Browsing by Author "Feany, Mel"

Now showing items 1-8 of 8

    • Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo 

      Cullen, Valerie; Lindfors, Maria; Ng, Juliana; Paetau, Anders; Swinton, Erika; Kolodziej, Piotr; Boston, Heather; Saftig, Paul; Woulfe, John; Myllykangas, Liisa; Schlossmacher, Michael G; Tyynelä, Jaana; Feany, Mel B. (BioMed Central, 2009)
      Background: Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for ...

    • Characterization of Dopamine-Responsive Serotonergic Neurons Underlying Aggression Modulation 

      Asher, Vidette E. (2016-04-04)
      The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ...

    • Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model 

      Okamoto, Yoko; Shirakashi, Yoshitomo; Ihara, Masafumi; Urushitani, Makoto; Oono, Miki; Kawamoto, Yasuhiro; Yamashita, Hirofumi; Shimohama, Shun; Kato, Shinsuke; Hirano, Asao; Tomimoto, Hidekazu; Ito, Hidefumi; Takahashi, Ryosuke; Feany, Mel B. (Public Library of Science, 2011)
      Background and Purpose: Cu/Zn superoxide dismutase (SOD1) is a major component of Lewy body-like hyaline inclusion (LBHI) found in the postmortem tissue of SOD1-linked familial amyotrophic lateral sclerosis (FALS) patients. ...

    • Disruption of Mitochondrial Dynamics in Tauopathy 

      DuBoff, Brian Michael (2013-02-06)
      Alzheimer’s disease (AD) is characterized pathologically by proteinaceous aggregates composed primarily of amyloid \(\beta (A \beta)\) and tau. Diseases characterized by abnormal deposition of tau are collectively termed ...

    • Inactivation of Drosophila Huntingtin Affects Long-Term Adult Functioning and the Pathogenesis of a Huntington's Disease Model 

      Zhang, Sheng; Feany, Mel; Saraswati, Sudipta; Littleton, J. Troy; Perrimon, Norbert (The Company of Biologists, 2009-05)
      A polyglutamine expansion in the huntingtin (HTT) gene causes neurodegeneration in Huntington’s disease (HD), but the in vivo function of the native protein (Htt) is largely unknown. Numerous biochemical and in vitro studies ...

    • Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo 

      Khurana, Vikram; Elson-Schwab, Ilan; Fulga, Tudor Alexandru; Sharp, Katherine A.; Loewen, Carin A.; Mulkearns, Erin; Tyynelä, Jaana; Scherzer, Clemens; Feany, Mel B. (Public Library of Science, 2010)
      Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal ...

    • Nitric oxide mediates glial-induced neurodegeneration in Alexander disease 

      Wang, Liqun; Hagemann, Tracy L.; Kalwa, Hermann; Michel, Thomas; Messing, Albee; Feany, Mel B. (Nature Pub. Group, 2015)
      Glia play critical roles in maintaining the structure and function of the nervous system; however, the specific contribution that astroglia make to neurodegeneration in human disease states remains largely undefined. Here ...

    • Tau promotes neurodegeneration through global chromatin relaxation 

      Frost, Bess; Hemberg, Martin; Lewis, Jada; Feany, Mel B. (2014)
      The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Previous studies link oxidative stress and subsequent DNA damage to neuronal death in AD ...