Browsing by Author "Ohguchi, Hiroto"

Now showing items 1-4 of 4

    • Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma 

      Kikuchi, Shohei; Suzuki, Rikio; Ohguchi, Hiroto; Yoshida, Yashiro; Lu, Duo; Cottini, Francesca; Jakubikova, Jana; Bianchi, Giada; Harada, Takeshi; Gorgun, Guliu; Tai, Yu-Tzu; Richardson, Paul Gerard Guy; Hideshima, Teru; Anderson, Kenneth Carl (Springer Science and Business Media LLC, 2015-03-24)
      Histone deacetylase (HDAC) inhibitors have been extensively investigated as therapeutic agents in cancer. However, the biologic role of class IIa HDACs (HDAC4, 5, 7 and 9) in cancer cells, including multiple myeloma (MM), ...

    • Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells 

      Suzuki, Rikio; Kikuchi, Shohei; Harada, Takeshi; Mimura, Naoya; Minami, Jiro; Ohguchi, Hiroto; Yoshida, Yasuhiro; Sagawa, Morihiko; Gorgun, Gullu; Cirstea, Diana; Cottini, Francesca; Jakubikova, Jana; Tai, Yu-Tzu; Chauhan, Dharminder; Richardson, Paul G.; Munshi, Nikhil; Ando, Kiyoshi; Utsugi, Teruhiro; Hideshima, Teru; Anderson, Kenneth C. (Public Library of Science, 2015)
      Heat shock protein (HSP)90 inhibitors have shown significant anti-tumor activities in preclinical settings in both solid and hematological tumors. We previously reported that the novel, orally available HSP90α/β inhibitor ...

    • HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications 

      Harada, Takeshi; Ohguchi, Hiroto; Grondin, Yohann Renald; Kikuchi, Shannon Adele; Sagawa, Morihiko; Tai, Y-T; Mazitschek, Ralph; Hideshima, Teru; Anderson, Kenneth Carl (Springer Science and Business Media LLC, 2017-05-11)
      Epigenetic signaling pathways are implicated in tumorigenesis and therefore histone deacetylases (HDACs) represent novel therapeutic targets for cancers, including multiple myeloma (MM). Although non-selective HDAC inhibitors ...

    • KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival 

      Ohguchi, Hiroto; Harada, Takeshi; Sagawa, Morihiko; Kikuchi, Shannon Adele; Tai, Yu-Tzu; Richardson, Paul Gerard Guy; Hideshima, Teru; Anderson, Kenneth Carl (Springer Nature, 2017)
      Recent studies have delineated cancer type-specific roles of histone 3 lysine 27 (H3K27) demethylase KDM6B/JMJD3 depending on its H3K27 demethylase activity. Here we show that KDM6B is expressed in multiple myeloma (MM); ...