Browsing by Author "Handy, Diane"
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Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification
Balderman, Joshua A. F.; Lee, Hae‐Young; Mahoney, Christopher E.; Handy, Diane Elizabeth; White, Kevin; Annis, Sofia; Lebeche, Djamel; Hajjar, Roger J.; Loscalzo, Joseph; Leopold, Jane Anne (Blackwell Publishing Ltd, 2012)Background: Vascular calcification resembles bone formation and involves vascular smooth muscle cell (SMC) transition to an osteoblast‐like phenotype to express Runx2, a master osteoblast transcription factor. One possible ... -
Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)
Loscalzo, Joseph; Handy, Diane E. (University of Chicago Press, 2014)Abstract Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular ... -
Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose
Zhang, Zhaoyun; Yang, Zhihong; Zhu, Bo; Hu, Ji; Liew, Chong-Wee; Leopold, Jane Anne; Handy, Diane Elizabeth; Loscalzo, Joseph; Stanton, Robert Carl; Zhang, Ying-Yi (Public Library of Science, 2012)Previous studies have shown that high glucose increases reactive oxygen species (ROS) in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Accumulation of ROS is due to dysregulated redox ... -
Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case
Garmaroudi, Farshid S.; Handy, Diane E.; Liu, Yang-Yu; Loscalzo, Joseph (Public Library of Science, 2016)Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic ...