Now showing items 1-6 of 6

• #### Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals ﻿

(Public Library of Science, 2011)
Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation ...
• #### Fine Mapping the $KLK3$ Locus on Chromosome 19q13.33 Associated With Prostate Cancer Susceptibility and PSA Levels ﻿

(Springer-Verlag, 2011)
Measurements of serum prostate-speciﬁc antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein ($KLK3$) have been ...
• #### A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium ﻿

(Public Library of Science, 2011)
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation ...
• #### Modern mammography screening and breast cancer mortality: population study ﻿

(BMJ Publishing Group Ltd., 2014)
Objective: To evaluate the effectiveness of contemporary mammography screening using individual information about screening history and breast cancer mortality from public screening programmes. Design: Prospective cohort ...
• #### Pre-eclampsia, Soluble fms-like Tyrosine Kinase 1, and the Risk of Reduced Thyroid Function: Nested Case-Control and Population Based Study ﻿

(BMJ Publishing Group, 2009)
Objective: To determine if pre-eclampsia is associated with reduced thyroid function during and after pregnancy. Design: Nested case-control study during pregnancy and population based follow-up study after pregnancy. ...
• #### Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer ﻿

(Springer Nature, 2014)
We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and ...