Now showing items 1-3 of 3

    • Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy 

      Kuijjer, Marieke L; van den Akker, Brendy EWM; Hilhorst, Riet; Mommersteeg, Monique; Buddingh, Emilie P; Serra, Massimo; Bürger, Horst; Hogendoorn, Pancras CW; Cleton-Jansen, Anne-Marie (BioMed Central, 2014)
      Background: High-grade osteosarcoma is a primary malignant bone tumor mostly occurring in adolescents and young adults, with a second peak at middle age. Overall survival is approximately 60%, and has not significantly ...
    • MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation 

      Baranski, Zuzanna; Booij, Tijmen H.; Kuijjer, Marieke L.; de Jong, Yvonne; Cleton-Jansen, Anne-Marie; Price, Leo S.; van de Water, Bob; Bovée, Judith V. M. G.; Hogendoorn, Pancras C.W.; Danen, Erik H.J. (Impact Journals LLC, 2015)
      Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people. Recurrent and metastatic tumors are difficult to treat. We performed a kinase inhibitor screen in ...
    • PyPanda: a Python package for gene regulatory network reconstruction 

      van IJzendoorn, David G.P.; Glass, Kimberly; Quackenbush, John; Kuijjer, Marieke L. (Oxford University Press, 2016)
      Summary: PANDA (Passing Attributes between Networks for Data Assimilation) is a gene regulatory network inference method that uses message-passing to integrate multiple sources of ‘omics data. PANDA was originally coded ...