Now showing items 1-20 of 22

    • Abacavir Alters the Transcription of Inflammatory Cytokines in Virologically Suppressed, HIV-Infected Women 

      MacLeod, Iain James; Rowley, Christopher Francis; Lockman, Shahin; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Makhema, Joseph Moeketsi; Essex, Myron Elmer; Shapiro, Roger L. (International AIDS Society, 2012)
      Background: Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation. Methods: To evaluate the induction of inflammatory ...
    • Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2 

      Celum, C.; Wald, A.; Lingappa, J.R.; Magaret, A.S.; Wang, R.S.; Mugo, N.; Mujugira, A.; Baeten, J.M.; Mullins, J.I.; Hughes, J.P.; Bukusi, E.A.; Cohen, C.R.; Katabira, E.; Ronald, A.; Kiarie, J.; Farquhar, C.; Stewart, G.J.; Makhema, Joseph Moeketsi; Essex, Myron Elmer; Were, E.; Fife, K.H.; de Bruyn, G.; Gray, G.E.; McIntyre, J.A.; Manongi, R.; Kapiga, S.; Coetzee, D.; Allen, S.; Inambao, M.; Kayitenkore, K.; Karita, E.; Kanweka, W.; Delany, S.; Rees, H.; Vwalika, B.; Stevens, W.; Campbell, M.S.; Thomas, K.K.; Coombs, R.W.; Morrow, R.; Whittington, W.L.H.; McElrath, M.J.; Barnes, L.; Ridzon, R.; Corey, L. (New England Journal of Medicine (NEJM/MMS), 2010)
      BACKGROUND: Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma ...
    • Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana 

      Shapiro, R.L.; Hughes, M.D.; Ogwu, Anthony; Kitch, Doug William; Lockman, Shahin; Moffat, C.; Makhema, Joseph Moeketsi; Moyo, S; Thior, Ibou; McIntosh, Kenneth; van Widenfelt, E.; Leidner, Jean A.; Powis, Kathleen Marie; Asmelash, A.; Tumbare, E.; Zwerski, S.; Sharma, Upasna; Handelsman, E.; Mburu, K.; Jayeoba, O.; Moko, E.; Souda, Shashidhar Vaman; Lubega, E.; Akhtar, M.; Wester, C William; Tuomola, R.; Snowden, W.; Martinez-Tristani, M.; Mazhani, L.; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2010)
      BACKGROUND: The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are ...
    • Birth Weight for Gestational Age Norms for a Large Cohort of Infants Born to HIV-Negative Women in Botswana Compared with Norms for U.S.-Born Black Infants 

      Parekh, Natasha K; Binda, Kelebogile; Souda, Sajini; Essex, Max; Matthews, Lynn Turner; Ribaudo, Heather J.; Chen, Jennifer Yin-zu; Ogwu, Anthony; Makhema, Joseph Moeketsi; Lockman, Shahin; Shapiro, Roger L. (BioMed Central, 2011)
      Background: Standard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, ...
    • Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study 

      Lingappa, Jairam R.; Kahle, Erin; Mugo, Nelly; Mujugira, Andrew; Magaret, Amalia; Baeten, Jared; Bukusi, Elizabeth A.; Cohen, Craig R.; Katabira, Elly; Ronald, Allan; Kiarie, James; Farquhar, Carey; Stewart, Grace John; Were, Edwin; Fife, Kenneth; deBruyn, Guy; Gray, Glenda; Manongi, Rachel; Coetzee, David; Allen, Susan; Inambao, Mubiana; Kayitenkore, Kayitesi; Karita, Etienne; Kanweka, William; Delany, Sinead; Rees, Helen; Vwalika, Bellington; Coombs, Robert W.; Morrow, Rhoda; Whittington, William; Corey, Lawrence; Wald, Anna; Celum, Connie; Emery, Sean; Makhema, Joseph Moeketsi; Essex, Myron Elmer; McIntyre, James Francis; Kapiga, Saidi Hussein (Public Library of Science, 2009)
      Background: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce ...
    • Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana 

      Baum, Marianna K.; Campa, Adriana; Lai, Shenghan; Sales Martinez, Sabrina; Tsalaile, Lesedi; Burns, Patricia Jeanne; Farahani, Mansour Safaie; Li, Yinghui; van Widenfelt, Erik; Page, John Bryan; Bussmann, Hermann; Fawzi, Wafaie W.; Moyo, Sikhulele; Makhema, Joseph Moeketsi; Thior, Ibou; Essex, Myron Elmer; Marlink, Richard G. (American Medical Association (AMA), 2013)
      IMPORTANCE Micronutrient deficiencies occur early in human immunodeficiency virus (HIV) infection, and supplementation with micronutrients may be beneficial; however, its effectiveness has not been investigated early ...
    • Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community 

      Novitsky, Vlad; Bussmann, Hermann; Okui, Lillian; Logan, Andrew; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Lei, Quanhong; Holme, Molly P; Makhema, Joseph; Lockman, Shahin; Degruttola, Victor; Essex, M (International AIDS Society, 2015)
      Introduction: It would be useful to understand which populations are not reached by home-based HIV-1 testing and counselling (HTC) to improve strategies aimed at linking these individuals to care and reducing rates of ...
    • Evaluation of the False Recent Classification Rates of Multiassay Algorithms in Estimating HIV Type 1 Subtype C Incidence 

      Moyo, Sikhulile; LeCuyer, Tessa; Wang, Rui; Gaseitsiwe, Simani; Weng, Jia; Musonda, Rosemary Mubanga; Bussmann, Hermann; Mine, Madisa; Engelbrecht, Susan; Makhema, Joseph Moeketsi; Marlink, Richard G.; Baum, Marianna K.; Novitsky, Vladimir A.; Essex, Myron Elmer (Mary Ann Liebert Inc, 2014)
      Laboratory cross-sectional assays are useful for the estimation of HIV incidence, but are known to misclassify individuals with long-standing infection as recently infected. The false recent rate (FRR) varies widely across ...
    • High Prevalence of Hypertension and Placental Insufficiency, but No In Utero HIV Transmission, among Women on HAART with Stillbirths in Botswana 

      Souda, Sajini; Parekh, Natasha; Binda, Kelebogile; Kayembe, Mukendi; Svab, Petr; Babitseng, Orphinah; Jimbo, William; Creek, Tracy; Essex, Max; Shapiro, Roger L.; Lockman, Shahin; Powis, Kathleen Marie; Makhema, Joseph Moeketsi; Roberts, Drucilla Jane (Public Library of Science, 2012)
      Background: Increased stillbirth rates occur among HIV-infected women, but no studies have evaluated the pathological basis for this increase, or whether highly active antiretroviral therapy (HAART) influences the etiology ...
    • HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission 

      Baum, Marianna; Thior, Ibou; Asmelash, Aida; Campa, Adriana; van Widenfelt, Erik; Mine, Madisa; Moffat, Claire; Mmalane, Mompati; Gilbert, Peter; Novitsky, Vladimir A.; Wang, Rui; Bussmann, Hermann; Lockman, Shahin; Shapiro, Roger L.; Wester, Carolyn Negley; Wester, C William; Ogwu, Anthony; Musonda, Rosemary Mubanga; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Marlink, Richard George; Seage, George R.; De Gruttola, Victor Gerard; Essex, Myron Elmer (Public Library of Science, 2010)
      The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in Botswana, the median baseline plasma ...
    • Immunohaematological reference values for HIV-negative healthy adults in Botswana 

      Mine, Madisa; Moyo, Sikhulile; Stevens, Penny; Michael, Kurt; Novitsky, Vladimir A.; Makhaola, Kgomotso; Asmelash, Aida; Molefhabangwe, S’khatele; Woldegabriel, Elias; Mothowaeng, Gaseboloke; Maruta, Talkmore; Kamhukamwe, Charity; Mangwendeza, Phibeon M.; Holmes-Pretorius, Molly; Mtoni, Isaac; Motswaledi, Modisa; Musonda, Rosemary Mubanga; Ndwapi, Ndwapi; Makhema, Joseph Moeketsi; Marlink, Richard G.; Seipone, Khumo; Gaolathe, Tendani; Essex, Myron Elmer (AOSIS, 2011)
      BACKGROUND: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks. OBJECTIVES: The aim of this study was to ...
    • Linear Growth Faltering Among HIV-Exposed Uninfected Children 

      Sudfeld, CR; Lei, Quanhong; Chinyanga, Y; Tumbare, E; Khan, N; Dapaah-Siakwan, F; Sebaka, A; Sibiya, J; van Widenfelt, E; Shapiro, RL; Makhema, Joseph Moeketsi; Fawzi, Wafaie W.; Powis, KM (Ovid Technologies (Wolters Kluwer Health), 2016)
      Background: HIV-exposed uninfected (HEU) children experience increased mortality compared wit their HIV-unexposed uninfected (HUU) peers. It is unclear whether HEU children are also at increased risk for undernutrition, a ...
    • Long-Range HIV Genotyping Using Viral RNA and Proviral DNA for Analysis of HIV Drug Resistance and HIV Clustering 

      Novitsky, Vladimir A.; Zahralban-Steele, Melissa; McLane, Mary Frances; Moyo, Sikhulile; van Widenfelt, Erik; Gaseitsiwe, Simani; Makhema, Joseph Moeketsi; Essex, Myron Elmer (American Society for Microbiology, 2015)
      The goal of the study was to improve the methodology of HIV genotyping for analysis of HIV drug resistance and HIV clustering. Using the protocol of Gall et al. (A. Gall, B. Ferns, C. Morris, S. Watson, M. Cotten, M. ...
    • Molecular characterisation of hepatitis B virus in HIV-1 subtype C infected patients in Botswana 

      Anderson, Motswedi; Gaseitsiwe, Simani; Moyo, Sikhulile; Wessels, Matthijs J. C.; Mohammed, Terence; Sebunya, Theresa K.; Powell, Eleanor A.; Makhema, Joseph; Blackard, Jason T.; Marlink, Richard; Essex, Max; Musonda, Rosemary M. (BioMed Central, 2015)
      Background: Hepatitis B virus (HBV) is a major global health problem especially in sub-Saharan Africa and in East Asia. Ten hepatitis B virus genotypes have been described that differ by geographic distribution, disease ...
    • P20-12. Heterogeneity of Gag Mutational Pathways in Primary HIV-1 Subtype C Infection 

      Lagakos, S; Kebaabetswe, L; Rossenkhan, R; Woldegabriel, E; van Widenfelt, E; Novitsky, Vladimir A.; Wang, Richard Yun; Margolin, Lauren; Baca, Jeannie; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Essex, Myron Elmer (BioMed Central, 2009)
      Poster presentation
    • Prevention of HIV-1 Infection with Early Antiretroviral Therapy 

      Cohen, Myron S.; Chen, Ying Q.; McCauley, Marybeth; Gamble, Theresa; Hosseinipour, Mina C.; Kumarasamy, Nagalingeswaran; Hakim, James G.; Kumwenda, Johnstone; Grinsztejn, Beatriz; Pilotto, Jose H.S.; Godbole, Sheela V.; Mehendale, Sanjay; Chariyalertsak, Suwat; Santos, Breno R.; Mayer, Kenneth Hugh; Hoffman, Irving F.; Eshleman, Susan H.; Piwowar-Manning, Estelle; Wang, Lei; Makhema, Joseph Moeketsi; Mills, Lisa A.; de Bruyn, Guy; Sanne, Ian; Eron, Joseph; Gallant, Joel; Havlir, Diane; Swindells, Susan; Ribaudo, Heather Jane; Elharrar, Vanessa; Burns, David; Taha, Taha E.; Nielsen-Saines, Karin; Celentano, David; Essex, Myron Elmer; Fleming, Thomas R. (New England Journal of Medicine (NEJM/MMS), 2011)
      BACKGROUND: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. METHODS: In nine countries, we enrolled 1763 couples ...
    • Regional Differences in Prevalence of HIV-1 Discordance in Africa and Enrollment of HIV-1 Discordant Couples into an HIV-1 Prevention Trial 

      Lingappa, Jairam R.; Lambdin, Barrot; Bukusi, Elizabeth Ann; Ngure, Kenneth; Kavuma, Linda; Inambao, Mubiana; Kanweka, William; Allen, Susan; Kiarie, James N.; Were, Edwin; Manongi, Rachel; Coetzee, David; de Bruyn, Guy; Delany-Moretlwe, Sinead; Magaret, Amalia; Mugo, Nelly; Mujugira, Andrew; Ndase, Patrick; Celum, Connie; Makhema, Joseph Moeketsi (Public Library of Science, 2008)
      Background: Most HIV-1 transmission in Africa occurs among HIV-1-discordant couples (one partner HIV-1 infected and one uninfected) who are unaware of their discordant HIV-1 serostatus. Given the high HIV-1 incidence among ...
    • Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine 

      Lockman, Shahin; Shapiro, Roger L.; Smeaton, Laura Marie; Wester, Carolyn; Thior, Ibou; Stevens, Lisa; Chand, Fatima; Makhema, Joseph Moeketsi; Moffat, Claire; Asmelash, Aida; Ndase, Patrick; van Widenfelt, Peter Arimim Eri; Mazhani, Loeto; Novitsky, Vladimir A.; Lagakos, Stephen; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2007)
      BACKGROUND: A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants. METHODS: ...
    • Short Communication: Effect of Short-Course Antenatal Zidovudine and Single-Dose Nevirapine on the BED Capture Enzyme Immunoassay Levels in HIV Type 1 Subtype C Infection 

      Wang, Rui; Weng, Jia; Moyo, Sikhulile; Pain, Debanjan; Barr, Christopher D.; Maruapula, Dorcas; Mongwato, Dineo; Makhema, Joseph Moeketsi; Novitsky, Vladimir A.; Essex, Myron Elmer (Mary Ann Liebert Inc., 2013)
      Cross-sectional prevalence studies based on immunoassays that discriminate between recent and long-term infections, such as the BED assay, have been widely used to estimate HIV incidence. However, individuals receiving ...
    • Slow CD4+ T-Cell Recovery in Human Immunodeficiency Virus/Hepatitis B Virus-Coinfected Patients Initiating Truvada-Based Combination Antiretroviral Therapy in Botswana 

      Anderson, Motswedi; Gaseitsiwe, Simani; Moyo, Sikhulile; Thami, Kerapetse P.; Mohammed, Terence; Setlhare, Ditiro; Sebunya, Theresa K.; Powell, Eleanor A.; Makhema, Joseph; Blackard, Jason T.; Marlink, Richard; Essex, Max; Musonda, Rosemary M. (Oxford University Press, 2016)
      Background. Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection has emerged as an important cause of morbidity and mortality. We determined the response to Truvada-based first-line combination ...