Now showing items 1-4 of 4

    • GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses 

      Chiang, Hao-Sen; Zhao, Yun; Song, Joo-Hye; Liu, Song; Wang, Ninghai; Terhorst, Cox; Sharpe, Arlene H.; Basavappa, Megha; Jeffrey, Kate L.; Reinecker, Hans-Christian (2014)
      Detailed understanding of the signaling intermediates that confer the sensing of intracellular viral nucleic acids for induction of type I interferons is critical for strategies to curtail viral mechanisms that impede ...
    • GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors 

      Fukazawa, Atsuko; Alonso, Carmen; Kurachi, Kiyotaka; Gupta, Sonal; Philpott, Dana J.; Lesser, Cammie; McCormick, Beth A.; Reinecker, Hans-Christian (Public Library of Science, 2008)
      Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune ...
    • Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4+ T Cells 

      Liao, Gongxian; O’Keeffe, Michael S.; Wang, Guoxing; van Driel, Boaz; de Waal Malefyt, Rene; Reinecker, Hans-Christian; Herzog, Roland W.; Terhorst, Cox (Frontiers Media S.A., 2014)
      Glucocorticoid-induced tumor necrosis factor receptor family-related protein (TNFRSF18, CD357) is constitutively expressed on regulatory T cells (Tregs) and is inducible on effector T cells. In this report, we examine the ...
    • Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation 

      Chen, Xinhua; Yang, Guoxun; Song, Joo-Hye; Xu, Huansheng; Li, Dan; Goldsmith, Jeffrey David; Zeng, Huiyan; Parsons-Wingerter, Patricia A.; Reinecker, Hans-Christian; Kelly, Ciaran Patrick (Public Library of Science, 2013)
      Background and Aims Saccharomyces boulardii (Sb) can protect against intestinal injury and tumor formation, but how this probiotic yeast controls protective mucosal host responses is unclear. Angiogenesis is an integral ...