, Charles Stewart; Giovannucci, Edward L. (Public Library of Science, 2012)
      Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...
    • Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer 

      Figueiredo, Jane C.; Hsu, Li; Hutter, Carolyn M.; Lin, Yi; Campbell, Peter T.; Baron, John A.; Berndt, Sonja I.; Jiao, Shuo; Casey, Graham; Fortini, Barbara; Chan, Andrew T.; Cotterchio, Michelle; Lemire, Mathieu; Gallinger, Steven; Harrison, Tabitha A.; Le Marchand, Loic; Newcomb, Polly A.; Slattery, Martha L.; Caan, Bette J.; Carlson, Christopher S.; Zanke, Brent W.; Rosse, Stephanie A.; Brenner, Hermann; Giovannucci, Edward L.; Wu, Kana; Chang-Claude, Jenny; Chanock, Stephen J.; Curtis, Keith R.; Duggan, David; Gong, Jian; Haile, Robert W.; Hayes, Richard B.; Hoffmeister, Michael; Hopper, John L.; Jenkins, Mark A.; Kolonel, Laurence N.; Qu, Conghui; Rudolph, Anja; Schoen, Robert E.; Schumacher, Fredrick R.; Seminara, Daniela; Stelling, Deanna L.; Thibodeau, Stephen N.; Thornquist, Mark; Warnick, Greg S.; Henderson, Brian E.; Ulrich, Cornelia M.; Gauderman, W. James; Potter, John D.; White, Emily; Peters, Ulrike (Public Library of Science, 2014)
      Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk ...
    • Interactions between Plasma Levels of 25-Hydroxyvitamin D, Insulin-Like Growth Factor (IGF)-1 and C-Peptide with Risk of Colorectal Cancer 

      Wu, Kana; Feskanich, Diane; Fuchs, Charles Stewart; Chan, Andrew Tan; Willett, Walter C.; Hollis, Bruce W.; Pollak, Michael N.; Giovannucci, Edward L. (Public Library of Science, 2011)
      Background: Vitamin D status and levels of insulin-like growth factor (IGF)-1 and C-peptide have been implicated in colorectal carcinogenesis. However, in contrast to vitamin D IGF-1 is not an easily modifiable risk factor. ...
    • Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis 

      Kim, Sun A; Inamura, Kentaro; Yamauchi, Mai; Nishihara, Reiko; Mima, Kosuke; Sukawa, Yasutaka; Li, Tingting; Yasunari, Mika; Morikawa, Teppei; Fitzgerald, Kathryn C; Fuchs, Charles S; Wu, Kana; Chan, Andrew T; Zhang, Xuehong; Ogino, Shuji; Qian, Zhi Rong (Nature Publishing Group, 2016)
      Background: Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss of CDH1 expression in colorectal carcinoma might be associated with aggressive ...
    • Nut consumption and risk of colorectal cancer in women 

      Yang, Meng; Hu, Frank B.; Giovannucci, Edward L.; Stampfer, Meir; Willett, Walter C.; Fuchs, Charles Stewart; Wu, Kana; Bao, Ying (Nature Publishing Group, 2015)
      Background/Objectives: Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, which are risk factors for colorectal cancer. However, the association between nut consumption and ...
    • Oral Contraceptive Use and Colorectal Cancer in the Nurses' Health Study I and II 

      Charlton, Brittany Michelle; Wu, Kana; Zhang, Xuehong; Giovannucci, Edward L.; Fuchs, Charles Stewart; Missmer, Stacey Ann; Rosner, Bernard Alfred; Hankinson, Susan Elizabeth; Willett, Walter C.; Michels, Karin B. (American Association for Cancer Research (AACR), 2015)
      Background—It remains unclear if oral contraceptive (OC) use is associated with the incidence of colorectal cancer. Few studies have examined this association by duration of OC use, time since last OC use, and different ...
    • Post Diagnosis Diet Quality and Colorectal Cancer Survival in Women 

      Fung, Teresa T.; Kashambwa, Rutendo; Sato, Kaori; Chiuve, Stephanie E.; Fuchs, Charles S.; Wu, Kana; Giovannucci, Edward; Ogino, Shuji; Hu, Frank B.; Meyerhardt, Jeffrey A. (Public Library of Science, 2014)
      Background: Dietary factors are known to influence colorectal cancer (CRC) risk, however, their association with CRC survival is unclear. Therefore, we prospectively examined the association between diet quality scores, ...
    • Pre-Diagnostic Leukocyte Genomic DNA Methylation and the Risk of Colorectal Cancer in Women 

      Nan, Hongmei; Giovannucci, Edward L.; Wu, Kana; Selhub, Jacob; Paul, Ligi; Rosner, Bernard Alfred; Fuchs, Charles Stewart; Cho, Eunyoung (Public Library of Science, 2013)
      Background: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. Methods: We evaluated the association between ...
    • Processed and Unprocessed Red Meat and Risk of Colorectal Cancer: Analysis by Tumor Location and Modification by Time 

      Bernstein, Adam M.; Song, Mingyang; Zhang, Xuehong; Pan, An; Wang, Molin; Fuchs, Charles S.; Le, Ngoan; Chan, Andrew T.; Willett, Walter C.; Ogino, Shuji; Giovannucci, Edward L.; Wu, Kana (Public Library of Science, 2015)
      Although the association between red meat consumption and colorectal cancer (CRC) is well established, the association across subsites of the colon and rectum remains uncertain, as does time of consumption in relation to ...
    • A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses’ Health Study and Health Professionals Follow-up Study 

      Le, Ngoan Tran; Michels, Fernanda Alessandra Silva; Song, Mingyang; Zhang, Xuehong; Bernstein, Adam M.; Giovannucci, Edward L.; Fuchs, Charles S.; Ogino, Shuji; Chan, Andrew T.; Sinha, Rashmi; Willett, Walter C.; Wu, Kana (National Institute of Environmental Health Sciences, 2016)
      Background: Heterocyclic amines (HCAs) in cooked meats may play a role in colorectal cancer (CRC) development. Objectives: We aimed to prospectively examine the association between estimated intakes of HCAs and meat-derived ...
    • A prospective study of oral contraceptive use and colorectal adenomas 

      Charlton, Brittany Michelle; Giovannucci, Edward L.; Fuchs, Charles Stewart; Chan, Andrew Tan; Lee, Jung; Cao, Yin; Missmer, Stacey Ann; Rosner, Bernard Alfred; Hankinson, Susan Elizabeth; Willett, Walter C.; Wu, Kana; Michels, Karin B. (Springer Nature, 2016)
      Purpose—The influence of reproductive factors on colorectal cancer, including oral contraceptive (OC) use, has been examined, but less research is available on OC use and adenomas. Methods—Participants of the Nurses' ...
    • Sugar-Sweetened Beverage Intake and Cancer Recurrence and Survival in CALGB 89803 (Alliance) 

      Fuchs, Michael A.; Sato, Kaori; Niedzwiecki, Donna; Ye, Xing; Saltz, Leonard B.; Mayer, Robert J.; Mowat, Rex B.; Whittom, Renaud; Hantel, Alexander; Benson, Al; Atienza, Daniel; Messino, Michael; Kindler, Hedy; Venook, Alan; Ogino, Shuji; Wu, Kana; Willett, Walter C.; Giovannucci, Edward L.; Meyerhardt, Jeffrey A. (Public Library of Science, 2014)
      Background: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated ...