Now showing items 1-20 of 54

    • ABO blood group and incidence of epithelial ovarian cancer 

      Gates, Margaret A.; Wolpin, Brian M.; Cramer, Daniel William; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate (Wiley-Blackwell, 2010)
      Previous studies have observed an association between ABO blood group and risk of certain malignancies, including ovarian cancer; however, no prospective studies of the association with ovarian cancer risk are available. ...
    • Anti-MUC1 Antibodies and Ovarian Cancer Risk: Prospective Data from the Nurses' Health Studies 

      Pinheiro, S. P.; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate; Rosner, Bernard Alfred; McKolanis, J. R.; Finn, O. J.; Cramer, Daniel William (American Association for Cancer Research (AACR), 2010)
      The surface epithelial glycoprotein MUC1 becomes overexpressed and hypoglycosylated in adenocarcinomas; similar changes occur during nonmalignant inflammatory events. Antibodies developed against tumor-like MUC1 in response ...
    • Association between Cutaneous Nevi and Breast Cancer in the Nurses' Health Study: A Prospective Cohort Study 

      Zhang, Mingfeng; Zhang, Xuehong; Qureshi, Abrar A.; Eliassen, A. Heather; Hankinson, Susan E.; Han, Jiali (Public Library of Science, 2014)
      Background: Cutaneous nevi are suggested to be hormone-related. We hypothesized that the number of cutaneous nevi might be a phenotypic marker of plasma hormone levels and predict subsequent breast cancer risk. Methods and ...
    • The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers 

      Ramin, Cody A; Massa, Jennifer; Wegrzyn, Lani R; Brown, Susan B; Pierre-Paul, Jeffrey; Devore, Elizabeth E; Hankinson, Susan E; Schernhammer, Eva S (BioMed Central, 2015)
      Background: Adult body mass index (BMI) has been associated with urinary melatonin levels in humans; however, whether earlier-life body size is associated with melatonin, particularly among night shift workers, remains ...
    • Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome 

      Shurubor, Yevgeniya I; Matson, Wayne R; Willett, Walter C.; Hankinson, Susan Elizabeth; Kristal, Bruce S. (BioMed Central, 2007)
      Background: Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations ...
    • Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations 

      Gates, Margaret A.; Tworoger, Shelley Slate; Terry, Kathryn Lynne; De Vivo, Immaculata; Hunter, David J.; Hankinson, Susan Elizabeth; Cramer, Daniel William (Wiley-Blackwell, 2009)
      Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1, and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer ...
    • Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer 

      Kotsopoulos, Joanne; Vitonis, Allison F.; Terry, Kathryn Lynne; De Vivo, Immaculata; Cramer, Daniel William; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate (Springer Science + Business Media, 2008)
      We evaluated whether genetic variability, as well as menopausal status, modify the association between coffee intake and risk of ovarian cancer. Risk factor information and biologic specimens from three large epidemiological ...
    • The Combined Influence of Multiple Sex and Growth Hormones on Risk of Postmenopausal Breast Cancer: A Nested Case-control Study 

      Tworoger, Shelley Slate; Rosner, Bernard Alfred; Willett, Walter C.; Hankinson, Susan Elizabeth (BioMed Central, 2011)
      Introduction: Sex and growth hormones are positively associated with postmenopausal breast cancer risk. However, few studies have evaluated the influence of multiple hormones simultaneously. Methods: We considered the roles ...
    • Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study 

      Tamimi, Rulla May; Hankinson, Susan Elizabeth; Spiegelman, Donna Lynn; Kraft, Peter; Colditz, Graham A.; Hunter, David J. (BioMed Central, 2004)
      Introduction: The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for ...
    • Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk 

      Terry, Kathryn Lynne; Tworoger, Shelley Slate; Gates, M. A.; Cramer, Daniel William; Hankinson, Susan Elizabeth (Oxford University Press (OUP), 2009)
      Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for ...
    • Common germline polymorphisms associated with breast cancer-specific survival 

      Pirie, Ailith; Guo, Qi; Kraft, Peter; Canisius, Sander; Eccles, Diana M; Rahman, Nazneen; Nevanlinna, Heli; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Dunning, Alison M; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Dieter; Weltens, Caroline; Leunen, Karin; van Ongeval, Chantal; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A; Olsen, Janet E; Hallberg, Emily; Vachon, Celine; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Cornelissen, Sten; Haiman, Christopher A; Henderson, Brian E; Schumacher, Frederick; Le Marchand, Loic; Hopper, John L; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C; Cross, Simon S; Reed, Malcolm WR; Giles, Graham G; Milne, Roger L; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J; Hollestelle, Antoinette; Martens, John WM; van den Ouweland, Ans MW; Marme, Federick; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Brenner, Hermann; Butterbach, Katja; Holleczek, Bernd; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Devilee, Peter; Tollenaar, Robert AEM; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Ficarazzi, Filomena; Beckmann, Matthias W; Hein, Alexander; Ekici, Arif B; Balleine, Rosemary; Phillips, Kelly-Anne; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Siljie; Evans, D Gareth; Abraham, Jean; Earl, Helena; Poole, Christopher J; Hiller, Louise; Dunn, Janet A; Bowden, Sarah; Yang, Rose; Campa, Daniele; Diver, W Ryan; Gapstur, Susan M; Gaudet, Mia M; Hankinson, Susan; Hoover, Robert N; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J; Lindstrom, Sara; Garcia-Closas, Montserrat; Couch, Fergus J; Chenevix-Trench, Georgia; Mannermaa, Arto; Andrulis, Irene L; Hall, Per; Chang-Claude, Jenny; Easton, Douglas F; Bojesen, Stig E; Cox, Angela; Fasching, Peter A; Pharoah, Paul DP; Schmidt, Marjanka K (BioMed Central, 2015)
      Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was ...
    • Consortium analysis of 7 candidate SNPs for ovarian cancer 

      Ramus, Susan J.; Vierkant, Robert A.; Johnatty, Sharon E.; Pike, Malcolm C.; Van Den Berg, David J.; Wu, Anna H.; Pearce, Celeste Leigh; Menon, Usha; Gentry-Maharaj, Aleksandra; Gayther, Simon A.; DiCioccio, Richard A.; McGuire, Valerie; Whittemore, Alice S.; Song, Honglin; Easton, Douglas F.; Pharoah, Paul D.P.; Garcia-Closas, Montserrat; Chanock, Stephen; Lissowska, Jolanta; Brinton, Louise; Terry, Kathryn Lynne; Cramer, Daniel William; Tworoger, Shelley Slate; Hankinson, Susan Elizabeth; Berchuck, Andrew; Moorman, Patricia G.; Schildkraut, Joellen M.; Cunningham, Julie M.; Liebow, Mark; Kjaer, Susanne Krüger; Hogdall, Estrid; Hogdall, Claus; Blaakaer, Jan; Ness, Roberta B.; Moysich, Kirsten B.; Edwards, Robert P.; Carney, Michael E.; Lurie, Galina; Goodman, Marc T.; Wang-Gohrke, Shan; Kropp, Silke; Chang-Claude, Jenny; Webb, Penelope M.; Chen, Xiaoqing; Beesley, Jonathan; Chenevix-Trench, Georgia; Goode, Ellen L. (Wiley-Blackwell, 2008)
      The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer ...
    • Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk 

      Merritt, Melissa A.; Kotsopoulos, Joanne; Cramer, Daniel William; Hankinson, Susan Elizabeth; Terry, Kathryn Lynne; Tworoger, Shelley Slate (Elsevier BV, 2012)
      Objective To investigate whether Galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk and to determine if this association was modified by lactose ...
    • Endogenous Levels of Circulating Androgens and Risk of Crohn's Disease and Ulcerative Colitis Among Women: A Nested Case–Control Study from the Nurses' Health Study Cohorts 

      Khalili, Hamed; Ananthakrishnan, Ashwin N.; Konijeti, Gauree G.; Higuchi, Leslie M.; Fuchs, Charles S.; Richter, James M.; Tworoger, Shelley S.; Hankinson, Susan E.; Chan, Andrew T. (Lippincott Williams & Wilkins, 2015)
      Background: Androgens, which are known to be altered by exogenous hormone use, have recently been linked to alterations of the gut microbiome and mucosal immune function. No study has evaluated the association between ...
    • Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot” 

      Johnatty, Sharon E.; Beesley, Jonathan; Chen, Xiaoqing; Macgregor, Stuart; Duffy, David L.; Spurdle, Amanda B.; deFazio, Anna; Gava, Natalie; Webb, Penelope M.; Rossing, Mary Anne; Doherty, Jennifer Anne; Goodman, Marc T.; Lurie, Galina; Wilkens, Lynne R.; Ness, Roberta B.; Moysich, Kirsten B.; Chang-Claude, Jenny; Wang-Gohrke, Shan; Garcia-Closas, Montserrat; Yang, Hannah; Lissowska, Jolanta; Chanock, Stephen J.; Pharoah, Paul D.; Song, Honglin; Whitemore, Alice S.; Pearce, Celeste L.; Stram, Daniel O.; Wu, Anna H.; Pike, Malcolm C.; Gayther, Simon A.; Ramus, Susan J.; Menon, Usha; Gentry-Maharaj, Aleksandra; Anton-Culver, Hoda; Ziogas, Argyrios; Hogdall, Estrid; Kjaer, Susanne K.; Hogdall, Claus; Berchuck, Andrew; Schildkraut, Joellen M.; Iversen, Edwin S.; Moorman, Patricia G.; Phelan, Catherine M.; Sellers, Thomas A.; Cunningham, Julie M.; Vierkant, Robert A.; Rider, David N.; Goode, Ellen L.; Haviv, Izhak; Chenevix-Trench, Georgia; Thompson, Pamela J.; Cramer, Daniel William; Terry, Kathryn Lynne; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate (Public Library of Science, 2010)
      We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach ...
    • Exome-Wide Association Study of Endometrial Cancer in a Multiethnic Population 

      Chen, Maxine M.; Crous-Bou, Marta; Setiawan, Veronica W.; Prescott, Jennifer; Olson, Sara H.; Wentzensen, Nicolas; Black, Amanda; Brinton, Louise; Chen, Chu; Chen, Constance; Cook, Linda S.; Doherty, Jennifer; Friedenreich, Christine M.; Hankinson, Susan E.; Hartge, Patricia; Henderson, Brian E.; Hunter, David J.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Lu, Lingeng; Orlow, Irene; Petruzella, Stacey; Polidoro, Silvia; Pooler, Loreall; Rebbeck, Timothy R.; Risch, Harvey; Sacerdote, Carlotta; Schumacher, Frederick; Sheng, Xin; Shu, Xiao-ou; Weiss, Noel S.; Xia, Lucy; Van Den Berg, David; Yang, Hannah P.; Yu, Herbert; Chanock, Stephen; Haiman, Christopher; Kraft, Peter; De Vivo, Immaculata (Public Library of Science, 2014)
      Endometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. ...
    • Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome 

      Machiela, Mitchell J.; Zhou, Weiyin; Karlins, Eric; Sampson, Joshua N.; Freedman, Neal D.; Yang, Qi; Hicks, Belynda; Dagnall, Casey; Hautman, Christopher; Jacobs, Kevin B.; Abnet, Christian C.; Aldrich, Melinda C.; Amos, Christopher; Amundadottir, Laufey T.; Arslan, Alan A.; Beane-Freeman, Laura E.; Berndt, Sonja I.; Black, Amanda; Blot, William J.; Bock, Cathryn H.; Bracci, Paige M.; Brinton, Louise A.; Bueno-de-Mesquita, H Bas; Burdett, Laurie; Buring, Julie E.; Butler, Mary A.; Canzian, Federico; Carreón, Tania; Chaffee, Kari G.; Chang, I-Shou; Chatterjee, Nilanjan; Chen, Chu; Chen, Constance; Chen, Kexin; Chung, Charles C.; Cook, Linda S.; Crous Bou, Marta; Cullen, Michael; Davis, Faith G.; De Vivo, Immaculata; Ding, Ti; Doherty, Jennifer; Duell, Eric J.; Epstein, Caroline G.; Fan, Jin-Hu; Figueroa, Jonine D.; Fraumeni, Joseph F.; Friedenreich, Christine M.; Fuchs, Charles S.; Gallinger, Steven; Gao, Yu-Tang; Gapstur, Susan M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Gaziano, J. Michael; Giles, Graham G.; Gillanders, Elizabeth M.; Giovannucci, Edward L.; Goldin, Lynn; Goldstein, Alisa M.; Haiman, Christopher A.; Hallmans, Goran; Hankinson, Susan E.; Harris, Curtis C.; Henriksson, Roger; Holly, Elizabeth A.; Hong, Yun-Chul; Hoover, Robert N.; Hsiung, Chao A.; Hu, Nan; Hu, Wei; Hunter, David J.; Hutchinson, Amy; Jenab, Mazda; Johansen, Christoffer; Khaw, Kay-Tee; Kim, Hee Nam; Kim, Yeul Hong; Kim, Young Tae; Klein, Alison P.; Klein, Robert; Koh, Woon-Puay; Kolonel, Laurence N.; Kooperberg, Charles; Kraft, Peter; Krogh, Vittorio; Kurtz, Robert C.; LaCroix, Andrea; Lan, Qing; Landi, Maria Teresa; Marchand, Loic Le; Li, Donghui; Liang, Xiaolin; Liao, Linda M.; Lin, Dongxin; Liu, Jianjun; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Malats, Nuria; Matsuo, Keitaro; McNeill, Lorna H.; McWilliams, Robert R.; Melin, Beatrice S.; Mirabello, Lisa; Moore, Lee; Olson, Sara H.; Orlow, Irene; Park, Jae Yong; Patiño-Garcia, Ana; Peplonska, Beata; Peters, Ulrike; Petersen, Gloria M.; Pooler, Loreall; Prescott, Jennifer; Prokunina-Olsson, Ludmila; Purdue, Mark P.; Qiao, You-Lin; Rajaraman, Preetha; Real, Francisco X.; Riboli, Elio; Risch, Harvey A.; Rodriguez-Santiago, Benjamin; Ruder, Avima M.; Savage, Sharon A.; Schumacher, Fredrick; Schwartz, Ann G.; Schwartz, Kendra L.; Seow, Adeline; Wendy Setiawan, Veronica; Severi, Gianluca; Shen, Hongbing; Sheng, Xin; Shin, Min-Ho; Shu, Xiao-Ou; Silverman, Debra T.; Spitz, Margaret R.; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Stram, Daniel; Tang, Ze-Zhong; Taylor, Philip R.; Teras, Lauren R.; Tobias, Geoffrey S.; Van Den Berg, David; Visvanathan, Kala; Wacholder, Sholom; Wang, Jiu-Cun; Wang, Zhaoming; Wentzensen, Nicolas; Wheeler, William; White, Emily; Wiencke, John K.; Wolpin, Brian M.; Wong, Maria Pik; Wu, Chen; Wu, Tangchun; Wu, Xifeng; Wu, Yi-Long; Wunder, Jay S.; Xia, Lucy; Yang, Hannah P.; Yang, Pan-Chyr; Yu, Kai; Zanetti, Krista A.; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Zhou, Baosen; Ziegler, Regina G.; Perez-Jurado, Luis A.; Caporaso, Neil E.; Rothman, Nathaniel; Tucker, Margaret; Dean, Michael C.; Yeager, Meredith; Chanock, Stephen J. (Nature Publishing Group, 2016)
      To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected ...
    • Flavonoid intake and ovarian cancer risk in a population-based case-control study 

      Gates, Margaret A.; Vitonis, Allison F.; Tworoger, Shelley Slate; Rosner, Bernard Alfred; Titus-Ernstoff, Linda; Hankinson, Susan Elizabeth; Cramer, Daniel William (Wiley-Blackwell, 2009)
      Several recent studies have evaluated the association between dietary flavonoid intake and ovarian cancer risk, and all reported significant or suggestive inverse associations with certain flavonoids or flavonoid subclasses; ...
    • Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study 

      Du, Mengmeng; Prescott, Jennifer; Cornelis, Marilyn; Hankinson, Susan Elizabeth; Giovannucci, Edward L.; Kraft, Phillip L.; De Vivo, Immaculata (Public Library of Science, 2013)
      Background: Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. ...
    • Genetic risk variants associated with in situ breast cancer 

      Campa, Daniele; Barrdahl, Myrto; Gaudet, Mia M.; Black, Amanda; Chanock, Stephen J.; Diver, W. Ryan; Gapstur, Susan M.; Haiman, Christopher; Hankinson, Susan; Hazra, Aditi; Henderson, Brian; Hoover, Robert N.; Hunter, David J.; Joshi, Amit D.; Kraft, Peter; Le Marchand, Loic; Lindström, Sara; Willett, Walter; Travis, Ruth C.; Amiano, Pilar; Siddiq, Afshan; Trichopoulos, Dimitrios; Sund, Malin; Tjønneland, Anne; Weiderpass, Elisabete; Peeters, Petra H.; Panico, Salvatore; Dossus, Laure; Ziegler, Regina G.; Canzian, Federico; Kaaks, Rudolf (BioMed Central, 2015)
      Introduction: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered ...