Now showing items 1-9 of 9

    • Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions 

      Vetrivelan, Ramalingam; Saper, Clifford B; Fuller, Patrick M (Dove Medical Press, 2014)
      Armodafinil is the pharmacologically active R-enantiomer of modafinil, a widely prescribed wake-promoting agent used to treat several sleep-related disorders including excessive daytime sleepiness associated with narcolepsy, ...
    • Coding of Internal Senses: Vagal Gut-to-Brain Circuits 

      Williams, Erika Kristen (2016-05-17)
      Our ability to detect features of environments in and around us is fundamental. Organisms have developed highly specialized systems to allow for transduction of a broad variety of stimuli to convey sensory information to ...
    • Functional organization of the circadian timing system 

      Vujovic, Nina (2014-02-25)
      The circadian timing system establishes daily rhythms in behavior and physiology throughout the body, ensuring that functions like activity, sleep and hormone release are appropriately timed. Research suggests that his ...
    • GABAergic parafacial zone is a medullary slow–wave–sleep promoting center 

      Anaclet, Christelle; Ferrari, Loris; Arrigoni, Elda; Bass, Caroline E.; Saper, Clifford B.; Lu, Jun; Fuller, Patrick M. (2014)
      Work in animals and humans suggest the existence of a slow–wave sleep (SWS) promoting/EEG synchronizing center in the mammalian lower brainstem. While sleep–active GABAergic neurons in the medullary parafacial zone (PZ) ...
    • The Neuroscience Peer Review Consortium 

      Saper, Clifford B.; Maunsell, John; Sagvolden, Terje (BioMed Central, 2009)
      The Neuroscience Peer Review Consortium (NPRC) was conceived in the summer of 2007 at a meeting of editors and publishers of neuroscience journals. One of the working groups addressed whether it was possible to construct ...
    • The Neuroscience Peer Review Consortium 

      Saper, Clifford B.; Maunsell, John H. R. (BioMed Central, 2009)
      As the Neuroscience Peer Review Consortium (NPRC) ends its first year, it is worth looking back to see how the experiment has worked. In order to encourage dissemination of the details outlined in this Editorial, it will ...
    • A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale 

      Bohland, Jason W.; Wu, Caizhi; Barbas, Helen; Bokil, Hemant; Bota, Mihail; Cline, Hollis T.; Freed, Peter J.; Greenspan, Ralph J.; Haber, Suzanne N.; Hawrylycz, Michael; Hilgetag, Claus C.; Jones, Allan; Karten, Harvey J.; Kleinfeld, David; Kötter, Rolf; Lester, Henry A.; Lin, John M.; Mikula, Shawn; Panksepp, Jaak; Price, Joseph L.; Safdieh, Joseph; Schiff, Nicholas D.; Stillman, Bruce W.; Svoboda, Karel; Swanson, Larry W.; Toga, Arthur W.; Van Essen, David C.; Mitra, Partha P.; Sporns, Olaf; Breiter, Hans Charles; Doyle, John C.; Herrera, Daniel Gustavo; Huang, Z. Josh; Jones, Edward G.; Mensh, Brett Daren; Saper, Clifford B.; Schmahmann, Jeremy Dan; Watson, James D. (Public Library of Science, 2009)
      In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for ...
    • The Rat Ventromedial Prefrontal Cortex in the Neural Circuitries of Depression and Sleep 

      Chang, Celene Hyunju (2013-09-26)
      Major depressive disorder (MDD) is a debilitating disorder affecting hundreds of millions of people worldwide. The etiology of the disease is unknown, and how antidepressant medications reverse depression is unclear. ...
    • Signal Integration and Diversification by Melanopsin-Expressing Retinal Ganglion Cells 

      Emanuel, Alan (2016-05-10)
      There are three classes of light-sensing cells in the mammalian retina: rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). This dissertation focuses on the signals generated by the ipRGCs, which ...