Browsing by Author "Cheifetz, Adam"
Now showing items 1-9 of 9
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Attitudes to Mesalamine Questionnaire: A Novel Tool to Predict Mesalamine Nonadherence in Patients with IBD
Moss, Alan C; Lillis, Yvonne; Edwards George, Jessica B.; Choudhry, Niteesh Kumar; Berg, Anders Hayden; Cheifetz, Adam S.; Horowitz, Gary Leigh; Leffler, Daniel Alexander (Springer Nature, 2014)OBJECTIVES: Poor adherence to mesalamine is common and driven by a combination of lifestyle and behavioral factors, as well as health beliefs. We sought to develop a valid tool to identify barriers to patient adherence and ... -
Biologic Concentration Testing in Inflammatory Bowel Disease
Vaughn, Byron P.; Sandborn, William J.; Cheifetz, Adam S. (Lippincott Williams & Wilkins, 2015)Abstract: Anti-TNF medications have revolutionized the care of patients with inflammatory bowel disease. However, despite an initial robust effect, loss of response is common and long-term results are disappointing. Much ... -
CD39 and CD161 Modulate Th17 Responses in Crohn's Disease
Bai, Aiping; Moss, Alan; Kokkotou, Efi; Usheva, Anny; Sun, Xiaofeng; Cheifetz, Adam; Zheng, Yi; Longhi, Maria Serena; Gao, Wenda; Wu, Yan; Robson, Simon (The American Association of Immunologists, 2014-08-29)CD39 (ENTPD1) is expressed by subsets of pathogenic human CD4+ T cells, such as T helper type 17 (Th17) cells. These Th17 cells are considered important in intestinal inflammation, such as seen in Crohn’s disease. Recently, ... -
CD73 Is a Phenotypic Marker of Effector Memory Th17 Cells in Inflammatory Bowel Disease
Doherty, Glen; Bai, Aiping; Hanidziar, Dusan; Longhi, Maria Serena; Lawlor, Garrett; Putheti, Prabhakar; Csizmadia, Eva; Nowak, Martina; Cheifetz, Adam; Moss, Alan; Robson, Simon (Wiley, 2012-10-29)Purinergic signaling and associated ectonucleotidases, such as CD39 and CD73, have been implicated in the pathogenesis of inflammatory bowel disease (IBD). CD39 is known to be a Treg memory cell marker, and here we determine ... -
Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease
Longhi, Maria Serena; Moss, Alan; Bai, Aiping; Wu, Yan; Huang, Huang; Cheifetz, Adam; Quintana, Francisco J.; Robson, Simon C. (Public Library of Science, 2014)Induced regulatory T-cells (iT-reg) and T helper type 17 (Th17) in the mouse share common CD4 progenitor cells and exhibit overlapping phenotypic and functional features. Here, we show that human Th17 cells endowed with ... -
Lectin-Reactive Anti-α-Gal in Patients with Crohnʼs Disease: Correlation with Clinical Phenotypes
Safaie, Parham; Ham, Maggie; Kuang, Peter; Mehta, Anand S.; Wang, Mengjun; Cheifetz, Adam; Robson, Simon; Lau, Daryl; Block, Timothy M.; Moss, Alan C. (Oxford University Press (OUP), 2013-12-01)Background Patients with inflammatory bowel disease have higher proportions of immunoglobulin G (IgG) antibodies lacking N-galactose, also called agalactosyl IgG, in their serum. Such agalactosyl IgGs have been associated ... -
Systematic review and meta-analysis of third-line salvage therapy with infliximab or cyclosporine in severe ulcerative colitis
Feuerstein, Joseph D.; Akbari, Mona; Tapper, Elliot B.; Cheifetz, Adam S. (Hellenic Society of Gastroenterology, 2016)Background: In patients with ulcerative colitis who fail corticosteroids and are treated with rescue therapy (e.g. infliximab or cyclosporine) but fail to respond, salvage therapy with infliximab or cyclosporine can be ... -
The Use of Pharmacological Prophylaxis Against Venous Thromboembolism in Hospitalised Patients With Severe Active Ulcerative Colitis
Pleet, J. L.; Vaughn, Byron P.; Morris, J. A.; Moss, Alan C.; Cheifetz, Adam (Wiley, 2014-05)Background Hospitalised patients with inflammatory bowel disease are 1.5- to 3.5-fold more likely to develop venous thromboembolism compared to controls. Clinical guidelines recommend pharmacological prophylaxis. Aim To ... -
Vitamin D Levels in Adults with Crohnʼs Disease Are Responsive to Disease Activity and Treatment
Brigham, Maggie; Longhi, Maria Serena; Lahiff, Conor; Cheifetz, Adam; Robson, Simon; Moss, Alan C. (Oxford University Press (OUP), 2014-05)Background: Vitamin D deficiency is common in patients with Crohn’s disease (CD), although whether this impairs immune responsiveness, and is related to disease activity per se, remains unclear. We sought to investigate ...