Now showing items 1-8 of 8

    • Canonical and Atypical E2Fs Regulate the Mammalian Endocycle 

      Chen, Hui-Zi; Ouseph, Madhu M.; Li, Jing; Pécot, Thierry; Chokshi, Veda; Kent, Lindsey; Bae, Sooin; Byrne, Morgan; Duran, Camille; Comstock, Grant; Trikha, Prashant; Mair, Markus; Senapati, Shantibhusan; Martin, Chelsea K.; Gandhi, Sagar; Wilson, Nicholas; Liu, Bin; Huang, Yi-Wen; Thompson, John C.; Raman, Sundaresan; Singh, Shantanu; Leone, Marcelo; Machiraju, Raghu; Huang, Kun; Mo, Xiaokui; Fernandez, Soledad; Kalaszczynska, Ilona; Wolgemuth, Debra J.; Sicinski, Piotr; Huang, Tim; Jin, Victor; Leone, Gustavo (2012)
      SUMMARY The endocycle is a variant cell cycle consisting of successive DNA synthesis and Gap phases that yield highly polyploid cells. Although essential for metazoan development, relatively little is known about its control ...
    • Cyclin A2 promotes DNA repair in the brain during both development and aging 

      Gygli, Patrick E.; Chang, Joshua C.; Gokozan, Hamza N.; Catacutan, Fay P.; Schmidt, Theresa A.; Kaya, Behiye; Goksel, Mustafa; Baig, Faisal S.; Chen, Shannon; Griveau, Amelie; Michowski, Wojciech; Wong, Michael; Palanichamy, Kamalakannan; Sicinski, Piotr; Nelson, Randy J.; Czeisler, Catherine; Otero, José J. (Impact Journals LLC, 2016)
      Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development yet achieves ...
    • Cyclin D activates the Rb tumor suppressor by mono-phosphorylation 

      Narasimha, Anil M; Kaulich, Manuel; Shapiro, Gary S; Choi, Yoon J; Sicinski, Piotr; Dowdy, Steven F (eLife Sciences Publications, Ltd, 2014)
      The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release ...
    • Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells 

      Das, Gaurav; Choi, Yoon; Sicinski, Piotr; Levine, Edward M (BioMed Central, 2009)
      Background: Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina. The cell cycle regulator cyclin D1 is expressed in ...
    • Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α 

      Bhalla, Kavita; Liu, Wan-Ju; Thompson, Keyata; Anders, Lars; Devarakonda, Srikripa; Dewi, Ruby; Buckley, Stephanie; Hwang, Bor-Jang; Polster, Brian; Dorsey, Susan G.; Sun, Yezhou; Sicinski, Piotr; Girnun, Geoffrey D. (American Diabetes Association, 2014)
      Hepatic gluconeogenesis is crucial to maintain normal blood glucose during periods of nutrient deprivation. Gluconeogenesis is controlled at multiple levels by a variety of signal transduction and transcriptional pathways. ...
    • Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression 

      Lee, Yoonjin; Dominy, John E.; Choi, Yoon Jong; Jurczak, Michael; Tolliday, Nicola; Camporez, Joao Paulo; Chim, Helen; Lim, Ji-Hong; Ruan, Hai-Bin; Yang, Xiaoyong; Vazquez, Francisca; Sicinski, Piotr; Shulman, Gerald I.; Puigserver, Pere (2014)
      Insulin constitutes a major evolutionarily conserved hormonal axis for maintaining glucose homeostasis1-3; dysregulation of this axis causes diabetes2,4. PGC-1α links insulin signaling to the expression of glucose and lipid ...
    • p600 Plays Essential Roles in Fetal Development 

      Nakaya, Takeo; Ishiguro, Kei-ichiro; Belzil, Camille; Rietsch, Anna M.; Yu, Qunyan; Mizuno, Shin-ichi; Bronson, Roderick T.; Geng, Yan; Nguyen, Minh Dang; Akashi, Koichi; Sicinski, Piotr; Nakatani, Yoshihiro (Public Library of Science, 2013)
      p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While ...
    • Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo 

      Odajima, Junko; Saini, Siddharth; Jung, Piotr; Ndassa-Colday, Yasmine; Ficaro, Scott; Geng, Yan; Marco, Eugenio; Michowski, Wojciech; Wang, Yaoyu E.; DeCaprio, James A.; Litovchick, Larisa; Marto, Jarrod; Sicinski, Piotr (Public Library of Science, 2016)
      E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division. It is unknown whether in addition ...