Now showing items 1-20 of 29

    • AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair 

      Cha, Jong-Ho; Wee, Hee-Jun; Seo, Ji Hae; Ahn, Bum Ju; Park, Ji-Hyeon; Yang, Jun-Mo; Lee, Sae-Won; Kim, Eun Hee; Lee, Ok-Hee; Heo, Ji Hoe; Lee, Hyo-Jong; Gelman, Irwin H.; Arai, Ken; Lo, Eng H.; Kim, Kyu-Won (Public Library of Science, 2014)
      The repair process after CNS injury shows a well-organized cascade of three distinct stages: inflammation, new tissue formation, and remodeling. In the new tissue formation stage, various cells migrate and form the fibrotic ...
    • CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling 

      Hayakawa, Kazuhide; Wang, Xiaohua; Lo, Eng H. (Wiley, 2016)
      The concept of macrophage polarization toward different phenotypes after CNS injury has been increasingly discussed. Here, we propose that CD200 treatment may help shift pro-inflammatory macrophages to an arginase 1 (Arg1)-, ...
    • CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation 

      Hayakawa, Kazuhide; Pham, Loc-Duyen; Seo, Ji-Hae; Miyamoto, Nobukazu; Maki, Takakuni; Sakadzic, Sava; Boas, David A.; van Leyen, Klaus J.; Waeber, Christian; Kim, Kyu-Won; Arai, Ken; Lo, Eng H. (SAGE Publications, 2016)
      There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ...
    • Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection 

      Kahle, Kristopher; Walcott, Brian; Nahed, Brian Vala; Barnard, Zachary R.; Lo, Eng H.; Buonanno, Ferdinando Stelio; Venna, Nagagopal; Ning, MingMing (Elsevier BV, 2011)
      Acute encephalitis, encephalopathy, and seizures are known rare neurologic sequelae of respiratory tract infection with seasonal influenza A and B virus, but the neurological complications of the pandemic 2009 swine influenza ...
    • Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy 

      Jiang, Yinghua; Fan, Xiang; Yu, Zhanyang; Liao, Zhengbu; Wang, Xiao-Shu; van Leyen, Klaus; Sun, Xiaochuan; Lo, Eng H.; Wang, Xiaoying (Frontiers Media S.A., 2015)
      Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA ...
    • Combination Therapy with Normobaric Oxygen (NBO) Plus Thrombolysis in Experimental Ischemic Stroke 

      Fujiwara, Norio; Murata, Yoshihiro; Arai, Ken; Egi, Yasuhiro; Lu, Jie; Wu, Ona; Singhal, Aneesh B.; Lo, Eng H. (BioMed Central, 2009)
      Background: The widespread use of tissue plasminogen activator (tPA), the only FDA-approved acute stroke treatment, remains limited by its narrow therapeutic time window and related risks of brain hemorrhage. Normobaric ...
    • Cystathionine β-Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury 

      Chan, Su Jing; Chai, Chou; Lim, Tze Wei; Yamamoto, Mie; Lo, Eng H; Lai, Mitchell Kim Peng; Wong, Peter Tsun Hon (SAGE Publications, 2015)
      Hydrogen sulfide (H2S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine β-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system. When SH-SY5Y ...
    • Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain 

      Navaratna, Deepti; Guo, Shu-Zhen; Hayakawa, Kazhuhide; Wang, Xiaoying; Gerhardinger, Chiara; Lo, Eng H. (American Diabetes Association, 2011)
      Objective: Diabetes is an independent risk factor for stroke. However, the underlying mechanism of how diabetes confers that this risk is not fully understood. We hypothesize that secretion of neurotrophic factors by the ...
    • Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells 

      Koh, Seong-Ho; Liang, Anna C.; Takahashi, Yoko; Maki, Takakuni; Shindo, Akihiro; Osumi, Noriko; Zhao, Jing; Lin, Hong; Holder, Julie C.; Chuang, Tsu Tshen; McNeish, John D.; Arai, Ken; Lo, Eng H. (Public Library of Science, 2015)
      Adult mammalian brain can be plastic after injury and disease. Therefore, boosting endogenous repair mechanisms would be a useful therapeutic approach for neurological disorders. Isoxazole-9 (Isx-9) has been reported to ...
    • Experimental Models for Analysis of Oligodendrocyte Pathophysiology in Stroke 

      Arai, Ken; Lo, Eng H. (BioMed Central, 2009)
      White matter damage is a clinically important part of stroke. However, compared to the mechanisms of neuronal injury in gray matter, white matter pathophysiology remains relatively understudied and poorly understood. This ...
    • Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice 

      Foerch, Christian; Rosidi, Nathanael L.; Schlunk, Frieder; Lauer, Arne; Cianchetti, Flor A.; Mandeville, Emiri T; Arai, Ken; Yigitkanli, Kazim; Fan, Xiang; Wang, Xiaoying; van Leyen, Klaus J.; Steinmetz, Helmuth; Schaffer, Chris B.; Lo, Eng H. (Public Library of Science, 2013)
      Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral ...
    • Large arteriolar component of oxygen delivery implies safe margin of oxygen supply to cerebral tissue 

      Sakadžić, Sava; Mandeville, Emiri T.; Gagnon, Louis; Musacchia, Joseph J.; Yaseen, Mohammad A.; Yucel, Meryem A; Lefebvre, Joel; Lesage, Frédéric; Dale, Anders M.; Eikermann-Haerter, Katharina; Ayata, Cenk; Srinivasan, Vivek J.; Lo, Eng H.; Devor, Anna; Boas, David A. (2014)
      What is the organization of cerebral microvascular oxygenation and morphology that allows adequate tissue oxygenation at different activity levels? We address this question in the mouse cerebral cortex using microscopic ...
    • Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage 

      Esposito, Elga; Mandeville, Emiri T; Lo, Eng H (BioMed Central, 2013)
      Background: Intracerebral hemorrhage is a subtype of stroke that has a poor prognosis without an adequate therapy. Recently, the use of anesthetics such as isoflurane has been shown to be protective after cerebral ischemia. ...
    • Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases 

      Maki, Takakuni; Liang, Anna C.; Miyamoto, Nobukazu; Lo, Eng H.; Arai, Ken (Frontiers Media S.A., 2013)
      White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at ...
    • Multiparametric, Longitudinal Optical Coherence Tomography Imaging Reveals Acute Injury and Chronic Recovery in Experimental Ischemic Stroke 

      Srinivasan, Vivek J.; Mandeville, Emiri T.; Can, Anil; Blasi, Francesco; Climov, Mihail; Daneshmand, Ali; Lee, Jeong Hyun; Yu, Esther; Radhakrishnan, Harsha; Lo, Eng H.; Sakadžić, Sava; Eikermann-Haerter, Katharina; Ayata, Cenk (Public Library of Science, 2013)
      Progress in experimental stroke and translational medicine could be accelerated by high-resolution in vivo imaging of disease progression in the mouse cortex. Here, we introduce optical microscopic methods that monitor ...
    • Neuregulin1-β Decreases IL-1β -Induced Neutrophil Adhesion to Human Brain Microvascular Endothelial Cells 

      Wu, Limin; Walas, Samantha; Leung, Wendy; Sykes, David Brian; Wu, Jiang; Lo, Eng H.; Lok, Josephine M. (Springer Nature, 2014)
      Neuroinflammation contributes to the pathophysiology of diverse diseases including stroke, traumatic brain injury, Alzheimer's Disease, Parkinson's Disease, and multiple sclerosis, resulting in neurodegeneration and loss ...
    • Neuroglobin-overexpression reduces traumatic brain lesion size in mice 

      Zhao, Song; Yu, Zhanyang; Xing, Changhong; Hayakawa, Kazuhide; Whalen, Michael Jerome; Lok, Josephine M.; Lo, Eng H.; Wang, Xiaoying (BioMed Central, 2012)
      Background: Accumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries. In this study we tested the neuroprotective effects of Ngb over-expression ...
    • OCT Methods for Capillary Velocimetry 

      Srinivasan, Vivek Jay; Radhakrishnan, Harsha; Lo, Eng H.; Mandeville, Emiri T; Jiang, James Y.; Barry, Scott; Cable, Alex E. (Optical Society of America, 2012)
      To date, two main categories of OCT techniques have been described for imaging hemodynamics: Doppler OCT and OCT angiography. Doppler OCT can measure axial velocity profiles and flow in arteries and veins, while OCT ...
    • Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling 

      Seo, Ji Hae; Maki, Takakuni; Maeda, Mitsuyo; Miyamoto, Nobukazu; Liang, Anna C.; Hayakawa, Kazuhide; Pham, Loc-Duyen D.; Suwa, Fumihiko; Taguchi, Akihiko; Matsuyama, Tomohiro; Ihara, Masafumi; Kim, Kyu-Won; Lo, Eng H.; Arai, Ken (Public Library of Science, 2014)
      Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) ...
    • Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid 

      Maki, Takakuni; Okamoto, Yoko; Carare, Roxana O; Hase, Yoshiki; Hattori, Yorito; Hawkes, Cheryl A; Saito, Satoshi; Yamamoto, Yumi; Terasaki, Yasukazu; Ishibashi-Ueda, Hatsue; Taguchi, Akihiko; Takahashi, Ryosuke; Miyakawa, Taihei; Kalaria, Raj N; Lo, Eng H; Arai, Ken; Ihara, Masafumi (Blackwell Publishing Ltd, 2014)
      Objective: Brain amyloidosis is a key feature of Alzheimer's disease (AD). It also incorporates cerebrovascular amyloid β (Aβ) in the form of cerebral amyloid angiopathy (CAA) involving neurovascular dysfunction. We have ...