Browsing by Author "Chun, Eunyoung"
Now showing items 1-3 of 3
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AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals
Jung, E; Baik, K-H; Shim, J-H; Lee, K-Y; Kim, S.Y.; Jeong, S.; Chang, M. H.; Kim, S. A.; Chun, Eunyoung (Nature Publishing Group, 2012)Although previous studies have proposed plausible mechanisms of the activation of transforming growth factor-β-activated kinase 1 (TAK1) in inflammatory signals, including Toll-like receptors (TLRs), its activating kinase ... -
Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6
Min, Yoon; Wi, Sae Mi; Kang, Jung-Ah; Yang, Taewoo; Park, Chul-Seung; Park, Sung-Gyoo; Chung, Sungkwon; Shim, Jae-Hyuck; Chun, Eunyoung; Lee, Ki-Young (Nature Publishing Group, 2016)Cereblon (CRBN) is a substrate receptor protein for the CRL4A E3 ubiquitin ligase complex. In this study, we report on a new regulatory role of CRBN in TLR4 signaling. CRBN overexpression leads to suppression of NF-κB ... -
Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling
Mi Wi, Sae; Park, Jeongho; Shim, Jae-Hyuck; Chun, Eunyoung; Lee, Ki-Young (The American Society for Cell Biology, 2015)Recent evidence shows that evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) interacts with tumor necrosis factor receptor–associated factor 6 (TRAF6), is ubiquitinated, and contributes to bactericidal ...