Browsing by Author "Walter, Stefan"

Now showing items 1-5 of 5

    • Changes in Depressive Symptoms and Incidence of First Stroke Among Middle-Aged and Older US Adults 

      Gilsanz, Paola; Walter, Stefan; Tchetgen, Eric; Patton, Kristen; Moon, James; Capistrant, Benjamin; Marden, Jessica Rachel; Kubzansky, Laura D; Kawachi, Ichiro; Glymour, Maria Lee (Wiley Blackwell, 2015)
      BACKGROUND: Although research has demonstrated that depressive symptoms predict stroke incidence, depressive symptoms are dynamic. It is unclear whether stroke risk persists if depressive symptoms remit. METHODS AND ...

    • Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling 

      Ho, Jennifer E.; Chen, Wei-Yu; Chen, Ming-Huei; Larson, Martin G.; McCabe, Elizabeth L.; Cheng, Susan; Ghorbani, Anahita; Coglianese, Erin; Emilsson, Valur; Johnson, Andrew D.; Walter, Stefan; Franceschini, Nora; O'Donnell, Christopher Joseph; Dehghan, Abbas; Lu, Chen; Levy, Daniel; Newton-Cheh, Christopher Holmes; Lin, Honghuang; Felix, Janine F.; Schreiter, Eric R.; Vasan, Ramachandran S.; Januzzi, James Louis; Lee, Richard Theodore; Wang, Thomas (American Society for Clinical Investigation, 2013)
      The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response ...

    • Genome-wide polygenic scoring for a 14-year long-term average depression phenotype 

      Chang, Shun-Chiao; Glymour, M Maria; Walter, Stefan; Liang, Liming; Koenen, Karestan C; Tchetgen, Eric J; Cornelis, Marilyn C; Kawachi, Ichiro; Rimm, Eric; Kubzansky, Laura D (Wiley Periodicals, Inc., 2014)
      Background: Despite moderate heritability estimates for depression-related phenotypes, few robust genetic predictors have been identified. Potential explanations for this discrepancy include the use of phenotypic measures ...

    • Performance of Polygenic Scores for Predicting Phobic Anxiety 

      Walter, Stefan; Glymour, M. Maria; Koenen, Karestan; Liang, Liming; Tchetgen Tchetgen, Eric J.; Cornelis, Marilyn; Chang, Shun-Chiao; Rimm, Eric; Kawachi, Ichiro; Kubzansky, Laura D. (Public Library of Science, 2013)
      Context Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization. To date, no causal genetic ...

    • Social Integration and Reduced Risk of Coronary Heart Disease in WomenNovelty and Significance 

      Chang, Shun-Chiao; Glymour, Maria Lee; Cornelis, Marilyn; Walter, Stefan; Rimm, Eric Bruce; Tchetgen Tchetgen, Eric Joel; Kawachi, Ichiro; Kubzansky, Laura Diane (Ovid Technologies (Wolters Kluwer Health), 2017)
      RATIONALE: Higher social integration is associated with lower cardiovascular mortality; however, whether it is associated with incident coronary heart disease (CHD), especially in women, and whether associations differ ...