Browsing by Author "Shen, Jun"
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Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
Shu, Yilai; Tao, Yong; Li, Wenyan; Shen, Jun; Wang, Zhengmin; Chen, Zheng-Yi (Hindawi Publishing Corporation, 2016)Mammalian inner ear harbors diverse cell types that are essential for hearing and balance. Adenovirus is one of the major vectors to deliver genes into the inner ear for functional studies and hair cell regeneration. To ... -
C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells
Kwan, Kelvin Y.; Shen, Jun; Corey, David P. (Elsevier, 2015)Summary Sensorineural hearing loss is caused by the loss of sensory hair cells and neurons of the inner ear. Once lost, these cell types are not replaced. Two genes expressed in the developing inner ear are c-Myc and Sox2. ... -
Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction
Wang, Tao; Xu, Chenchen; Zhou, Xiping; Li, Chunjia; Zhang, Hongbing; Lian, Bill Q.; Lee, Jonathan J.; Shen, Jun; Liu, Yuehua; Lian, Christine Guo (MDPI, 2015)Non-bullous congenital ichthyosiform erythroderma (NBCIE) is a hereditary disorder of keratinization caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte ... -
SHIELD: an integrative gene expression database for inner ear research
Shen, Jun; Scheffer, Déborah I.; Kwan, Kelvin Y.; Corey, David P. (Oxford University Press, 2015)The inner ear is a highly specialized mechanosensitive organ responsible for hearing and balance. Its small size and difficulty in harvesting sufficient tissue has hindered the progress of molecular studies. The protein ...