Now showing items 1-15 of 15

    • Aseptic Meningitis with Craniopharyngioma Resection: Consideration after Endoscopic Surgery 

      Chen, Jenny X.; Alkire, Blake C.; Lam, Allen C.; Curry, William T.; Holbrook, Eric H. (Georg Thieme Verlag KG, 2016)
      Objectives: While bacterial meningitis is a concerning complication after endoscopic skull base surgery, the diagnosis can be made without consideration for aseptic meningitis. This article aims to (1) present a patient ...
    • Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression 

      Sullivan, James P; Nahed, Brian Vala; Madden, M. W.; Oliveira, S. M.; Springer, S.; Bhere, Deepak; Chi, A. S.; Wakimoto, Hiroaki; Rothenberg, S. M.; Sequist, Lecia VanDam; Kapur, R.; Shah, Khalid A.; Iafrate, Anthony John; Curry, William Thomas; Loeffler, Jay Steven; Batchelor, Tracy Todd; Louis, David N.; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel Arie (American Association for Cancer Research (AACR), 2014)
      Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion and angiogenic recruitment, yet metastatic dissemination is extremely rare. Here, we adapted a microfluidic device to deplete hematopoietic ...
    • Clinical features of brain metastasis from salivary gland tumors 

      Venteicher, Andrew S; Walcott, Brian; Sheth, Sameer A.; Snuderl, Matija; Patel, Anoop Premswaroop; Curry, William Thomas; Nahed, Brian Vala (Elsevier BV, 2013)
      Salivary gland tumors comprise a group of 24 tumor subtypes with a wide range of clinical behaviors and propensities for metastasis. Several prognostic factors have been identified that help predict the development of ...
    • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq 

      Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine; Yizhak, Keren; Neftel, Cyril Ralf Alexander; Filbin, Mariella Gruber; Hovestadt, Volker; Escalante, Leah; Shaw, McKenzie; Rodman, Christopher Jiahn-Leh; Gillespie, Shawn; Dionne, Danielle; Luo, Christina; Ravichandran, Hiranmayi; Mylvaganam, Ravindra; Mount, Christopher; Onozato, Maristela Lika; Nahed, Brian Vala; Wakimoto, Hiroaki; Curry, William Thomas; Iafrate, Anthony John; Rivera, Miguel Nicolas; Frosch, Matthew P.; Golub, Todd Robert; Brastianos, Priscilla Kalliope; Getz, Gad A; Patel, Anoop Premswaroop; Monje, Michelle; Cahill, Daniel P.; Rozenblatt-Rosen, Orit; Louis, David N.; Bernstein, Bradley E.; Regev, Aviv; Suvà, Mario (American Association for the Advancement of Science (AAAS), 2017)
    • Delayed Endovascular Coil Extrusion following Internal Carotid Artery Embolization 

      Dedmon, Matthew; Meier, Josh; Chambers, Kyle; Remenschneider, Aaron; Mehta, Brijesh; Lin, Derrick; Yoo, Albert J.; Curry, William; Gray, Stacey (Georg Thieme Verlag KG, 2014)
      Internal carotid artery injury is a rare and devastating complication of endoscopic sinus and skull base surgery that has an associated mortality rate of 15%. This case describes a patient who developed massive epistaxis ...
    • Immediate and Delayed Complications Following Endoscopic Skull Base Surgery 

      Naunheim, Matthew Roberts; Sedaghat, Ahmad; Lin, Derrick T.; Bleier, Benjamin; Holbrook, Eric Hans; Curry, William Thomas; Gray, Stacey Tutt (Thieme Publishing Group, 2015)
      Objectives To characterize the temporal distribution and resolution rate of postoperative complications from endoscopic skull base surgery. Design Retrospective review of patients undergoing endoscopic resection of ...
    • Immunohistochemical characterization of human olfactory tissue 

      Holbrook, Eric Hans; Wu, Enming; Curry, William Thomas; Lin, Derrick T.; Schwob, James E. (Wiley-Blackwell, 2011)
      Objectives/Hypothesis The pathophysiology underlying human olfactory disorders is poorly understood because biopsying the olfactory epithelium (OE) can be unrepresentative and extensive immunohistochemical analysis is ...
    • Links Between Annual, Milankovitch and Continuum Temperature Variability 

      Huybers, Peter John; Curry, William Thomas (Nature Publishing Group, 2006)
      Climate variability exists at all timescales—and climatic processes are intimately coupled, so that understanding variability at any one timescale requires some understanding of the whole. Records of the Earth's surface ...
    • Management of a Long-Standing Organic Intracranial Foreign Body 

      Wieland, Aaron; Curry, William Thomas; Durand, Marlene Leslie; Holbrook, Eric Hans (Thieme Publishing Group, 2010)
      Organic foreign bodies of the skull base are an uncommon problem with the potential for serious morbidity that present complicated treatment dilemmas best managed by a multidisciplinary approach. A 58-year-old male presented ...
    • Postoperative Intensive Care Unit Requirements After Elective Craniotomy 

      Hanak, Brian W.; Walcott, Brian; Nahed, Brian Vala; Muzikansky, Alona; Mian, Matthew Kamal; Kimberly, William Taylor; Curry, William Thomas (Elsevier BV, 2014)
      Objective: Commonly, patients undergoing craniotomy are admitted to an intensive care setting post-operatively to allow for close monitoring. We aim to determine the frequency with which patients who have undergone elective ...
    • Rapid Intraoperative Molecular Characterization of Glioma 

      Shankar, Ganesh Mani; Francis, Joshua M.; Rinne, Mikael Lee; Ramkissoon, Shakti; Huang, Franklin W; Venteicher, Andrew S; Akama-Garren, Elliot H.; Kang, Yun Jee; Lelic, Nina; Kim, James C.; Brown, Loreal E.; Charbonneau, Sarah K; Golby, Alexandra Jacqueline; Sekhar Pedamallu, Chandra; Hoang, Mai P; Sullivan, Ryan Joseph; Cherniack, Andrew D.; Garraway, Levi Alexander; Stemmer-Rachamimov, Anat; Reardon, David Allen; Wen, Patrick Yung Chih; Brastianos, Priscilla Kalliope; Curry, William Thomas; Barker, Frederick George; Hahn, William Chun; Nahed, Brian Vala; Ligon, Keith Lloyd; Louis, David N.; Cahill, Daniel P.; Meyerson, Matthew Langer (American Medical Association (AMA), 2015)
      IMPORTANCE: Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection. Establishing the intraoperative diagnosis by histologic analysis ...
    • A Rare Finding of Schwannoma of the Vidian Canal: A Case Report 

      Yamasaki, Alisa; Sedaghat, Ahmad R.; Lin, Giant C.; Curry, William T.; Shih, Helen A.; Gray, Stacey T. (Georg Thieme Verlag KG, 2015)
      Background: Schwannomas of the vidian canal are an extremely rare type of intracranial tumor that can have variable clinical presentations including headache, facial pain, facial muscle paralysis, decreased lacrimation, ...
    • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells 

      Suva, Mario Luca; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel David; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Rivera, Miguel Nicolas; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David N.; Bernstein, Bradley E. (Elsevier BV, 2014)
      Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies ...
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma 

      Patel, Anoop Premswaroop; Tirosh, I.; Trombetta, J. J.; Shalek, Alexander Kann; Gillespie, S. M.; Wakimoto, Hiroaki; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Louis, David N.; Rozenblatt-Rosen, O.; Suva, Mario Luca; Regev, A.; Bernstein, Bradley E. (American Association for the Advancement of Science (AAAS), 2014)
      Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single cell RNA-seq to ...
    • Sporadic hemangioblastomas are characterized by cryptic VHL inactivation 

      Shankar, Ganesh Mani; Taylor-Weiner, Amaro; Lelic, Nina; Jones, Robert T; Kim, James C; Francis, Joshua M; Abedalthagafi, Malak S; Borges, Lawrence Francis; Coumans, Jean-Valery C E; Curry, William Thomas; Nahed, Brian Vala; Shin, John H; Paek, Sun Ha; Park, Sung-Hye; Stewart, Chip; Lawrence, Michael S; Cibulskis, Kristian; Thorner, Aaron R; Van Hummelen, Paul; Stemmer-Rachamimov, Anat; Batchelor, Tracy Todd; Carter, Scott Lambert; Hoang, Mai P; Santagata, Sandro; Louis, David N.; Barker, Frederick George; Meyerson, Matthew Langer; Getz, Gad A; Brastianos, Priscilla Kalliope; Cahill, Daniel P. (Springer Nature, 2014)
      Hemangioblastomas consist of 10-20% neoplastic “stromal” cells within a vascular tumor cell mass of reactive pericytes, endothelium and lymphocytes. Familial cases of central nervous system hemangioblastoma uniformly result ...