Now showing items 1-4 of 4

    • Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis 

      Kostopoulou, Fotini; Gkretsi, Vasiliki; Malizos, Konstantinos N.; Iliopoulos, Dimitrios; Oikonomou, Pagona; Poultsides, Lazaros; Tsezou, Aspasia (Public Library of Science, 2012)
      Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ...
    • Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus 

      Nakou, Magdalene; Bertsias, George; Stagakis, Ilias; Centola, Michael; Tassiulas, Ioannis; Hatziapostolou, Maria; Kritikos, Iraklis; Goulielmos, George; Boumpas, Dimitrios T.; Iliopoulos, Dimitrios (Public Library of Science, 2010)
      Background: Gene profiling studies provide important information for key molecules relevant to a disease but are less informative of protein-protein interactions, post-translational modifications and regulation by targeted ...
    • MicroRNA Gene Networks in Oncogenesis 

      Drakaki, Alexandra; Iliopoulos, Dimitrios (Bentham Science Publishers Ltd, 2009)
      MicroRNAs are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. They are involved in cellular development, differentiation, proliferation and apoptosis and play a ...
    • MiR-27b targets PPARγ to inhibit growth, tumor progression, and the inflammatory response in neuroblastoma cells 

      Lee, Jia Jing; Drakaki, Alexandra; Iliopoulos, Dimitrios; Struhl, Kevin (2011)
      The PPARγ nuclear receptor pathway is involved in cancer, but it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells, miR-27b targets the 3′UTR of PPARγ and inhibits its mRNA and protein ...