Now showing items 1-20 of 23

    • Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis 

      Chanock, Stephen J.; Schafer, Eric J.; Tabernero, Josep; Baselga, José; Oh, William K.; Pomerantz, Mark M; Shrestha, Yashaswi; Flavin, Richard John; Regan, Meredith Margaret; Penney, Kathryn Lee; Mucci, Lorelei Ann; Stampfer, Meir; Hunter, David J.; Chan, Jennifer Ang; Richardson, Andrea Lynn; Loda, Massimo; Kantoff, Philip Wayne; Hahn, William C.; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target ...
    • The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis 

      Pomerantz, Mark M.; Li, Fugen; Takeda, David; Lenci, Romina; Chonkar, Apurva; Chabot, Matthew; Cejas, Paloma; Vazquez, Francisca; Cook, Jennifer; Shivdasani, Ramesh A.; Bowden, Michaela; Lis, Rosina; Hahn, William C.; Kantoff, Philip W.; Brown, Myles; Loda, Massimo; Long, Henry W.; Freedman, Matthew L. (2015)
      Master transcription factors interact with DNA to establish cell-type identity and to regulate gene expression in mammalian cells1,2. The genome-wide map of these transcription factor binding sites has been termed the ...
    • BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma 

      Jeong, Joseph H.; Wang, Zhenxiong; Ouyang, Xuesong; Jiang, Shan; Guney, Isil; Kang, Gyeong Hoon; Abate-Shen, Cory; Guimaraes, Alexander Savio Ramos; Figueiredo, Jose L.; Ding, Zhihu; Shin, Eyoung; Hahn, William C.; Loda, Massimo; Weissleder, Ralph; Chin, Lynda (Public Library of Science, 2008)
      Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic ...
    • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer 

      Lunardi, Andrea; Ala, Ugo; Epping, Mirjam T.; Salmena, Leonardo; Clohessy, John G.; Webster, Kaitlyn A.; Wang, Guocan; Mazzucchelli, Roberta; Bianconi, Maristella; Stack, Edward C.; Lis, Rosina; Patnaik, Akash; Cantley, Lewis C.; Bubley, Glenn; Cordon-Cardo, Carlos; Gerald, William L.; Montironi, Rodolfo; Signoretti, Sabina; Loda, Massimo; Nardella, Caterina; Pandolfi, Pier Paolo (2013)
      Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that ...
    • DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors 

      Bambury, Richard M; Bhatt, Ami S; Riester, Markus; Pedamallu, Chandra Sekhar; Duke, Fujiko; Bellmunt, Joaquim; Stack, Edward C; Werner, Lillian; Park, Rachel; Iyer, Gopa; Loda, Massimo; Kantoff, Philip W; Michor, Franziska; Meyerson, Matthew; Rosenberg, Jonathan E (BioMed Central, 2015)
      Background: To date, there have been no reports characterizing the genome-wide somatic DNA chromosomal copy-number alteration landscape in metastatic urothelial carcinoma. We sought to characterize the DNA copy-number ...
    • DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues 

      Craig, Justin M.; Vena, Natalie; Idbaih, Ahmed; Fouse, Shaun D.; Ozek, Memet; Sav, Aydin; Margraf, Linda R.; Eberhart, Charles G.; Norden, Andrew D.; Ramkissoon, Shakti; Hill, D. Ashley; Kieran, Mark W.; Wen, Patrick Yung Chih; Loda, Massimo; Santagata, Sandro; Ligon, Keith Lloyd; Ligon, Azra Hadi (Public Library of Science, 2012)
      Whole-genome copy number analysis platforms, such as array comparative genomic hybridization (aCGH) and single nucleotide polymorphism (SNP) arrays, are transformative research discovery tools. In cancer, the identification ...
    • The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset 

      Ceol, Craig J.; Houvras, Yariv; Jane-Valbuena, Judit; Bilodeau, Steve; Orlando, David A.; Battisti, Valentine; Fritsch, Lauriane; Lin, William Michael; Hollmann, Travis J.; Ferré, Fabrizio; Bourque, Caitlin; Burke, Christopher J.; Turner, Laura; Uong, Audrey; Johnson, Laura A.; Beroukhim, Rameen; Mermel, Craig Harold; Loda, Massimo; Ait-Si-Ali, Slimane; Garraway, Levi Alexander; Young, Richard A.; Zon, Leonard Ira (Nature Publishing Group, 2011)
    • Literature Lab: A Method of Automated Literature Interrogation to Infer Biology from Microarray Analysis 

      Febbo, Phillip G; Mulligan, Mike G; Slonina, David A; Stegmeir, Kimberly; Di Vizio, Dolores; Martinez, Paul R.; Loda, Massimo; Taylor, Stephen (BioMed Central, 2007)
      Background: The biomedical literature is a rich source of associative information but too vast for complete manual review. We have developed an automated method of literature interrogation called "Literature Lab" that ...
    • Lung Adenocarcinoma with EGFR Amplification Has Distinct Clinicopathologic and Molecular Features in Never-Smokers 

      Sholl, Lynette Marie; Yeap, Beow Yong; Iafrate, Anthony John; Holmes-Tisch, A. J.; Chou, Y.-P.; Wu, Ming-Tsang; Goan, Y.-G.; Su, Li; Benedettini, E.; Yu, J.; Loda, Massimo; Janne, Pasi Antero; Christiani, David Christopher; Chirieac, Lucian Radu (American Association for Cancer Research (AACR), 2009)
      In a subset of lung adenocarcinomas the epidermal growth factor receptor (EGFR) is activated by kinase domain mutations and/or gene amplification, but the interaction between the two types of abnormalities is complex and ...
    • A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis 

      Zadra, Giorgia; Photopoulos, Cornelia; Tyekucheva, Svitlana; Heidari, Pedram; Weng, Qing Ping; Fedele, Giuseppe; Liu, Hong; Scaglia, Natalia; Priolo, Carmen; Sicinska, Ewa; Mahmood, Umar; Signoretti, Sabina; Birnberg, Neal; Loda, Massimo (Backwell Publishing Ltd, 2014)
      5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of ...
    • p63 promotes cell survival through fatty acid synthase 

      Sabbisetti, Venkata S; Di Napoli, Arianna; Seeley, Apryle; Amato, Angela M.; O'Regan, Esther; Ghebremichael, Musie Syum; Loda, Massimo; Signoretti, Sabina (Public Library of Science, 2009)
      There is increasing evidence that p63, and specifically ΔNp63, plays a central role in both development and tumorigenesis by promoting epithelial cell survival. However, few studies have addressed the molecular mechanisms ...
    • Paired Exome Analysis of Barrett’s Esophagus and Adenocarcinoma 

      Stachler, Matthew D.; Taylor-Weiner, Amaro; Peng, Shouyong; McKenna, Aaron; Agoston, Agoston T.; Odze, Robert D.; Davison, Jon M.; Nason, Katie S.; Loda, Massimo; Leshchiner, Ignaty; Stewart, Chip; Stojanov, Petar; Seepo, Sara; Lawrence, Michael S.; Ferrer-Torres, Daysha; Lin, Jules; Chang, Andrew C.; Gabriel, Stacey B.; Lander, Eric S.; Beer, David G.; Getz, Gad; Carter, Scott L.; Bass, Adam J. (2015)
      Barrett’s esophagus, is thought to progress to esophageal adenocarcinoma (EAC) through a step-wise progression with loss of CDKN2A followed by p53 inactivation and aneuploidy. Here, we present whole exome sequencing from ...
    • Polycomb-independent activity of EZH2 in castration resistant prostate cancer 

      Xu, Kexin; Wu, Zhenhua; Groner, Anna Claire; He, Housheng H; Cai, Changmeng; Stack, Edward C; Loda, Massimo; Liu, Tao; Morrissey, Colm; Vessella, Robert L; Kantoff, Philip Wayne; Balk, Steven Paul; Liu, Xiaole Shirley; Brown, Myles Avery (BioMed Central, 2013)
    • Potential Role of miR-9 and miR-223 in Recurrent Ovarian Cancer 

      Laios, Alexandros; O'Toole, Sharon; Martin, Cara; Kelly, Lynn; Ring, Martina; Finn, Stephen P; Barrett, Ciara; Gleeson, Noreen; D'Arcy, Tom; McGuinness, Eamonn; Sheils, Orla; O' Leary, John; Flavin, Richard John; Loda, Massimo; Sheppard, Brian (BioMed Central, 2008)
      Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable ...
    • Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity 

      Majumder, Biswanath; Baraneedharan, Ulaganathan; Thiyagarajan, Saravanan; Radhakrishnan, Padhma; Narasimhan, Harikrishna; Dhandapani, Muthu; Brijwani, Nilesh; Pinto, Dency D.; Prasath, Arun; Shanthappa, Basavaraja U.; Thayakumar, Allen; Surendran, Rajagopalan; Babu, Govind K.; Shenoy, Ashok M.; Kuriakose, Moni A.; Bergthold, Guillaume; Horowitz, Peleg; Loda, Massimo; Beroukhim, Rameen; Agarwal, Shivani; Sengupta, Shiladitya; Sundaram, Mallikarjun; Majumder, Pradip K. (Nature Pub. Group, 2015)
      Predicting clinical response to anticancer drugs remains a major challenge in cancer treatment. Emerging reports indicate that the tumour microenvironment and heterogeneity can limit the predictive power of current ...
    • The Role of the Ubiquitination–Proteasome Pathway in Breast Cancer: Use of Mouse Models for Analyzing Ubiquitination Processes 

      Rossi, Sabrina; Loda, Massimo (BioMed Central, 2003)
      Turnover of several regulatory proteins results from targeted destruction via ubiquitination and subsequent degradation through the proteosome. The timely and irreversible degradation of critical regulators is essential ...
    • The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study 

      Kelly, Rachel S.; Sinnott, Jennifer A.; Rider, Jennifer R.; Ebot, Ericka M.; Gerke, Travis; Bowden, Michaela; Pettersson, Andreas; Loda, Massimo; Sesso, Howard D.; Kantoff, Philip W.; Martin, Neil E.; Giovannucci, Edward L.; Tyekucheva, Svitlana; Heiden, Matthew Vander; Mucci, Lorelei A. (BioMed Central, 2016)
      Background: Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism ...
    • Serum glucose and risk of cancer: a meta-analysis 

      Crawley, Danielle J; Holmberg, Lars; Melvin, Jennifer C; Loda, Massimo; Chowdhury, Simon; Rudman, Sarah M; Van Hemelrijck, Mieke (BioMed Central, 2014)
      Background: Raised serum glucose has been linked to increased risk of many solid cancers. We performed a meta-analysis to quantify and summarise the evidence for this link. Methods: Pubmed and Embase were reviewed, using ...
    • Serum Lipid Profiles and Cancer Risk in the Context of Obesity: Four Meta-Analyses 

      Melvin, Jennifer C.; Holmberg, Lars; Rohrmann, Sabine; Loda, Massimo; Van Hemelrijck, Mieke (Hindawi Publishing Corporation, 2013)
      The objective here was to summarize the evidence for, and quantify the link between, serum markers of lipid metabolism and risk of obesity-related cancers. PubMed and Embase were searched using predefined inclusion criteria ...
    • A Synthetic Form of Frizzled 8-Associated Antiproliferative Factor Enhances p53 Stability through USP2a and MDM2 

      Kim, Jayoung; Keay, Susan K.; You, Sungyong; Loda, Massimo; Freeman, Michael R. (Public Library of Science, 2012)
      Frizzled 8-associated Antiproliferative Factor (APF) is a sialoglycopeptide urinary biomarker of interstitial cystitis/painful bladder syndrome (IC/PBS), a chronic condition of unknown etiology with variable symptoms that ...