Now showing items 1-6 of 6

    • Angiotensin II Induced Cardiac Dysfunction on a Chip 

      Horton, Renita E.; Yadid, Moran; McCain, Megan L.; Sheehy, Sean P.; Pasqualini, Francesco S.; Park, Sung-Jin; Cho, Alexander; Campbell, Patrick; Parker, Kevin Kit (Public Library of Science, 2016)
      In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ...
    • Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy 

      Aratyn-Schaus, Yvonne; Pasqualini, Francesco S.; Yuan, Hongyan; McCain, Megan L.; Ye, George J.C.; Sheehy, Sean P.; Campbell, Patrick H.; Parker, Kevin Kit (The Rockefeller University Press, 2016)
      The efficacy of cardiac cell therapy depends on the integration of existing and newly formed cardiomyocytes. Here, we developed a minimal in vitro model of this interface by engineering two cell microtissues (μtissues) ...
    • Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing 

      Lind, Johan Ulrik; Busbee, Travis Alexander; Valentine, Alexander; Pasqualini, Francesco; Yuan, Hongyan; Yedid, Moran; Park, Sung-Jin; Kotikian, Arda; Nesmith, Alexander Peyton; Campbell, Patrick H.; Vlassak, Joost J.; Lewis, Jennifer; Parker, Kevin Kit (Springer Nature, 2016)
      Biomedical research has relied on animal studies and conventional cell cultures for decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that recapitulate the structure and function of native ...
    • Mechanotransduction and Metabolism in Cardiomyocyte Microdomains 

      Pasqualini, Francesco S.; Nesmith, Alexander P.; Horton, Renita E.; Sheehy, Sean P.; Parker, Kevin Kit (Hindawi Publishing Corporation, 2016)
      Efficient contractions of the left ventricle are ensured by the continuous transfer of adenosine triphosphate (ATP) from energy production sites, the mitochondria, to energy utilization sites, such as ionic pumps and the ...
    • Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies 

      Wang, Gang; McCain, Megan L.; Yang, Luhan; He, Aibin; Pasqualini, Francesco Silvio; Agarwal, Ashutosh; Yuan, Hongyan; Jiang, Dawei; Zhang, Donghui; Zangi, Lior; Geva, Judith; Roberts, Amy E.; Ma, Qing; Ding, Jian; Chen, Jinghai; Wang, Da-zhi; Li, Kai; Wang, Jiwu; Wanders, Ronald J. A.; Kulik, Wim; Vaz, Frédéric M.; Laflamme, Michael A.; Murry, Charles E.; Chien, Kenneth R.; Kelley, Richard I.; Church, George M.; Parker, Kevin Kit; Pu, William T. (2014)
      Studying monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial roles in cardiac development and disease. Here, we combine patient-derived and genetically engineered iPSCs with tissue engineering ...
    • Quality Metrics for Stem Cell-Derived Cardiac Myocytes 

      Sheehy, Sean P.; Pasqualini, Francesco; Grosberg, Anna; Park, Sung Jin; Aratyn-Schaus, Yvonne; Parker, Kevin Kit (Elsevier, 2014)
      Summary Advances in stem cell manufacturing methods have made it possible to produce stem cell-derived cardiac myocytes at industrial scales for in vitro muscle physiology research purposes. Although FDA-mandated quality ...