Now showing items 1-6 of 6

    • Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals 

      Chan, Yingleong; Holmen, Oddgeir L.; Havulinna, Aki S.; Skorpen, Frank; Kvaløy, Kirsti; Silander, Kaisa; Nguyen, Thutrang T.; Willer, Cristen; Boehnke, Michael; Perola, Markus; Palotie, Aarno; Salomaa, Veikko; Hveem, Kristian; Frayling, Timothy M.; Weedon, Michael N.; Dauber, Andrew Nahum; Vatten, Lars Johan; Hirschhorn, Joel Naom (Public Library of Science, 2011)
      Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation ...
    • Fine Mapping the \(KLK3\) Locus on Chromosome 19q13.33 Associated With Prostate Cancer Susceptibility and PSA Levels 

      Parikh, Hemang; Wang, Zhaoming; Pettigrew, Kerry A.; Jia, Jinping; Daugherty, Sarah; Yeager, Meredith; Jacobs, Kevin B.; Hutchinson, Amy; Burdett, Laura; Cullen, Michael; Qi, Liqun; Boland, Joseph; Collins, Irene; Albert, Thomas J.; Hveem, Kristian; Cancel-Tassin, Geraldine; Cussenot, Olivier; Valeri, Antoine; Virtamo, Jarmo; Thun, Michael J.; Feigelson, Heather Spencer; Diver, W. Ryan; Chatterjee, Nilanjan; Thomas, Gilles; Albanes, Demetrius; Chanock, Stephen J.; Hoover, Robert; Hayes, Richard B.; Berndt, Sonja I.; Sampson, Joshua; Amundadottir, Laufey; Vatten, Lars Johan; Hunter, David J.; Njølstad, Inger (Springer-Verlag, 2011)
      Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (\(KLK3\)) have been ...
    • A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium 

      McKay, James D.; Truong, Therese; Gaborieau, Valerie; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, Graham; Zaridze, David; Shangina, Oxana; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Bucur, Alexandru; Bencko, Vladimir; Holcatova, Ivana; Janout, Vladimir; Foretova, Lenka; Benhamou, Simone; Bouchardy, Christine; Ahrens, Wolfgang; Merletti, Franco; Richiardi, Lorenzo; Talamini, Renato; Barzan, Luigi; Kjaerheim, Kristina; Macfarlane, Gary J.; Macfarlane, Tatiana V.; Simonato, Lorenzo; Canova, Cristina; Agudo, Antonio; Lowry, Ray; Conway, David I.; McKinney, Patricia A.; Toner, Mary E.; Znaor, Ariana; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Boccia, Stefania; Cadoni, Gabriella; Arzani, Dario; Olshan, Andrew F.; Weissler, Mark C.; Funkhouser, William K.; Luo, Jingchun; Trubicka, Joanna; Lener, Marcin; Oszutowska, Dorota; Schwartz, Stephen M.; Fish, Sherianne; Doody, David R.; Muscat, Joshua E.; Lazarus, Philip; Gallagher, Carla J.; Chang, Shen-Chih; Zhang, Zuo-Feng; Wei, Qingyi; Sturgis, Erich M.; Wang, Li-E; Franceschi, Silvia; Herrero, Rolando; Kelsey, Karl T.; McClean, Michael D.; Marsit, Carmen J.; Nelson, Heather H.; Romkes, Marjorie; Buch, Shama; Nukui, Tomoko; Zhong, Shilong; Lacko, Martin; Manni, Johannes J.; Peters, Wilbert H. M.; Hung, Rayjean J.; Goodman, Gary E.; Liloglou, Triantafillos; Vineis, Paolo; Clavel-Chapelon, Francoise; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvatore; Navarro, Carmen; Ardanaz, Eva; Khaw, Kay-Tee; Key, Timothy; Bueno-de-Mesquita, H. Bas; Peeters, Petra H. M.; Trichopoulou, Antonia; Linseisen, Jakob; Boeing, Heiner; Overvad, Kim; Kumle, Merethe; Riboli, Elio; Metspalu, Andres; Zelenika, Diana; Boland, Anne; Delepine, Marc; Foglio, Mario; Lechner, Doris; Gut, Ivo G.; Galan, Pilar; Heath, Simon; Hashibe, Mia; Hayes, Richard B.; Lathrop, Mark; Brennan, Paul; Horwitz, Marshall S.; Lagiou, Pagona; Trichopoulos, Dimitrios; Castellsagué, Xavier; Wünsch-Filho, Victor; Neto, José Eluf; Garrote, Leticia Fernández; Lubiński, Jan; Chen, Chu; McLaughin, John; Vatten, Lars Johan; Njølstad, Inger; Field, John K; González, Carlos A; Quirós, J. Ramón; Martínez, Carmen; Larrañaga, Nerea; Hallmans, Göran; Tjønneland, Anne; Välk, Kristjan; Vooder, Tõnu; Blanché, Hélène; Boffetta, Paolo (Public Library of Science, 2011)
      Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation ...
    • Modern mammography screening and breast cancer mortality: population study 

      Weedon-Fekjær, Harald; Romundstad, Pål R; Vatten, Lars J (BMJ Publishing Group Ltd., 2014)
      Objective: To evaluate the effectiveness of contemporary mammography screening using individual information about screening history and breast cancer mortality from public screening programmes. Design: Prospective cohort ...
    • Pre-eclampsia, Soluble fms-like Tyrosine Kinase 1, and the Risk of Reduced Thyroid Function: Nested Case-Control and Population Based Study 

      Levine, Richard J; Vatten, Lars Johan; Horowitz, Gary Leigh; Qian, Cong; Romundstad, Pal R; Yu, Kai F; Hollenberg, Anthony Neil; Hellevik, Alf I; Asvold, Bjorn O; Karumanchi, Subbian Ananth (BMJ Publishing Group, 2009)
      Objective: To determine if pre-eclampsia is associated with reduced thyroid function during and after pregnancy. Design: Nested case-control study during pregnancy and population based follow-up study after pregnancy. ...
    • Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer 

      Wang, Yufei; McKay, James D; Rafnar, Thorunn; Wang, Zhaoming; Timofeeva, Maria N; Broderick, Peter; Zong, Xuchen; Laplana, Marina; Wei, Yongyue; Han, Younghun; Lloyd, Amy; Delahaye-Sourdeix, Manon; Chubb, Daniel; Gaborieau, Valerie; Wheeler, William; Chatterjee, Nilanjan; Thorleifsson, Gudmar; Sulem, Patrick; Liu, Geoffrey; Kaaks, Rudolf; Henrion, Marc; Kinnersley, Ben; Vallée, Maxime; LeCalvez-Kelm, Florence; Stevens, Victoria L; Gapstur, Susan M; Chen, Wei V; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Krokan, Hans E; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Vatten, Lars Johan; Njølstad, Inger; Chen, Chu; Goodman, Gary; Benhamou, Simone; Vooder, Tonu; Välk, Kristjan; Nelis, Mari; Metspalu, Andres; Lener, Marcin; Lubiński, Jan; Johansson, Mattias; Vineis, Paolo; Agudo, Antonio; Clavel-Chapelon, Francoise; Bueno-de-Mesquita, H Bas; Trichopoulos, Dimitrios; Khaw, Kay-Tee; Johansson, Mikael; Weiderpass, Elisabete; Tjønneland, Anne; Riboli, Elio; Lathrop, Mark; Scelo, Ghislaine; Albanes, Demetrius; Caporaso, Neil E; Ye, Yuanqing; Gu, Jian; Wu, Xifeng; Spitz, Margaret R; Dienemann, Hendrik; Rosenberger, Albert; Su, Li; Matakidou, Athena; Eisen, Timothy; Stefansson, Kari; Risch, Angela; Chanock, Stephen J; Christiani, David Christopher; Hung, Rayjean J; Brennan, Paul; Landi, Maria Teresa; Houlston, Richard S; Amos, Christopher I (Springer Nature, 2014)
      We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and ...