Now showing items 1-10 of 10

    • Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer 

      Schietinger, Andrea; Arina, Ainhoa; Liu, Rebecca B; Wells, Sam; Huang, Jianhua; Engels, Boris; Bindokas, Vytas; Bartkowiak, Todd; Lee, David; Herrmann, Andreas; Piston, David W; Pittet, Mikael J; Lin, P Charles; Zal, Tomasz; Schreiber, Hans (Landes Bioscience, 2013)
      A fluorescence-based, high-resolution imaging approach was used to visualize longitudinally the cellular events unfolding during T cell-mediated tumor destruction. The dynamic interplay of T cells, cancer cells, cancer ...
    • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata 

      Swirski, Filip K.; Libby, Peter; Aikawa, Elena; Alcaide, Pilar; Luscinskas, Francis William; Weissleder, Ralph; Pittet, Mikael J. (American Society for Clinical Investigation, 2007)
      Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative ...
    • Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors 

      Wildgruber, Moritz; Chudnovskiy, Aleksey; Yoon, Tae-Jong; Etzrodt, Martin; Lee, Hakho; Pittet, Mikael J.; Nahrendorf, Matthias; Croce, Kevin James; Libby, Peter; Weissleder, Ralph; Swirski, Filip K. (Public Library of Science, 2009)
      Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...
    • Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium 

      Lau, Ken; Cortez-Retamozo, Virna; Philips, Sarah R.; Pittet, Mikael J.; Lauffenburger, Douglas A.; Haigis, Kevin M (Public Library of Science, 2012)
      An intercellular communication network that controls intestinal homeostasis in animals treated acutely with the pro-inflammatory cytokine TNF-α is uncovered by multi-scale systems analysis.
    • Myocardial Infarction Accelerates Atherosclerosis 

      Leuschner, Florian; Robbins, Clinton; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T.; Chicoine, Adam T.; van der Laan, Anja M.; Niessen, Hans W.M.; Piek, Jan J.; Rubin, Barry B.; Butany, Jagdish; Katus, Hugo A.; Murphy, Sabina A.; Pittet, Mikael J.; Lin, Charles P.; Dutta, Partha; Courties, Gabriel P; Wei, Ying; Gorbatov, Rostic; Majmudar, Maulik D; Stone, James Robert; Morrow, David Andrew; Sabatine, Marc Steven; Vinegoni, Claudio; Moskowitz, Michael Arthur; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Nature Publishing Group, 2012)
      During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...
    • A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses 

      Berger, Cedric R.; Figueiredo, Jose-Luiz; Swirski, Filip K.; Mempel, Thorsten Roman; Von Andrian, Ulrich H.; Pittet, Mikael J.; Weissleder, Ralph (Public Library of Science, 2007)
      The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging ...
    • Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis 

      Leuschner, Florian; Rauch, Philipp J.; Ueno, Takuya; Gorbatov, Rostic; Marinelli, Brett; Lee, Won Woo; Dutta, Partha; Wei, Ying; Robbins, Clinton; Iwamoto, Yoshiko; Sena, Brena; Chudnovskiy, Aleksey; Panizzi, Peter; Higgins, John Matthew; Libby, Peter; Moskowitz, Michael Arthur; Pittet, Mikael J.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (The Rockefeller University Press, 2012)
      IL-1b signaling augments continued splenic monocyte supply during acute inflammation.
    • Remote control of macrophage production by cancer 

      Cortez-Retamozo, Virna; Engblom, Camilla; Pittet, Mikael J. (Landes Bioscience, 2013)
      The communication between tumor and host cells involves signals that act across extended distances in the body. Recent evidence indicates that the hormone angiotensin II is overproduced by lung adenocarcinoma to remotely ...
    • Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor 

      Azroyan, Anie; Cortez-Retamozo, Virna; Bouley, Richard; Liberman, Rachel; Ruan, Ye Chun; Kiselev, Evgeny; Jacobson, Kenneth A.; Pittet, Mikael J.; Brown, Dennis; Breton, Sylvie (Public Library of Science, 2015)
      Uncontrolled inflammation is one of the leading causes of kidney failure. Pro-inflammatory responses can occur in the absence of infection, a process called sterile inflammation. Here we show that the purinergic receptor ...
    • Tumor associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug 

      Miller, Miles A.; Zheng, Yao-Rong; Gadde, Suresh; Pfirschke, Christina; Zope, Harshal; Engblom, Camilla; Kohler, Rainer H.; Iwamoto, Yoshiko; Yang, Katherine S.; Askevold, Bjorn; Kolishetti, Nagesh; Pittet, Mikael; Lippard, Stephen J.; Farokhzad, Omid C.; Weissleder, Ralph (2015)
      Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral ...