Browsing by Author "Brummel, Sean"

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Genetically determined ancestry is more informative than self-reported race in HIV-infected and -exposed children

Spector, Stephen A.; Brummel, Sean S.; Nievergelt, Caroline M.; Maihofer, Adam X.; Singh, Kumud K.; Purswani, Murli U.; Williams, Paige L.; Hazra, Rohan; Van Dyke, Russell; Seage, George R. (Wolters Kluwer Health, 2016)

Abstract The Pediatric HIV/AIDS Cohort Study (PHACS), the largest ongoing longitudinal study of perinatal HIV-infected (PHIV) and HIV-exposed, uninfected (PHEU) children in the United States, comprises the Surveillance ...
Killer Cell Immunoglobulin-Like Receptor Alleles Alter HIV Disease in Children

Singh, Kumud K.; Qin, Min; Brummel, Sean S.; Angelidou, Konstantia; Trout, Rodney N.; Fenton, Terence; Spector, Stephen A. (Public Library of Science, 2016)

Background: HLA class I molecules are ligands for killer cell immunoglobin like receptors (KIR) that control the antiviral response of natural killer (NK) cells. However, the effects of KIR and HLA (KIR/HLA) alleles on HIV ...
On the Use of Local Assessments for Monitoring Centrally Reviewed Endpoints with Missing Data in Clinical Trials*

Brummel, Sean S.; Gillen, Daniel L. (2013)

Due to ethical and logistical concerns it is common for data monitoring committees to periodically monitor accruing clinical trial data to assess the safety, and possibly efficacy, of a new experimental treatment. When ...