Browsing by Author "Hansen, Steen"
Now showing items 1-3 of 3
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High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs
Duda, Katarzyna; Lonowski, Lindsey A.; Kofoed-Nielsen, Michael; Ibarra, Adriana; Delay, Catherine M.; Kang, Qiaohua; Yang, Zhang; Pruett-Miller, Shondra M.; Bennett, Eric P.; Wandall, Hans H.; Davis, Gregory D.; Hansen, Steen H.; Frödin, Morten (Oxford University Press, 2014)Targeted endonucleases including zinc finger nucleases (ZFNs) and clustered regularly interspaced short palindromic repeats (CRISPRs)/Cas9 are increasingly being used for genome editing in higher species. We therefore ... -
Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression
Bellucci, Roberto; Martin, Allison; Bommarito, Davide; Wang, Kathy; Hansen, Steen H; Freeman, Gordon J; Ritz, Jerome (Taylor & Francis, 2015)Inhibition of JAK1 or JAK2 in human tumor cells was previously shown to increase susceptibility of these cells to NK cell lysis. In the present study, we examined the cellular mechanisms that mediate this effect in ... -
The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity
Tzaban, Salit; Massol, Ramiro; Yen, Elizabeth Hechavarria; Hamman, Wendy; Frank, Scott Randy; Lapierre, Lynne A.; Hansen, Steen Henning; Goldenring, James R.; Blumberg, Richard Steven; Lencer, Wayne Isaac (Rockefeller University Press, 2009)The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense. We show that FcRn traffics IgG from either apical or ...