Browsing by Author "Ku, Manching"
Now showing items 1-3 of 3
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GC-rich sequence elements recruit PRC2 in mammalian ES cells
Mendenhall, Eric M; Koche, Richard Patrick; Truong, Thanh; Zhou, Vicky Weijie; Issac, Biju; Chi, Andrew S.; Ku, Manching; Bernstein, Bradley E. (Public Library of Science, 2010)Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements ... -
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
Rheinbay, Esther; Endoh, Mitsuhiro; Mikkelsen, Tarjei S.; Nusbaum, Chad; Xie, Xiaohui; Adli, Mazhar; Kasif, Simon; Ptaszek, Leon M.; Koseki, Haruhiko; van Steensel, Bas; Ku, Manching; Koche, Richard Patrick; Mendenhall, Eric M; Presser, Aviva; Chi, Andrew S.; Cowan, Chad A.; Lander, Eric Steven; Bernstein, Bradley E. (Public Library of Science, 2008)In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 ... -
H2A.Z Landscapes and Dual Modifications in Pluripotent and Multipotent Stem Cells Underlie Complex Genome Regulatory Functions
Ku, Manching; Jaffe, Jacob D; Koche, Richard P; Rheinbay, Esther; Endoh, Mitsuhiro; Koseki, Haruhiko; Carr, Steven A; Bernstein, Bradley E (BioMed Central, 2012)Background: The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. ...