Browsing by Author "Duke-Cohan, Jonathan"
Now showing items 1-6 of 6
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CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells
Naito, Masayasu; Hainz, Ursula; Burkhardt, Ute E.; Fu, Buyin; Ahove, Deborah; Stevenson, Kristen E.; Rajasagi, Mohini; Zhu, Baogong; Alonso, Anselmo; Witten, Elizabeth; Matsuoka, Ken-ichi; Neuberg, Donna; Duke-Cohan, Jonathan S.; Wu, Cathy Ju-Ying; Freeman, Gordon James (Springer-Verlag, 2012)CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available. Like other TNF family members, in ... -
Dipeptidyl Peptidase IV Activity and/or Structure Homologs: Contributing Factors in the Pathogenesis of Rheumatoid Arthritis?
Sedo, Aleksi; Duke-Cohan, Jonathan S.; Balaziova, Eva; Sedova, Liliana R (BioMed Central, 2005)Several of the proinflammatory peptides involved in rheumatoid arthritis pathogenesis, including peptides induced downstream of tumor necrosis factor-α as well as the monocyte/T cell-attracting chemokines RANTES and stromal ... -
Genetic Fixity in the Human Major Histocompatibility Complex and Block Size Diversity in the Class I Region Including HLA-E
Romero, Viviana; Romero, Tatiana; Clavijo, Olga P; Fici, Dolores A; Alford, Dennis R; Awdeh, Zuheir L; Zuñiga, Joaquin; El-Dahdah, Lama; Larsen, Charles E.; Duke-Cohan, Jonathan S.; Fox, Edward Alvin; Husain, Zaheed; Almeciga, Ingrid; Alper, Chester A.; Yunis, Edmond J. (BioMed Central, 2007)Background: The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association. Results: Here, we present HLA-E ... -
Plxnd1 Expression in Thymocytes Regulates Their Intrathymic Migration While That in Thymic Endothelium Impacts Medullary Topology
Choi, Young I.; Duke-Cohan, Jonathan S.; Tan, Jing; Gui, Jingang; Singh, Manvendra K.; Epstein, Jonathan A.; Reinherz, Ellis L. (Frontiers Media S.A., 2013)An important role for plexinD1 in thymic development is inferred from studies of germline Plxnd1 knockout (KO) mice where mislocalized CD69+ thymocytes as well as ectopic thymic subcapsular medullary structures were observed. ... -
Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity
Duke-Cohan, Jonathan; Ishikawa, Yuki; Yoshizawa, Akihiro; Choi, Young-Il; Lee, Chin-Nien; Acuto, Oreste; Kissler, Stephan; Reinherz, Ellis L. (American Association for the Advancement of Science (AAAS), 2018-06-12)Multiple autoimmune pathologies are associated with single-nucleotide polymorphisms of the human gene TAGAP, which encodes TAGAP, a guanosine triphosphatase (GTPase)-activating protein. We showed in mice that Tagap-mediated ... -
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
Xiao, Yanping; Yu, Sanhong; Zhu, Baogong; Bedoret, Denis; Bu, Xia; Francisco, Loise M.; Hua, Ping; Duke-Cohan, Jonathan S.; Umetsu, Dale T.; Sharpe, Arlene H.; DeKruyff, Rosemarie H.; Freeman, Gordon J. (The Rockefeller University Press, 2014)We report that programmed death ligand 2 (PD-L2), a known ligand of PD-1, also binds to repulsive guidance molecule b (RGMb), which was originally identified in the nervous system as a co-receptor for bone morphogenetic ...