Browsing by Author "Wagner, Denisa"

Now showing items 1-7 of 7

    • ADAMTS13: A New Link Between Thrombosis and Inflammation 

      Chauhan, Anil K.; Kisucka, Janka; Brill, Alexander; Walsh, Meghan T.; Scheiflinger, Friedrich; Wagner, Denisa D. (The Rockefeller University Press, 2008)
      von Willebrand factor (VWF) levels are elevated and a disintegrin-like and metalloprotease with thrombospondin type I repeats–13 (ADAMTS13) activity is decreased in both acute and chronic inflammation. We hypothesized that ...

    • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation 

      Lewis, Huw D.; Liddle, John; Coote, Jim E.; Atkinson, Stephen J.; Barker, Michael D.; Bax, Benjamin, D.; Bicker, Kevin L.; Bingham, Ryan P.; Campbell, Matthew; Chen, Yu Hua; Chung, Chun-wa; Craggs, Peter D.; Davis, Rob P.; Eberhard, Dirk; Joberty, Gerard; Lind, Kenneth E.; Locke, Kelly; Maller, Claire; Martinod, Kimberly; Patten, Chris; Polyakova, Oxana; Rise, Cecil E.; Rüdiger, Martin; Sheppard, Robert J.; Slade, Daniel J.; Thomas, Pamela; Thorpe, Jim; Yao, Gang; Drewes, Gerard; Wagner, Denisa D.; Thompson, Paul R.; Prinjha, Rab K.; Wilson, David M. (2015)
      PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient ...

    • Inhibition of VEGF or TGF-  Signaling Activates Endothelium and Increases Leukocyte Rolling 

      Walshe, Tony E.; Dole, Vandana S.; Maharaj, Arindel S.R.; Patten, Ian S.; Wagner, Denisa D.; D'Amore, Patricia Ann (Ovid Technologies (Wolters Kluwer Health), 2009)
      Objective Motivated by the central roles that VEGF and TGF-β play in the assembly and maintenance of the vasculature, we examined the impact of systemic VEGF or TGF-β signal inhibition on endothelial activation as ...

    • Integrin-Independent Role of CalDAG-GEFI in Neutrophil Chemotaxis 

      Carbo, Carla; Duerschmied, Daniel; Goerge, Tobias; Hattori, Hidenori; Sakai, Jiro; Cifuni, Stephen M.; White, Gilbert C.; Chrzanowska-Wodnicka, Magdalena; Luo, Hongbo; Wagner, Denisa D. (Society for Leukocyte Biology, 2010)
      Chemotaxis and integrin activation are essential processes for neutrophil transmigration in response to injury. CalDAG-GEFI plays a key role in the activation of β1, β2, and β3 integrins in platelets and neutrophils by ...

    • Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities 

      Suidan, Georgette L; Duerschmied, Daniel; Dillon, Gregory; Vanderhorst, Veronique; Hampton, Thomas G.; Wong, Siu Ling Christine; Voorhees, Jaymie R.; Wagner, Denisa D. (Public Library of Science, 2013)
      The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal ...

    • Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo 

      von Brühl, Marie-Luise; Stark, Konstantin; Steinhart, Alexander; Chandraratne, Sue; Konrad, Ildiko; Lorenz, Michael; Khandoga, Alexander; Tirniceriu, Anca; Coletti, Raffaele; Köllnberger, Maria; Byrne, Robert A.; Laitinen, Iina; Walch, Axel; Brill, Alexander; Pfeiler, Susanne; Manukyan, Davit; Braun, Siegmund; Lange, Philipp; Riegger, Julia; Ware, Jerry; Eckart, Annekathrin; Haidari, Selgai; Rudelius, Martina; Schulz, Christian; Echtler, Katrin; Brinkmann, Volker; Schwaiger, Markus; Preissner, Klaus T.; Wagner, Denisa D.; Mackman, Nigel; Engelmann, Bernd; Massberg, Steffen (The Rockefeller University Press, 2012)
      Deep vein thrombosis (DVT) is a major cause of cardiovascular death. The sequence of events that promote DVT remains obscure, largely as a result of the lack of an appropriate rodent model. We describe a novel mouse model ...

    • Neutrophil extracellular traps 

      Demers, Mélanie; Wagner, Denisa D. (Landes Bioscience, 2013)
      Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) ...